LENS LASER STRATEGIES FOR PRESBYOPIA

老花眼的晶状体激光治疗策略

• 批准号: 8173100
• 负责人: PAUL L KAUFMAN
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173100
• 关键词: Animals; Behavior; Burn injury; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Electrodes; Exhibits; Eye; Funding; Grant; Hour; Housing; Implant; Institution; Lasers; Macaca mulatta; Measurement; Monkeys; Pain; Presbyopia; Procedures; Research; Research Personnel; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; lens; response; Animals; Behavior; Burn injury; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Electrodes; Exhibits; Eye; Funding; Grant; Hour; Housing; Implant; Institution; Lasers; Macaca mulatta; Measurement; Monkeys; Pain; Presbyopia; Procedures; Research; Research Personnel; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; lens; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering and the animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Reevaluation of the project will be conducted in the upcoming year to determine a suitable end-point. This research used WNPRC Research Services.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：确定晶状体激光前后的中央刺激后，较老的恒河猴的适应能力。 目前，接受了对镜头的激光治疗的猴子正在容纳长期观察。 以前，将电极植入了两个较老的恒河猴中的每个核心的Edinger Westphal核中，以便可以将其集中刺激。另外，将4只年轻的恒河猴用作测试对象，以校准飞秒激光。 在确定晶状体激光对适应性响应的影响之前完成了基线测试。飞秒激光程序似乎在猴子眼中耐受性良好。然而，在5个猴子中的2个猴子中，有2只视网膜燃烧（1-2毫米）。从激光后24小时开始，并没有表现出异常的行为或疼痛或不适的证据，从而通过飞秒激光手术从Hartinger巧合折光仪获得折射率的能力并没有损害。 在其余四个恒河猴中双年度进行缝隙灯检查。所有动物都保持正常视力。该项目的重新评估将在下一年进行，以确定合适的终点。 这项研究使用了WNPRC研究服务。