LENS LASER STRATEGIES FOR PRESBYOPIA

老花眼的晶状体激光治疗策略

• 批准号: 8173100
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173100
• 关键词: Animals; Behavior; Burn injury; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Electrodes; Exhibits; Eye; Funding; Grant; Hour; Housing; Implant; Institution; Lasers; Macaca mulatta; Measurement; Monkeys; Pain; Presbyopia; Procedures; Research; Research Personnel; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; lens; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering and the animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Reevaluation of the project will be conducted in the upcoming year to determine a suitable end-point. This research used WNPRC Research Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定老年恒河猴在晶状体激光治疗前后接受中枢刺激后的调节能力。 目前，接受晶状体激光治疗的猴子正在被安置进行长期观察。 此前，研究人员将电极植入两只老年恒河猴的每只埃丁格韦斯特法尔核中，以便集中刺激调节。此外，4只幼小的恒河猴被用作测试对象来校准飞秒激光。 在确定晶状体激光对调节反应的影响之前完成基线测试。飞秒激光手术似乎在猴眼中具有良好的耐受性。然而，在接受激光照射的 5 只猴子中，有 2 只出现了轻微的视网膜烧伤（大小为 1-2 毫米）。激光照射后 24 小时开始的飞秒激光程序并未影响使用 Hartinger 符合折射仪获得屈光测量的能力，并且动物没有表现出异常行为或疼痛或不适的迹象。 其余四只恒河猴每年两次进行裂隙灯检查。所有动物都保持正常视力。明年将对该项目进行重新评估，以确定合适的终点。 本研究使用了 WNPRC 研究服务。