LENS LASER STRATEGIES FOR PRESBYOPIA

老花眼的晶状体激光治疗策略

• 批准号: 8358210
• 负责人: PAUL L KAUFMAN
• 金额: $ 0.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358210
• 关键词: Animals; Behavior; Burn injury; Cell Nucleus; Electrodes; Exhibits; Eye; Funding; Future; Grant; Hour; Housing; Implant; Lasers; Macaca mulatta; Measurement; Monitor; Monkeys; National Center for Research Resources; Pain; Pathology; Presbyopia; Primates; Principal Investigator; Procedures; Research; Research Infrastructure; Resources; Retinal; Services; Source; Testing; United States National Institutes of Health; Vision; Wisconsin; cost; lens; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. RESULTS: Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger- Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition, 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering. Animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Presently the animals continue to be monitored and future experimental plans are being considered. This research used WNPRC Animal and Pathology Services.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目的：确定老年恒河猴在晶状体激光治疗前后接受中枢刺激后的调节能力。 结果： 目前，接受晶状体激光治疗的猴子正在被安置进行长期观察。 此前，我们将电极植入两只老年恒河猴的每只埃丁格-威斯特法尔核中，以便集中刺激调节。此外，还用4只幼年恒河猴作为测试对象来校准飞秒激光。 在确定晶状体激光对调节反应的影响之前完成基线测试。飞秒激光手术似乎在猴眼中具有良好的耐受性。然而，在接受激光照射的 5 只猴子中，有 2 只出现了轻微的视网膜烧伤（大小为 1-2 毫米）。使用 Hartinger 符合折射仪获得折射测量的能力并未因激光照射后 24 小时开始的飞秒激光程序而受到影响。动物没有表现出异常行为或疼痛或不适的证据。 其余四只恒河猴每年两次进行裂隙灯检查。所有动物都保持正常视力。目前，这些动物仍在接受监测，并正在考虑未来的实验计划。 这项研究使用了 WNPRC 动物和病理学服务。