High-risk HPV infections in 18- 24-year-old women who date on-line

18-24岁网上约会女性的高危HPV感染

• 批准号: 8137156
• 负责人: RACHEL L. WINER
• 金额: $ 7.32万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-03 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8137156
• 关键词: Accounting; Address; Adolescent; Age; Attitude; Biological Assay; Cervical; Characteristics; Contraceptive Usage; DNA; Diagnostic; Enrollment; HPV-High Risk; Health; Health behavior; Heterosexuals; Hormonal; Human Papillomavirus; Human papilloma virus infection; Incidence; Internet; Literature; Longitudinal Studies; Mails; Participant; Population; Premalignant; Prevalence; Prevention strategy; Protocols documentation; Public Health; Questionnaires; Recruitment Activity; Reporting; Research Personnel; Risk; Risk Factors; Sampling; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Smoking; Specimen; Testing; United States; Vaccination; Vagina; Woman; aged; base; cohort; experience; high risk; human old age (65+); interest; meetings; older women; prophylactic; public health relevance; social networking website; web site

DESCRIPTION (provided by investigator): HPV prevalence is highest among women in their early twenties and decreases with age. While many risk factors for HPV infections in adolescent and young women are well-defined (including reports of new sex partners), it is unclear whether seeking sex partners via Internet dating or social networking websites is associated with increased risk of HPV infection. In our ongoing longitudinal study of high-risk (HR HPV) infections in 25-65 year old women who date online, having met recent partners online (versus via other means) was associated with an increased risk of HR HPV infection, but studies of younger heterosexual women have been equivocal. Understanding population-specific risk factors for HPV infection are critical to developing accurate public health messages and HPV prevention strategies. To examine risk factors for HR HPV infections in 18-24 year old online daters, we propose a longitudinal study of 200 women in the United States who have used online dating websites in the past year. Women will be recruited through the Internet. For one year, women will be asked to mail in four sets of self-collected vaginal specimens for HPV DNA testing (at 0, 4, 8, and 12 months), and to complete questionnaires on their health and sexual behavior (at 0, 4, 8, and 12 months) and attitudes towards self-collecting vaginal samples (at the end of study participation). Vaginal samples will be tested for type-specific HPV DNA using a PCR-based assay. The study protocol will be identical to our ongoing study of HR HPV infections in 25-65 year old women, and will thus also allow us to directly compare prevalence and incidence of HR HPV infections in 25-65 year old women (whose rates of HPV infection are higher than those reported in the literature) to 18-24 year old women. The specific aims of are to 1) identify risk factors for HR HPV infections in 18-24 year old women who date online; 2) compare the prevalence and incidence of HR HPV in 18-24 year old women to the prevalence and incidence of HR HPV in older (25-44 year old and 45-65 year old) women previously recruited and followed with an identical protocol; and 3) evaluate study participants' experiences with self-collecting vaginal samples and general interest in diagnostic kits for self-collecting vaginal samples for HPV and other STI testing. PUBLIC HEALTH RELEVANCE: Relevance: Findings from this study of HR HPV in 18-24 year old women who date online will inform population-specific public health messages and HPV prevention strategies.

描述（由研究者提供）：HPV 患病率在二十岁出头的女性中最高，并随着年龄的增长而下降。虽然青少年和年轻女性感染 HPV 的许多危险因素已经明确（包括新性伴侣的报告），但尚不清楚通过互联网约会或社交网站寻找性伴侣是否与 HPV 感染风险增加相关。在我们正在进行的对 25-65 岁网上约会女性高危 (HR HPV) 感染的纵向研究中，在网上认识最近的伴侣（相对于通过其他方式）与 HR HPV 感染风险增加相关，但研究年轻的异性恋女性的态度模棱两可。了解特定人群的 HPV 感染风险因素对于制定准确的公共卫生信息和 HPV 预防策略至关重要。为了检查 18-24 岁在线约会者 HR HPV 感染的危险因素，我们建议对过去一年使用过在线约会网站的 200 名美国女性进行一项纵向研究。女性将通过互联网招募。在一年内，女性将被要求邮寄四套自行采集的阴道标本进行 HPV DNA 检测（0、4、8 和 12 个月时），并填写有关其健康和性行为的调查问卷（0、4、8 和 12 个月时）。 4、8 和 12 个月）以及对自行采集阴道样本的态度（在研究参与结束时）。将使用基于 PCR 的检测方法对阴道样本进行特定型 HPV DNA 检测。该研究方案将与我们正在进行的 25-65 岁女性 HR HPV 感染研究相同，因此也使我们能够直接比较 25-65 岁女性 HR HPV 感染的患病率和发病率（其 HPV 感染率） 18-24岁女性的感染率高于文献报道）。具体目标是 1) 确定 18-24 岁网上约会女性 HR HPV 感染的危险因素； 2) 将 18-24 岁女性中 HR HPV 的患病率和发病率与之前招募并遵循相同方案的老年女性（25-44 岁和 45-65 岁）中 HR HPV 的患病率和发病率进行比较； 3) 评估研究参与者对自行采集阴道样本的体验以及对用于 HPV 和其他 STI 检测的自行采集阴道样本的诊断试剂盒的普遍兴趣。 公共卫生相关性： 相关性：这项针对 18-24 岁在线约会女性的 HR HPV 研究结果将为特定人群的公共卫生信息和 HPV 预防策略提供信息。

项目成果

Incidence and risk factors for human papillomavirus infections in young female online daters.

年轻女性在线约会者人乳头瘤病毒感染的发病率和危险因素。

• DOI: 10.1002/jmv.24891
• 发表时间: 2017
• 期刊: Journal of medical virology
• 影响因子: 12.7
• 作者: Ma,Sharon;Stern,JoshuaE;Feng,Qinghua;Hughes,JamesP;Hawes,StephenE;Winer,RachelL
• 通讯作者: Winer,RachelL

Oncogenic Human Papillomavirus Infections in 18- to 24-Year-Old Female Online Daters.

18 至 24 岁女性在线约会者的致癌人乳头瘤病毒感染。

• DOI: 10.1097/olq.0000000000000331
• 发表时间: 2015
• 期刊: Sexually transmitted diseases
• 影响因子: 3.1
• 作者: Barrere,Alexis;Stern,JoshuaE;Feng,Qinghua;Hughes,JamesP;Winer,RachelL
• 通讯作者: Winer,RachelL