Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan

绘制青春期和整个生命周期饮酒的神经生物学风险和后果

• 批准号: 10733406
• 负责人: Louise Mewton
• 金额: $ 23.95万
• 依托单位: UNIVERSITY OF SYDNEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733406
• 关键词: Accounting; Address; Adolescence; Adolescent; Adolescent Development; Adult; Age; Aging; Alcohol consumption; Alcohols; Behavioral; Biometry; Brain; Cessation of life; Chronic; Code; Data; Data Set; Development; Developmental Process; Elderly; Follow-Up Studies; Growth; Hospitalization; Image; Incidence; International; Knowledge; Life; Longevity; Longitudinal cohort study; Machine Learning; Maps; Memory; Methodology; Methods; Modeling; Neurobiology; Neurosciences; Outcome; Pathway interactions; Pattern; Persons; Pharmaceutical Preparations; Positioning Attribute; Probability; Psychopathology; Recurrence; Research; Research Personnel; Risk; Sample Size; Sampling; Techniques; Testing; Time; Twin Multiple Birth; adolescent alcohol risk; alcohol consequences; alcohol effect; alcohol intervention; alcohol prevention; alcohol use disorder; alcohol use initiation; biobank; brain health; causal model; cognitive development; cognitive training; cohort; data harmonization; design; developmental disease; drinking; drinking onset; human old age (65+); innovation; middle age; model design; neurodevelopment; neuroimaging; neuroregulation; novel; open data; substance use; symptomatology; underage drinking; young adult

PROJECT SUMMARY/ABSTRACT Globally, 1.34 billion people consume alcohol in harmful amounts, with alcohol use accounting for 1.78 million deaths in 2020. Alcohol use often begins, and noticeably escalates, throughout adolescence. Incidence of alcohol use disorder (AUD) and related symptomatology follows a similar pattern, peaking between the ages of 18 and 20 years. As such, AUD has been described as a “developmental disorder” of young adulthood. While rates of problematic drinking are highest among young adults, recent years have seen large increases in problematic drinking among older adults, with corresponding increases in AUD and alcohol-related hospitalizations. The developmental processes contributing to alcohol use disorders (AUD) have long been recognised but there remain substantial gaps in our knowledge about the neurobiological predictors of “milestones” along the pathway to AUD, as well as the neurobiological consequences of alcohol use throughout adolescence into midlife and older age. Our overarching aim is to therefore uncover the neurobiological risks of adolescent alcohol use and distinguish these from the consequences of alcohol use in adolescence and across the lifespan. This will be done within a developmental framework and conducted with a focus on replicability and rigorous causal modelling. To address our aim, we need large-scale longitudinal assessments of alcohol use, capturing the peak period of adolescent risk, and incorporating comprehensive other substance use, behavioral, environmental, and imaging data. Data from the Adolescent Brain and Cognitive Development (ABCD) Study therefore provide an unprecedented opportunity to address our aim. To extend our examination of the consequences of alcohol use across the lifespan, we will combine (or harmonize) ABCD data with large-scale, high quality cohort data from different life stages and jointly analyze these data to establish the neurobiological predictors and consequences of alcohol use at key periods across the lifespan within a unified framework. This project represents innovation in its: 1) developmental approach to the relationship between alcohol use and neurobiology which focuses on adolescence but also extends across the lifespan into older adulthood; 2) harmonization of data across four landmark datasets across the lifespan; 3) methodological rigor focusing on the promotion of causal inference; 4) the application of neuroimaging and biostatistical techniques that are unique to the research team; and (5) focus on replicability and the open science framework, including preregistration of all analyses and publicly available code. Outcomes from this project will have the potential to provide novel neurobiological targets for medication development, as well as alcohol preventions and interventions informed by neuroscience. We will also take the first steps towards the establishment of a larger international consortium of longitudinal cohort studies focused on the impact of alcohol use on brain health across the lifespan.

项目摘要/摘要 在全球范围内，有13.4亿人以有害量消耗酒精，饮酒占178万 2020年的死亡。在整个青春期中，饮酒经常开始，并且显着升级。发病率 酒精使用障碍（AUD）和相关症状学遵循类似的模式，在年龄之间达到顶峰 18年和20年。因此，AUD被描述为年轻成年的“发育障碍”。尽管 有问题的饮酒率在年轻人中最高，近年来有很大的增长 老年人饮酒有问题，与AUD和酒精有关的相应增加 住院。长期以 公认但我们对神经生物学预测指标的知识仍然存在很大的差距 沿通往AUD的途径的“里程碑”以及整个酒精使用的神经生物学后果 青少年进入中年和年龄较大。我们的总体目的是揭示神经生物学 青少年饮酒的风险，并将其与饮酒的后果区分开 青少年和整个寿命。这将在一个发展框架内完成，并与 专注于复制性和严格的因果建模。要解决我们的目标，我们需要大规模的纵向 评估饮酒，捕获青少年风险的高峰期并增加全面 其他物质使用，行为，环境和成像数据。来自青少年大脑的数据 因此，认知发展（ABCD）研究为解决我们的目标提供了前所未有的机会。到 扩展我们对整个寿命中饮酒后果的检查，我们将结合（或协调） 来自不同生活阶段的大规模，高质量队列数据的ABCD数据，将这些数据共同分析 在整个生命周期中建立饮酒的神经生物学预测因素和后果 在统一框架内。该项目在其以下方面代表了创新：1） 酒精使用与神经生物学之间的关系，重点关注青少年，但也遍及整个 寿命成年； 2）整个寿命的四个地标数据集的数据协调； 3） 方法论上的严格重点是促进因果推论； 4）神经影像的应用和 研究团队独有的生物统计技术； （5）专注于可复制性和开放科学 框架，包括所有分析和公开代码的预注册。这个项目的结果将 有潜力为药物开发提供新颖的神经生物学靶标 神经科学告知的预防和干预措施。我们还将迈出第一步 建立更大的国际纵向队列研究联盟，重点是酒精的影响 在整个生命周期中使用大脑健康。