Comparative Approaches to Bio-knowledge Discovery

生物知识发现的比较方法

基本信息

批准号：
6902530
负责人：
JUNHYONG KIM
金额：
$ 39.63万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-01 至 2007-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6902530
关键词：
bioinformatics biomedical equipment purchase biomedical facility computational biology computer center computer program /software computer system hardware evolution functional /structural genomics interdisciplinary collaboration literature survey meeting /conference /symposium molecular biology information system neoplasm /cancer education sickle cell anemia training

项目摘要

DESCRIPTION (provided by applicant): In this planning grant to establish a Program of Excellence in Biomedical Computing, the University of Pennsylvania and the Children's Hospital of Philadelphia propose to develop a new organization that will serve as a central conduit of biomedical computing research tying together the activities of three schools and six research institutes. The organization will consist of a scientific steering committee with internal and external members to oversee research activities, an oversight committee to provide institutional support, an executive committee to govern day-to-day activities, and an office of education to coordinate the training activities. The organizational structure will be generated under the umbrella of the Penn Genomics Institute and the Penn Center for Bioinformatics to leverage existing resources. Interdisciplinary research interactions will be promoted by funding 12 new seed grants (made possible by matching funds) focusing on comparative approaches to biomedical knowledge discovery. In the first year, four projects will be funded: (1) pattern discovery in comparative genomics; (2) computational phylogeny reconstruction; (3) comparative text mining for cancer research; and (4) comparative informatics approach to sickle-cell disease. In subsequent years, new projects will be added to the first four through an internal solicitation for proposals. The Scientific Steering Committee will review these proposals and four new projects will be funded in Years 2 and 3. Each year, existing projects will be reviewed and at the end of the planning grant, all projects will be reviewed for consolidation into a small number of high impact projects. New interactions between existing computational faculty and biomedical faculty will be encouraged by holding opportunity presentation retreats to introduce researchers from complementary fields to biological problems and computational methods. Faculty basic education seminars will be held monthly where basic concepts like "transcription" will be discussed in a highly interactive format. The existing core facility for bioinformatics will be augmented with additional high-performance computing hardware, support for teaching basic computational biology tools, and a facility to coordinate dissemination of software tools developed from this grant. An existing PhD level training program in biomedical computing will be supplemented to provide research experience for undergraduates and masters students.

描述（由申请人提供）：在这项旨在建立生物医学计算卓越计划的规划拨款中，宾夕法尼亚大学和费城儿童医院提议建立一个新组织，作为生物医学计算研究的中心渠道三所学校和六个研究所的活动。该组织将由一个由内部和外部成员组成的科学指导委员会（负责监督研究活动）、一个提供机构支持的监督委员会、一个管理日常活动的执行委员会以及一个协调培训活动的教育办公室组成。该组织结构将在宾夕法尼亚大学基因组研究所和宾夕法尼亚大学生物信息学中心的领导下产生，以利用现有资源。将通过资助 12 项新的种子基金（通过匹配资金实现）来促进跨学科研究互动，重点关注生物医学知识发现的比较方法。第一年将资助四个项目：（1）比较基因组学的模式发现； (2)计算系统发育重建； (3)癌症研究的比较文本挖掘； (4)镰状细胞病的比较信息学方法。在随后的几年中，将通过内部提案征集将新项目添加到前四个项目中。科学指导委员会将审查这些提案，并在第二年和第三年资助四个新项目。每年，现有项目都将受到审查，在规划拨款结束时，所有项目都将接受审查，以合并为少数项目。高影响力项目。通过举办机会演讲务虚会，向研究人员介绍互补领域的生物学问题和计算方法，将鼓励现有计算教师和生物医学教师之间的新互动。教师基础教育研讨会将每月举行一次，以高度互动的形式讨论“转录”等基本概念。现有的生物信息学核心设施将通过额外的高性能计算硬件、对基本计算生物学工具教学的支持以及协调由这笔赠款开发的软件工具的传播的设施来增强。现有的生物医学计算博士级培训计划将得到补充，为本科生和硕士生提供研究经验。