Effects of tobacco cut and nicotine form on the abuse liability of moist snuff

烟丝和尼古丁形式对湿鼻烟滥用倾向的影响

基本信息

批准号：
10587196
负责人：
Brittney L Keller-Hamilton
金额：
$ 17.79万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10587196
关键词：
Accounting Address Adolescent Adult Affect Analytical Chemistry Appalachian Region Area Behavior Biometry Cardiovascular Diseases Characteristics Crossover Design Data Analyses Dependence Development Disease Disparity Dose Dryness Epidemiology Equity Evaluation Experimental Designs Foundations Genus Mentha Goals Health Disparities Research High Prevalence Human Industry Inequity Knowledge Laboratories Length Malignant Neoplasms Manufacturer Marketing Mentorship Methods Nicotine Nicotine Dependence Ohio Oral Tobacco Oral health Outcome Participant Persons Plant Leaves Population Prevalence Public Health Randomized Regulation Research Sales Scientist Smokeless Tobacco Speed Standardization Testing Tobacco Tobacco Dependence Tobacco Industry Tobacco use Training Underserved Population United States Variant Youth absorption abuse liability addiction addiction liability base cohort design health disparity health inequalities laboratory experiment male population based secondary analysis smokeless tobacco addiction smokeless tobacco use smokeless tobacco user snuff snus social factors tobacco advertising tobacco flavor tobacco products tobacco regulatory science toxicant young adult

Accounting Address Adolescent Adult Affect Analytical Chemistry Appalachian Region Area Behavior Biometry Cardiovascular Diseases Characteristics Crossover Design Data Analyses Dependence Development Disease Disparity Dose Dryness Epidemiology Equity Evaluation Experimental Designs Foundations Genus Mentha Goals Health Disparities Research High Prevalence Human Industry Inequity Knowledge Laboratories Length Malignant Neoplasms Manufacturer Marketing Mentorship Methods Nicotine Nicotine Dependence Ohio Oral Tobacco Oral health Outcome Participant Persons Plant Leaves Population Prevalence Public Health Randomized Regulation Research Sales Scientist Smokeless Tobacco Speed Standardization Testing Tobacco Tobacco Dependence Tobacco Industry Tobacco use Training Underserved Population United States Variant Youth absorption abuse liability addiction addiction liability base cohort design health disparity health inequalities laboratory experiment male population based secondary analysis smokeless tobacco addiction smokeless tobacco use smokeless tobacco user snuff snus social factors tobacco advertising tobacco flavor tobacco products tobacco regulatory science toxicant young adult

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项目摘要

PROJECT ABSTRACT For decades, the tobacco industry has manipulated moist snuff (i.e., dip) to become as appealing and addictive as possible. These manipulations have resulted in moist snuff accounting for 90% of the smokeless tobacco (SLT) market share in the United States and have slowed progress in reducing the prevalence of SLT use. The public health burden of the tobacco industry’s actions has not been equitable; males living in Appalachian regions of the United States continue to use SLT at high rates, leading to regional inequities in cardiovascular disease, cancer, and poor oral health. The goal of this research is to identify local, state, and/or federal regulations for moist snuff that reduce its addiction potential. This research will evaluate two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential: length of tobacco cut (long vs. fine) and nicotine form (low vs. high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Building on the PI’s areas of expertise and providing crucially-needed training, evaluations of tobacco cut and nicotine form will be done epidemiologically, using analytical chemistry, and using experimental human laboratory methods. For the epidemiological evaluation, we will complete a secondary data analysis of recent population-based cohorts to evaluate associations between level of SLT dependence and product characteristics (i.e., cut, flavor, brand) of moist snuff used by adolescents and adults in Appalachian Ohio. For the analytical chemistry evaluation, we will quantitate the levels of total nicotine and FBN present in moist snuff products used by adolescent and adult participants in our Appalachian Ohio cohorts; these characteristics of products will be compared according to level of SLT dependence of the user as well as other product features (e.g., tobacco cut and flavor). For the human laboratory evaluation, we will use a 2x2 within-subjects cross-over design to test how moist snuff use (amount and duration), nicotine delivery, and appeal differ according to variations in cut (long vs. fine) and level of FBN (low vs. high). We will also evaluate whether the association between style of moist snuff and outcomes varies according to level of SLT dependence. Participants will be adults who live in Appalachian Ohio and are daily moist snuff users. Altogether, this research will provide a foundation for understanding the characteristics of moist snuff used in Appalachia—where the burden of SLT use remains stubbornly high—and the effects that regulations on tobacco cut and nicotine form could have on reducing health inequities in this region. The conduct of this research and implementation of the proposed training plan will also provide the PI, a promising scientist with strong foundations in epidemiology and biostatistics, Appalachian health disparities research, and other areas of tobacco regulatory science with needed training in addiction research, tobacco product evaluation, and human laboratory experimental designs.

项目摘要几十年来，烟草业一直操纵湿鼻烟（即蘸酱）变得吸引人和上瘾尽可能。这些操纵导致湿润的鼻烟占无烟烟草的90％（SLT）在美国的市场份额，并减慢了降低SLT使用率的进展。烟草业行动的公共卫生伯恩（Burnen）尚未公平。居住在阿巴拉契亚地区的男性美国继续以高速使用SLT，导致心血管疾病的区域不平等，癌症和口腔健康状况不佳。这项研究的目的是确定本地，州和/或联邦法规潮湿的鼻烟，降低了其成瘾的潜力。这项研究将评估湿鼻烟的两个特征，这是关键烟草业和成瘾潜力的驱动因素的操纵目标：烟草切割长度（长）和尼古丁形式（自由基本形式中的低水平与高水平的尼古丁）。烟草切成薄片和更高的烟草自由碱尼古丁（FBN）的水平会导致更快，更大的尼古丁递送。在PI的专业领域建立并提供全面需要的培训，将对烟草切割和尼古丁形式进行评估在流行病学上，使用分析化学和使用实验性人类实验室方法。为了流行病学评估，我们将完成对最新基于人群的同伙的二级数据分析评估SLT依赖水平与产品特征（即剪切，风味，品牌）之间的关联俄亥俄州阿巴拉契亚的青少年和成年人使用的湿鼻烟。对于分析化学评估，我们将量化青少年和成人使用的湿鼻烟产品中存在的总尼古丁和FBN的水平我们阿巴拉契亚俄亥俄州同伙的参与者；这些产品的这些特征将根据用户以及其他产品功能（例如烟草切割和风味）的SLT依赖水平。为了人类实验室评估，我们将使用2x2内部的跨越设计来测试湿鼻烟的使用方式（数量和持续时间），尼古丁交付和根据剪切的变化（长与罚款）和水平的差异不同 FBN（低与高）。我们还将评估湿鼻烟的风格与结果之间的关联根据SLT依赖的水平进行变化。参与者将是居住在俄亥俄州阿巴拉契亚的成年人每天潮湿的鼻烟用户。总之，这项研究将为理解特征提供基础阿巴拉契亚使用的潮湿鼻烟（SLT使用的伯恩在这里仍然顽固地很高）以及所带来的影响关于减少该地区健康不平等的烟草切割和尼古丁形式的法规。行为在拟议的培训计划的研究和实施中，还将提供PI，这是一个应许科学家在流行病学和生物统计学，阿巴拉契亚健康差异研究和其他方面具有很大的基础在成瘾研究，烟草产品评估和人类实验室实验设计。