Epidemiology of oral gamma and beta HPV infections in mid-adult women

中成年女性口腔 γ 和 β HPV 感染的流行病学

• 批准号: 8862363
• 负责人: RACHEL L. WINER
• 金额: $ 7.73万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8862363
• 关键词: Address; Adult; Age; Alcohol consumption; Anogenital cancer; Biological Assay; Biology; Consensus; DNA; Data; Dental Epidemiology; Development; Epidemiology; Genital system; HIV Seropositivity; Hand; Head and Neck Cancer; Health; Health behavior; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; Immunosuppression; Individual; Infection; Knowledge; Link; Malignant neoplasm of cervix uteri; Methods; Mouth Neoplasms; Natural History; Oncogenic; Oral; Oral Sex; Oral cavity; Oropharyngeal; Oropharyngeal Squamous Cell Carcinoma; Parents; Prevalence; Prevention strategy; Research; Role; Route; Sampling; Sex Behavior; Sexual Partners; Skin Cancer; Smoking; Structure of nail of finger; Tropism; Vagina; Viral Load result; Woman; aged; cigarette smoking; malignant mouth neoplasm; malignant oropharynx neoplasm; men; novel; oral HPV; oral carcinogenesis; oral tumorigenesis; transmission process; treatment strategy; tumor progression; tumorigenesis

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) infections of the oral cavity or oropharynx cause about 25% of head and neck cancers (mainly oropharyngeal). The number of HPV-positive oropharyngeal cancers is expected to exceed that of cervical cancers by 2020. Given the role of HPV in oropharyngeal cancers, understanding the epidemiology and natural history of oral HPV infections is salient. Currently, however, such data are limited, and have been restricted almost exclusively to genital (alpha) HPV types. Extant studies suggest that oral HPV prevalence in healthy individuals is low, but likely underestimate the true prevalence of HPV infection in the oral cavity due to restriction to alpha HPV types. Recently, beta and gamma HPV types have been detected in the oral cavity of healthy men and HIV-positive men and women, suggesting a broader spectrum of tropism for these HPV genera. To our knowledge, the presence of gamma and beta HPV types has not been investigated in oral cavity samples from healthy women. There are also no data on sexual behavior determinants of gamma or beta infections in the oral cavity. Furthermore, while a hand-to-mouth route for gamma and beta HPV transmission has been postulated, it has never been explored. This proposal addresses the epidemiology of oral gamma and beta HPV infections among 409 healthy women, aged 30 to 50 years old. We propose to make efficient use of stored samples (including oral and fingernail tip samples) to address the following aims: 1) Estimate the prevalence of oral gamma and beta HPV infections; 2) Determine the concordance between oral and fingernail tip samples for detecting gamma and beta HPV types; and 3) Identify health and sexual behavior determinants of oral gamma and beta HPV infections. Our study also has the potential to identify novel oncogenic oral HPV types. The results of this exploratory study could inform the development of larger epidemiologic and natural history studies of gamma and beta HPV infections in the oral cavity, particularly as our knowledge of the role of these genera in oral tumorigenesis advances. Furthermore, our results will further our understanding of HPV tropism, with potential to contribute to our general understanding of HPV-related biology and mechanisms of transmission and infection.

描述（由申请人提供）：口腔或口咽部的人乳头瘤病毒 (HPV) 感染导致约 25% 的头颈癌（主要是口咽癌）。预计到 2020 年，HPV 阳性口咽癌的数量将超过宫颈癌。鉴于 HPV 在口咽癌中的作用，了解口腔 HPV 感染的流行病学和自然史非常重要。然而，目前此类数据有限，并且几乎完全仅限于生殖器 (α) HPV 类型。现有研究表明，健康个体中口腔 HPV 患病率较低，但由于 α HPV 类型的限制，可能低估了口腔 HPV 感染的真实患病率。最近，在健康男性和 HIV 阳性男性和女性的口腔中检测到了 HPV 型 β 型和 HPV 型，这表明这些 HPV 属具有更广泛的趋向性。据我们所知，尚未在健康女性的口腔样本中调查是否存在 HPV 型 γ 和 β 型。也没有关于口腔 γ 或 β 感染的性行为决定因素的数据。此外，虽然已经假设 γ 和 β HPV 存在从手到口的传播途径，但从未对其进行过探索。该提案研究了 409 名 30 至 50 岁健康女性口腔 γ 和 β HPV 感染的流行病学。我们建议有效利用存储的样本（包括口腔和指甲尖样本）来实现以下目标： 1）估计口腔 γ 和 β HPV 感染的流行率； 2) 确定口腔和指甲尖样本检测γ和β HPV类型的一致性； 3) 确定口腔 γ 和 β HPV 感染的健康和性行为决定因素。我们的研究还有可能识别新型致癌口腔 HPV 类型。这项探索性研究的结果可以为口腔中 γ 和 β HPV 感染的更大规模流行病学和自然史研究的发展提供信息，特别是随着我们对这些属在口腔肿瘤发生中的作用的认识不断进步。此外，我们的结果将进一步加深我们对 HPV 趋向性的理解，有可能有助于我们对 HPV 相关生物学以及传播和感染机制的一般理解。