Epidemiology of oral gamma and beta HPV infections in mid-adult women

中成年女性口腔 γ 和 β HPV 感染的流行病学

• 批准号: 8636249
• 负责人: RACHEL L. WINER
• 金额: $ 7.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636249
• 关键词: Address; Adult; Age; Alcohol consumption; Anogenital cancer; Biological Assay; Biology; Consensus; DNA; Data; Dental Epidemiology; Development; Epidemiology; Genital system; HIV Seropositivity; Hand; Head and Neck Cancer; Health behavior; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunosuppression; Individual; Infection; Knowledge; Link; Malignant neoplasm of cervix uteri; Methods; Mouth Neoplasms; Natural History; Oncogenic; Oral; Oral Sex; Oral cavity; Oropharyngeal; Oropharyngeal Squamous Cell Carcinoma; Parents; Prevalence; Prevention strategy; Research; Role; Route; Sampling; Sex Behavior; Sexual Partners; Skin Cancer; Smoking; Structure of nail of finger; Tropism; Vagina; Viral Load result; Woman; aged; cigarette smoking; malignant mouth neoplasm; malignant oropharynx neoplasm; men; novel; oral HPV; oral carcinogenesis; oral tumorigenesis; public health relevance; transmission process; treatment strategy; tumor progression; tumorigenesis

Project Description Human papillomavirus (HPV) infections of the oral cavity or oropharynx cause about 25% of head and neck cancers (mainly oropharyngeal). The number of HPV-positive oropharyngeal cancers is expected to exceed that of cervical cancers by 2020. Given the role of HPV in oropharyngeal cancers, understanding the epidemiology and natural history of oral HPV infections is salient. Currently, however, such data are limited, and have been restricted almost exclusively to genital (alpha) HPV types. Extant studies suggest that oral HPV prevalence in healthy individuals is low, but likely underestimate the true prevalence of HPV infection in the oral cavity due to restriction to alpha HPV types. Recently, beta and gamma HPV types have been detected in the oral cavity of healthy men and HIV-positive men and women, suggesting a broader spectrum of tropism for these HPV genera. To our knowledge, the presence of gamma and beta HPV types has not been investigated in oral cavity samples from healthy women. There are also no data on sexual behavior determinants of gamma or beta infections in the oral cavity. Furthermore, while a hand-to-mouth route for gamma and beta HPV transmission has been postulated, it has never been explored. This proposal addresses the epidemiology of oral gamma and beta HPV infections among 409 healthy women, aged 30 to 50 years old. We propose to make efficient use of stored samples (including oral and fingernail tip samples) to address the following aims: 1) Estimate the prevalence of oral gamma and beta HPV infections; 2) Determine the concordance between oral and fingernail tip samples for detecting gamma and beta HPV types; and 3) Identify health and sexual behavior determinants of oral gamma and beta HPV infections. Our study also has the potential to identify novel oncogenic oral HPV types. The results of this exploratory study could inform the development of larger epidemiologic and natural history studies of gamma and beta HPV infections in the oral cavity, particularly as our knowledge of the role of these genera in oral tumorigenesis advances. Furthermore, our results will further our understanding of HPV tropism, with potential to contribute to our general understanding of HPV-related biology and mechanisms of transmission and infection.

项目描述 口腔或口咽的人乳头瘤病毒（HPV）感染约25％的头颈 癌症（主要是口咽）。 HPV阳性口咽癌的数量预计将超过 到2020年，颈癌的作用。鉴于HPV在口咽癌中的作用，了解 口服HPV感染的流行病学和自然史是显着的。但是，目前，此类数据是有限的 并且几乎仅限于生殖器（Alpha）HPV类型。现有的研究表明口服HPV 健康个体的患病率很低，但可能低估了HPV感染的真正患病率 由于限制了Alpha HPV类型而导致的口腔。最近，已经检测到Beta和Gamma HPV类型 健康男人和艾滋病毒阳性男性和女人的口腔，暗示着更广泛的向心论 这些HPV属。据我们所知，尚未研究伽马和βHPV类型的存在 在健康女性的口腔样品中。也没有有关伽马性行为行为决定因素的数据 或口腔中的β感染。此外，虽然是伽马和beta HPV的手到口径的路线 已经假设传输，从未探索过。该建议涉及 409名30至50岁的健康女性中的口腔伽玛和βHPV感染。我们建议 有效利用存储的样品（包括口服和指甲尖端样品）来解决以下目的：1） 估计口腔伽玛和βHPV感染的患病率； 2）确定口服之间的一致性 和指甲尖端样品用于检测伽玛和βHPV类型； 3）确定健康和性行为 口服伽马和βHPV感染的决定因素。我们的研究也有潜力识别新颖 致癌口服HPV类型。这项探索性研究的结果可能会为更大的发展提供信息 口腔中伽马和βHPV感染的流行病学和自然史研究，特别是 我们对这些属在口腔肿瘤发生进展中的作用的了解。此外，我们的结果将进一步 我们对HPV偏见的理解，有可能有助于我们对HPV相关的一般理解 传播和感染的生物学和机制。