Protein Folding in the Cell

细胞中的蛋白质折叠

• 批准号: 7160205
• 负责人: RICHARD I MORIMOTO
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-10 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7160205
• 关键词: cell biology; interdisciplinary collaboration; meeting /conference /symposium; molecular pathology; protein folding; travel

DESCRIPTION (provided by applicant): We request funding to support the 2006 Federation of American Society of Experimental Biologists (FASEB) Summer Conference on "Protein Folding in the Cell" to be held July 29 to August 3, 2006 in Saxtons River, VT. The proposed conference will be the ninth in a series of highly successful FASEB Conferences on this topic. This meeting has been unique in its goal to bring together cell biologists/geneticists, biophysicists/biochemists, and mathematical modelers to tackle the complex problems of protein folding and misfolding and implications for human disease. This was the concept behind the first conference in 1990, and it remains a unique opportunity for scientists from very diverse backgrounds. Most protein folding conferences consider either the theoretical and in vitro aspects of folding or the role of molecular chaperones and protein folding catalysts in the cell. However, the need for interdisciplinary approaches is stronger than ever. The cell biological approaches have progressed to where reaching a mechanistic understanding is crucial, and biological constraints play a critical role in formulating theory and interpreting in vitro data. In addition to examining recent advances in in vitro folding and molecular chaperone mechanism, this meeting will focus on the latest developments in the mechanisms of protein folding and misfolding, and the related cellular processes of protein synthesis, sorting and translocation through the cell and across membranes, macromolecular assembly, and protein degradation. Whereas past "Protein Folding in the Cell" meetings have alternated between emphases on in vitro folding and biophysical topics or cellular aspects of folding in vivo, a new aspect of the 2006 meeting will be to integrate these topics. Common themes include diseases of protein conformation including neurodegenerative diseases, amyloidoses, and cystic fibrosis and how the proteins implicated in these diseases have provided insights into the protein quality control machinery and on the intrinsic properties of folding, misfolding, and assembly into oligomers and fibrils. Finding therapeutic strategies requires a fundamental understanding of the behavior of the polypeptide chain and the cellular environment and constraints imposed on it. Our goal through this meeting is to bring together physical and biological scientists in an interactive environment, to promote education and understanding of the approaches, experimental limitations and to explore common interests. The small size and isolated setting of this meeting with all participants residing and taking their meals in close proximity promotes optimal scientific exchange. The conference format will provide extensive arenas for informal discussions. Poster sessions will allow all participants to interact scientifically with other investigators. Young investigators and women will be well-represented among speakers and encouraged to attend the conference.

描述（由申请人提供）：我们要求资金支持2006年美国实验生物学家协会联合会（FASEB）夏季关于“细胞中蛋白质折叠”的夏季会议，将于7月29日至2006年8月3日在佛蒙特州萨克斯顿河举行。拟议的会议将是有关该主题的一系列非常成功的FaseB会议的第九名。这次会议的目标是将细胞生物学家/遗传学家，生物物理学家/生物化学家和数学建模者汇集在一起​​，以解决蛋白质折叠，错误折叠以及对人类疾病的影响的复杂问题。这是1990年第一次会议的背后概念，对于来自非常不同背景的科学家来说，它仍然是一个独特的机会。大多数蛋白质折叠会议都考虑折叠的理论和体外方面，或者分子伴侣和蛋白质折叠催化剂在细胞中的作用。但是，对跨学科方法的需求比以往任何时候都更强大。细胞生物学方法已经发展到达到机械理解的地方至关重要，生物学约束在制定理论和解释体外数据中起着至关重要的作用。除了检查体外折叠和分子伴侣机制的最新进展外，这次会议还将重点介绍蛋白质折叠和错误折叠机制的最新发展，以及蛋白质合成，通过细胞和跨膜，跨膜，大分子组合和蛋白质脱脂的蛋白质合成，分类和易位的相关细胞过程。尽管过去的“细胞中蛋白质折叠”会议在体外折叠和生物物理主题或体内折叠的细胞方面之间进行了交替，但2006年会议的一个新方面将是整合这些主题。常见的主题包括蛋白质构象的疾病，包括神经退行性疾病，淀粉样蛋白和囊性纤维化，以及与这些疾病有关的蛋白质如何提供了对蛋白质质量控​​制机制以及折叠，错误折叠，折叠，和纤维纤维的内在特性的见解。寻找治疗策略需要对多肽链的行为以及对其施加的细胞环境和约束的基本了解。我们通过这次会议的目标是在互动环境中汇集物理和生物科学家，以促进对方法，实验限制并探索共同利益的教育和理解。这次会议的小规模和孤立的设置与所有居住的参与者居住并在近距离接近餐点促进了最佳科学交流。会议格式将为非正式讨论提供广泛的领域。海报会议将使所有参与者能够与其他研究人员进行科学互动。年轻的调查人员和妇女将在演讲者中得到很好的代表，并鼓励参加会议。