CILIARY MUSCLE AGING AND PRESBYOPIA

睫状肌老化和老花眼

• 批准号: 8173059
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173059
• 关键词: Affect; Age; Aging; Biological; Caliber; Ciliary Body; Ciliary Muscle; Computer Retrieval of Information on Scientific Projects Database; Eye; Funding; Grant; Human; Institution; Macaca mulatta; Modeling; Monkeys; Morphology; Movement; Muscle; Presbyopia; Printing; Relative (related person); Research; Research Personnel; Resources; Services; Shapes; Source; Structure; United States National Institutes of Health; Width; age related; design; insight; lens; muscle aging; nonhuman primate; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand human presbyopia by studying the dynamics of accommodation and presbyopia in nonhuman primates. Nonhuman primates are the preferred model for human presbyopia, the age-related loss of the ability to focus. Focus depends on the ability of the lens to change shape (i.e. lens thickening and a concomitant decrease in lens equatorial diameter). Lens shape change depends upon forward and inward movement of the ciliary muscle. Previously, we found an age-related in loss in ciliary muscle movement that was more pronounced in the forward rather than the centripetal vector. Current findings show that accommodative lens thickening declined with age more markedly than accommodative lens diameter. This could be due to simple geometric / biophysical necessity and/or aging changes inherent in lens structure. Age-related changes in accommodative lens thickening may not be the same quantitatively or mechanistically as the age-related changes in accommodative diameter, regardless of the ciliary body state of contraction. The ciliary muscle's ability to maintain some centripetal movement while undergoing a dramatic loss in forward movement with increasing age may also have an impact on differential lens shape changes (i.e., accommodative thickening vs. equatorial movements). Whether the age-related differences in lens thickening vs. lens equator movements are due to the lens itself or to changes in ciliary body movements, these findings may provide insights into successful accommodating IOL design. The presence of the vitreous zonule was confirmed in the human eye. Disruption of the vitreous zonule restored forward muscle movement in the older rhesus monkey eye. This raises the possibility that the vitreous zonule could be a biological target, the disruption of which could be used to restore forward muscle movement. Further, there was an age-related decrease in width of the ciliary body in the vitreous zonule/pars plana region and this may have an effect on the vitreous zonule tension and may affect lens shape and thereby accommodation. Again, these findings may provide some insight into successful accommodating IOL design. This research used WNPRC Research Services. PUBLICATIONS: Croft MA, McDonald JP, Nadkarni NV, Lin TL, Kaufman PL: Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. Exp Eye Res 89:824-832, 2009 (Dec) PMCID278077 L¿tjen-Drecoll E, Kaufman PL, Wasielewski R, Lin TL, Croft MA: Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Invest Ophthalmol Vis Sci, Epub ahead of print, Oct 8, 2009.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。主题项目和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 目的：通过研究非人类隐私的住宿和长老会的动态来了解人类长老会。 非人类隐私是人类长老会的首选模型，这是与年龄相关的集中能力的丧失。重点取决于镜头改变形状的能力（即晶状体增厚和晶状体等效直径的降低）。晶状体形状的变化取决于睫状肌的前进和向内运动。以前，我们发现睫状肌运动中与年龄相关的损失相关，在正向而不是中心载体中更为明显。当前的发现表明，容纳晶状体增厚的年龄比容纳透镜直径更明显。这可能是由于透镜结构固有的简单几何 /生物物理和 /或衰老变化所致。与年龄相关的晶状体厚度的变化在定量或机械上可能不会与与年龄相关的容量直径变化相同，而不论纤毛体的收缩状态如何。睫状肌能够保持某些中心运动的能力，同时又会随着年龄的增长而经历急剧移动的急剧损失，也可能对差异镜头形状变化产生影响（即适应性增厚与等效性运动）。无论与年龄相关的镜头增厚与镜头等效运动的差异是否是由于镜头本身或睫状体运动的变化所致，这些发现都可以提供对成功适应IOL设计的见解。 在人眼中证实了玻璃体扎元的存在。玻璃体扎子的破坏恢复了旧恒河猴眼前的肌肉运动。这增加了玻璃体扎元可能是生物学靶标的可能性，其破坏可用于恢复前向肌肉运动。此外，在玻璃体卵形/pars平面区域中睫状体的宽度与年龄有关，这可能会影响玻璃体扎块张力，并可能影响透镜的形状并因此会影响镜片。同样，这些发现可能会提供有关成功住宿IOL设计的一些见解。 这项研究使用了WNPRC研究服务。 出版物： Croft MA，McDonald JP，Nadkarni NV，Lin TL，Kaufman PL：相对于猴子的中心透镜运动，与年龄相关的夹层纤毛体运动的变化。 Exp Eye Res 89：824-832，2009（DEC）PMCID278077 L tjen-Drecoll E，Kaufman PL，Wasielewski R，Lin TL，Croft MA：人和猴子眼中玻璃体分子的形态和可接受性功能。 2009年10月8日，Invest Ophthalmol Vis Sci，Epub发行。