CONFERENCE ON WOUND REPAIR AND FIBROBLASTS

伤口修复和成纤维细胞会议

• 批准号: 3433766
• 负责人: CHARLES Frederick FOX
• 金额: $ 1万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-15 至 1992-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433766
• 关键词: fibroblasts; meeting /conference /symposium; molecular biology; travel; wound healing

Advancements in the molecular biology of growth factors, growth factor receptors, and cell/matrix receptors and the appreciation that these proteins have contextual and combinational effects on cell function have allowed investigators to form rather elaborate hypotheses as to how wound repair processes may evolve and regress. The recent availability of probes for these proteins and their effector functions has given the investigator tools with which to test these hypotheses and to search for mechanisms by which dysregulated repair may lead to nonhealing wounds or fibrotic disease. Gradually the external signals that modulate cell phenotype during tissue repair and the intracellular controls of this phenotypic modulation will become elucidated. By drawing investigators together from diverse fields, it is hoped that this meeting will speed our understanding of wound repair and thereby facilitate beneficial intervention in nonhealing wounds and fibrotic disease.

生长因子分子生物学的进步，生长因子 受体和细胞/基质受体以及这些 蛋白质对细胞功能具有上下文和组合作用 允许研究人员形成相当详尽的假设 维修过程可能会发展和回归。 最近的可用性 这些蛋白质及其效应功能的探针给出了 研究人员的工具可以测试这些假设并搜索 通过调节失调的机制可能导致伤口非彻底的伤口或 纤维化疾病。 逐渐调制单元的外部信号 组织修复期间的表型和此的细胞内对照 表型调制将被阐明。 通过绘画调查员 从不同的领域共同希望这次会议能加快 我们对伤口修复的理解，从而促进有益 干预非治疗伤口和纤维化疾病。