Detecting the disruption and recovery of synaptic connectivity after TBI

检测 TBI 后突触连接的破坏和恢复

基本信息

批准号：
10092458
负责人：
MARK P BURNS
金额：
$ 38.71万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-15 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10092458
关键词：
Acute Adult Aging Animal Model Animals Architecture Area Award Behavior Behavioral Biochemistry Biology Brain Contusions Burn injury Chronic Clinical Data Analyses Data Collection District of Columbia Electrophysiology (science)Ensure Event Functional Magnetic Resonance Imaging Functional disorder Goals Guidelines HIV Seropositivity Heterogeneity Hippocampus (Brain)IACUC Image Impaired cognition Impairment Individual Differences Inflammation Injury Intervention Learning Long-Term Potentiation Magnetic Resonance Imaging Measures Memory Methods Modeling Molecular Biology Morphology Mus Neuronal Dysfunction Neurons Outcome Patients Pattern Phase Procedures Protocols documentation Recovery Regression Analysis Reporting Research Research Design Research Personnel Severities Statistical Data Interpretation Synapses Techniques Technology TimeLine Traumatic Brain Injury Traumatic Brain Injury recovery Validation Work animal tissue axon injury base behavioral outcome blind cognitive ability cognitive function controlled cortical impact data sharing fluid percussion injury functional MRI scan head impact improved mild traumatic brain injury multidisciplinary neural network neurobehavior neuroinflammation neuron loss neuronal circuitry novel outcome prediction preference receptor response synaptic function tau aggregation tau-1

项目摘要

PROJECT SUMMARY The rationale for this proposal is that synaptic integrity is essential for neuronal function. Disruptions to synaptic integrity are downstream of common TBI pathophysiological events including neuronal cell death, axonal injury, p-tau aggregation, and neuroinflammation. The ability to detect discrete changes in synaptic integrity – regardless of the upstream mechanism of synapse loss – will allow clinicians to track the ability of clinical interventions to improve chronic outcome in patients. The objective of this proposal is to use measures of synaptic integrity to predict chronic behavioral outcomes, and to validate Hcorr as a non-invasive marker of synaptic integrity for use in TBI.

项目摘要该建议的理由是突触完整性对于神经元功能至关重要。干扰突触完整性是常见TBI病理生理事件的下游，包括神经元细胞死亡，轴突损伤，P-TAU聚集和神经炎症。检测突触的离散变化的能力诚信 - 无论突触损失的上游机制如何 - 都将使临床医生能够跟踪临床干预措施以改善患者的慢性预后。该提议的目的是使用措施突触完整性以预测慢性行为结果，并验证HCORR作为非侵入性标记用于TBI的突触完整性。