Core--Research Translation

核心--研究翻译

• 批准号: 7064116
• 负责人: JAMES Edward TROSKO
• 金额: $ 18.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064116
• 关键词: Internet; aromatic hydrocarbon receptor; benzofurans; biomedical facility; carbopolycyclic compound; dioxins; environmental contamination; environmental exposure; halobiphenyl /halotriphenyl compound; meeting /conference /symposium; molecular biology

The Research Translation Core has planned a series of activities that will include collaborations with government agencies, meetings and new websites providing technology transfer and communication to a broad audience as suggested by the SBRP RFA. We have initiated the recruitment of a group of cooperators that include federal and state agencies in Michigan and New Jersey and industrial consortiums in the same states. These documented cooperating units have indicated their interest in participating in technology transfer and we will continue to recruit new cooperators using the same methods we have employed to date. An annual one-day meeting with representatives of the cooperating institutions will be held in which selected projects will present highlights of their research progress. Cooperators will be asked to present their views of research needs in the areas of site remediation and health risk analysis. A generous amount of time will be set aside for individual and group discussions in an attempt to foster agreements and resolve differences. In addition, an international symposium on computational and modeling approaches will be held to enhance the understanding and extent of the health threat from environmental contamination. This activity will be supported using funds from a variety of sources. The meeting will enrich our proposed research program which emphasizes the computational system biology approach spanning from molecule to intact organisms. This approach promises more accurate predictability of impacts on human health resulting from exposure to TCDD-like environmental contaminants. In a different and innovative approach to research translation, a set of molecular tools for use in identifying the capacity of microbial consortia to degrade hazardous chemicals in the environment will be developed in specific projects and cores of the research program. These molecular tools will be placed in a data repository including a website open for public use. The website will contain a variety of tools developed by investigators in this and other programs. These tools will be maintained and kept up to date by incorporating new information as it emerges from our own effort as well that of others. A tutorial will be produced to inform users and instruct them on the use of the tools and information in the repository. This activity will serve research scientists, biodegradation engineers and administrators to make more rapid progress in developing strategies to decontaminate and detoxify sites containing hazardous chemicals.

研究翻译核心计划了一系列活动，其中包括与 向政府机构、会议和新网站提供技术转让和交流 正如 SBRP RFA 所建议的广泛受众。我们已开始招募一批 合作者包括密歇根州和新泽西州的联邦和州机构以及工业财团 在相同的州。这些备案合作单位均表示有兴趣参与 技术转让，我们将继续使用我们现有的方法招募新的合作者 受雇至今。每年与合作机构代表举行为期一天的会议 选定的项目将在会上展示其研究进展的亮点。合作者将被询问 提出他们对场地修复和健康风险分析领域的研究需求的看法。一个 将留出大量时间进行个人和小组讨论，以促进 达成协议并解决分歧。此外，还举办了一场关于计算和 将采用建模方法来加强对健康威胁的理解和程度 环境污染。这项活动将得到多种来源的资金支持。这 会议将丰富我们提出的研究计划，重点是计算系统生物学 从分子到完整有机体的方法。这种方法保证了更准确的可预测性 接触 TCDD 类环境污染物对人类健康造成的影响。 在研究翻译的不同和创新方法中，一套用于识别的分子工具 微生物联合体降解环境中危险化学品的能力将在 研究计划的具体项目和核心。这些分子工具将被放置在数据中 存储库，包括开放供公众使用的网站。该网站将包含由以下人员开发的各种工具 该项目和其他项目的调查员。这些工具将通过合并来维护并保持最新 从我们自己以及其他人的努力中产生的新信息。将制作一个教程来告知 用户并指导他们使用存储库中的工具和信息。本次活动将服务 研究科学家、生物降解工程师和管理人员在开发方面取得更快的进展 对含有危险化学品的场所进行净化和解毒的战略。