Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement

体力活动和减肥可改善全膝关节置换术后的功能和疼痛

• 批准号: 10711058
• 负责人: Christine Ann Pellegrini
• 金额: $ 27.95万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711058
• 关键词: Acute; Adult; Aerobic; Alzheimer' s Disease; Behavior; Behavioral; Body Weight decreased; Cardiovascular Diseases; Cessation of life; Chronic Disease; Cognition; Control Groups; Crossover Design; Dementia; Development; Diet; Dietary intake; Economic Burden; Excess Mortality; Health Care Costs; Individual; Life Style; Measures; Operative Surgical Procedures; Outcome; Pain; Parents; Participant; Physical Function; Physical activity; Randomized; Rest; Self Management; Societies; Testing; Walking; Weight; aging population; cognitive testing; functional improvement; high risk population; knee replacement arthroplasty; mortality; prevent; processing speed; programs; protective effect; self-management program; weight loss program

Project Summary/Abstract The Parent R01 is examining the effects of a behavioral weight loss program as compared to a chronic disease self-management (CDSM) program on weight, physical function, pain, and physical activity among adults after total knee replacement (TKR). The proposed supplemental project aims to add an Alzheimer’s disease and its related dementias (AD/ADRD) focus to our project by examining whether a behavioral weight loss program and physical activity may have a protective effect against AD/ADRD among adults with TKR by sustaining cognition. An increasing number of individuals are undergoing TKR, and although the surgery helps to initially reduce mortality, the majority of deaths in the decades after surgery are from AD/ADRD and cardiovascular disease. Healthcare costs from AD/ADRD are among the highest in the US, placing substantial economic burden on society. Although the reasons for the excess mortality from AD/ADRD among adults with TKR are unknown, strategies are needed to help reduce this population’s high risk for the development of AD/ADRD as well as the corresponding economic burden that this surgery and conditions place on society. The first Aim of the supplement is to examine the preliminary effects of a multicomponent (diet and physical activity) weight loss program as compared to a CDSM control group on cognition at 6 months. The second Aim will examine how changes in diet, aerobic physical activity, and weight are associated with cognition at 6 months. The final Aim is to examine the acute effects of a brief bout of walking on cognition. To examine aims 1 and 2, participants (n=60) will be randomized to one of two 12-month programs: (1) PACE weight loss program or (2) CDSM. Assessments at baseline and 6 months will include measures of cognition, weight, objectively-measured physical activity, and dietary intake. To examine aim 3, a cross-over design will be used at the baseline assessment, in which participants (n=60) will be randomized to either Immediate or Delayed walking conditions. Participants randomized to Immediate will complete the Six-min walking test first, whereas participants randomized to delayed will complete the walking test after a 6-min rest period. A brief cognitive test assessing processing speed will be completed 3 times at the baseline assessment to examine the effect of an acute walking bout on cognition. The expected outcome from this supplemental project is to determine the preliminary effects of changes in weight, aerobic physical activity, and dietary intake on cognition in adults after TKR. If a behavioral weight loss program and/or briefs bouts of activity can sustain cognition among an aging population, the promotion of changes in these lifestyle behaviors could help to prevent or delay the onset of AD/ADRD.

项目摘要/摘要 与慢性相比，父R01正在检查行为减肥计划的影响 疾病自我管理（CDSM）计划有关体重，身体机能，疼痛和体育锻炼的计划 全膝盖置换后的成人（TKR）。拟议的补充项目旨在增加阿尔茨海默氏症 疾病及其相关痴呆症（AD/ADRD）通过检查行为重量是否将重点放在我们的项目上 损失计划和体育锻炼可能对TKR成年人的AD/ADRD具有保护作用 维持认知。越来越多的个体正在接受TKR，尽管手术有助于 最初降低死亡率，手术后几十年中的大多数死亡来自AD/ADRD， 心血管疾病。 AD/ADRD的医疗保健费用是美国最高的 经济焚烧社会。虽然成年人的AD/ADRD过多死亡的原因 TKR是未知的，需要采取策略来帮助减少该人群的高风险发展 AD/ADRD以及该手术和条件在社会上的相应经济燃烧。 该补充剂的第一个目的是检查多组分的初步效果（饮食和物理 与CDM对照组相比，体重减轻计划在6个月时认知。第二个目标 将检查饮食，有氧运动和体重的变化与6点的认知有关 月份。最终目的是检查步行对认知的短暂出现的急性影响。检查目标 1和2，参与者（n = 60）将被随机分为两个12个月的程序之一：（1）减肥 程序或（2）CDSM。基线和6个月的评估将包括认知，体重， 客观测量的体育锻炼和饮食摄入量。要检查AIM 3，将使用跨界设计 在基线评估中，参与者（n = 60）将随机分配给立即或延迟 步行条件。参与者立即随机完成六分钟步行测试，而 参与者在6分钟的休息期间随机延迟将完成步行测试。简短的认知 测试评估处理速度将在基线评估中完成3次，以检查 认知方面的急性步行。 这个补充项目的预期结果是确定 TKR后，体重的变化，有氧体育锻炼和成人认知的饮食摄入量的变化。如果行为 减肥计划和/或活动摘要可以维持老龄化的人口认知， 促进这些生活方式行为的变化可以帮助预防或延迟广告/ADRD的发作。

项目成果

A pooled analysis of the association between sarcopenia and osteoporosis.

• DOI: 10.1097/md.0000000000031692
• 发表时间: 2022-11-18
• 期刊: MEDICINE
• 影响因子: 1.6
• 作者: Yu, Xiaochao;Sun, Shuo;Zhang, Shaoxiong;Hao, Qinggang;Zhu, Boheng;Teng, Yirong;Long, Qing;Li, Shujun;Lv, Yan;Yue, Qiaoning;Lu, Sheng;Teng, Zhaowei
• 通讯作者: Teng, Zhaowei