JOINT CONFERENCE ON MUSCLE AND CARDIOVASCULAR BIOLOGY

肌肉和心血管生物学联合会议

• 批准号: 3433764
• 负责人: CHARLES Frederick FOX
• 金额: $ 0.85万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-23 至 1992-01-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433764
• 关键词: cell differentiation; cytoskeletal proteins; gene expression; meeting /conference /symposium; myocardium; myogenesis; regulatory gene; striated muscles; synaptogenesis; travel

Identification and isolation of a matrix of regulatory genes governing commitment to skeletal myogenesis represents a pivotal breakthrough in vertebrate biology that is beginning to open the door to a more general understanding of the processes governing mammalian cell determination and stability of differentiation. The function and relevance of each member of this regulatory gene family to in vitro and in vivo myogenesis remains to be elucidated and should provide a forum for substantial debate since the findings have stimulated considerable interest and attracted many researchers to the field. The major problems on which the meeting will focus are: 1. The relevance of cell history, homeobox genes and pattern formation in the developmental progression from mesodermal precursor to determine myoblast. 2. The cell and molecular biology of commitment to the myogenic lineage. 3. Tissue and stage specific regulation of contractile protein gene expression. 4. The molecular biology of synaptogenesis. 5. The molecular pathogenesis of neuromuscular disease.

识别和隔离调节基因的基因 对骨骼肌发生的承诺代表了一个关键的突破 脊椎动物生物学开始打开更通用的门 了解有关哺乳动物细胞确定的过程和 分化的稳定性。 每个成员的功能和相关性 这个调节性基因家族对体外和体内肌发生仍然存在 阐明，应该为大量辩论提供一个论坛，因为 调查结果激发了很大的兴趣，并吸引了许多 研究人员到该领域。 会议的主要问题 重点是： 1。细胞史，同源基因和模式的相关性 从中胚层前体到发育进展的形成 确定肌细胞。 2。对肌原性的命名的细胞和分子生物学 血统。 3。收缩蛋白基因的组织和分期特定调节 表达。 4。突触发生的分子生物学。 5。神经肌肉疾病的分子发病机理。