Epidemiology of oral gamma and beta HPV infections in mid-adult women

中成年女性口腔 γ 和 β HPV 感染的流行病学

• 批准号: 8636249
• 负责人: RACHEL L. WINER
• 金额: $ 7.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636249
• 关键词: Address; Adult; Age; Alcohol consumption; Anogenital cancer; Biological Assay; Biology; Consensus; DNA; Data; Dental Epidemiology; Development; Epidemiology; Genital system; HIV Seropositivity; Hand; Head and Neck Cancer; Health behavior; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunosuppression; Individual; Infection; Knowledge; Link; Malignant neoplasm of cervix uteri; Methods; Mouth Neoplasms; Natural History; Oncogenic; Oral; Oral Sex; Oral cavity; Oropharyngeal; Oropharyngeal Squamous Cell Carcinoma; Parents; Prevalence; Prevention strategy; Research; Role; Route; Sampling; Sex Behavior; Sexual Partners; Skin Cancer; Smoking; Structure of nail of finger; Tropism; Vagina; Viral Load result; Woman; aged; cigarette smoking; malignant mouth neoplasm; malignant oropharynx neoplasm; men; novel; oral HPV; oral carcinogenesis; oral tumorigenesis; public health relevance; transmission process; treatment strategy; tumor progression; tumorigenesis

Project Description Human papillomavirus (HPV) infections of the oral cavity or oropharynx cause about 25% of head and neck cancers (mainly oropharyngeal). The number of HPV-positive oropharyngeal cancers is expected to exceed that of cervical cancers by 2020. Given the role of HPV in oropharyngeal cancers, understanding the epidemiology and natural history of oral HPV infections is salient. Currently, however, such data are limited, and have been restricted almost exclusively to genital (alpha) HPV types. Extant studies suggest that oral HPV prevalence in healthy individuals is low, but likely underestimate the true prevalence of HPV infection in the oral cavity due to restriction to alpha HPV types. Recently, beta and gamma HPV types have been detected in the oral cavity of healthy men and HIV-positive men and women, suggesting a broader spectrum of tropism for these HPV genera. To our knowledge, the presence of gamma and beta HPV types has not been investigated in oral cavity samples from healthy women. There are also no data on sexual behavior determinants of gamma or beta infections in the oral cavity. Furthermore, while a hand-to-mouth route for gamma and beta HPV transmission has been postulated, it has never been explored. This proposal addresses the epidemiology of oral gamma and beta HPV infections among 409 healthy women, aged 30 to 50 years old. We propose to make efficient use of stored samples (including oral and fingernail tip samples) to address the following aims: 1) Estimate the prevalence of oral gamma and beta HPV infections; 2) Determine the concordance between oral and fingernail tip samples for detecting gamma and beta HPV types; and 3) Identify health and sexual behavior determinants of oral gamma and beta HPV infections. Our study also has the potential to identify novel oncogenic oral HPV types. The results of this exploratory study could inform the development of larger epidemiologic and natural history studies of gamma and beta HPV infections in the oral cavity, particularly as our knowledge of the role of these genera in oral tumorigenesis advances. Furthermore, our results will further our understanding of HPV tropism, with potential to contribute to our general understanding of HPV-related biology and mechanisms of transmission and infection.

项目描述 口腔或口咽部的人乳头瘤病毒 (HPV) 感染导致约 25% 的头颈部疾病 癌症（主要是口咽癌）。 HPV阳性口咽癌的数量预计将超过 到 2020 年，宫颈癌的发病率将达到这一水平。鉴于 HPV 在口咽癌中的作用，了解 口腔 HPV 感染的流行病学和自然史非常突出。但目前此类数据有限， 并且几乎仅限于生殖器 (α) HPV 类型。现有研究表明口腔 HPV 健康个体中的患病率较低，但可能低估了 HPV 感染在健康个体中的真实患病率 口腔由于 α HPV 类型的限制。最近，在 HPV 中检测到了 β 型和 γ 型 HPV。 健康男性和艾滋病毒阳性男性和女性的口腔，表明有更广泛的趋向性 这些 HPV 属。据我们所知，尚未对 HPV 类型的存在进行调查 健康女性的口腔样本中。也没有关于伽玛性行为决定因素的数据 或口腔内的β感染。此外，虽然 γ 和 β HPV 是从手到口的途径， 传输已经被假设，但从未被探索过。该提案涉及流行病学 409 名 30 至 50 岁健康女性的口腔 γ 和 β HPV 感染情况。我们建议 有效利用存储的样本（包括口腔和指甲尖样本）来实现以下目标：1) 估计口腔 HPV γ 和 β HPV 感染的流行率； 2）确定口语之间的一致性 用于检测 HPV γ 和 β 型的指甲尖样本； 3) 确定健康和性行为 口腔 γ 和 β HPV 感染的决定因素。我们的研究还有可能发现新颖的 致癌性口腔 HPV 类型。这项探索性研究的结果可以为更大的开发提供信息 口腔中 γ 型和 β 型 HPV 感染的流行病学和自然史研究，特别是 我们对这些属在口腔肿瘤发生中的作用的认识不断进步。此外，我们的结果将进一步 我们对 HPV 趋向性的了解，有可能有助于我们对 HPV 相关的一般了解 传播和感染的生物学和机制。