CONFERENCE ON CYTOKINES AND THEIR RECEPTORS

细胞因子及其受体会议

• 批准号: 3433595
• 负责人: CHARLES Frederick FOX
• 金额: $ 0.3万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433595
• 关键词: biological signal transduction; cytokine; cytokine receptors; gene expression; growth /development; hematopoiesis; immunogenetics; immunoregulation; meeting /conference /symposium; travel

Perhaps no other sub-specialty within immunology has advanced more rapidly in the past ten years than has the molecular characterization of cytokines and their receptors. Countless poorly defined soluble activities have now been shown to be associated with discrete gene products which function to control not only the development of immune reactivity, but the maintenance of all aspects of hematopoiesis as well. Attention has continued to focus on this field as many cytokines have been tested both preclinically and clinically and have been shown to manifest profound effects on restoration and maintenance of immune function in a host of clinical conditions. Recently, several of the genes which code for specific cytokine receptors have been identified. Through continued application of genetic engineering, soluble versions of several receptors have been produced and have been shown to modulate immune reactivity both in vitro and in vivo. Furthermore, elucidation of the structure of both cytokines and their receptors has opened this area of cell biology as an unequalled system in which to study the mechanisms behind signal transduction and the molecular control of growth and differentiation. Although recent activity surrounding cytokines and their receptors was the topic of isolated symposium at several major scientific meetings, no single symposium (save the International Lymphokine Workshop, which is held every three-years, alternately in Europe and the United States) is devoted to an in-depth review and discussion of the entire field from basic investigation through to examination of the effects of molecules in clinical studies. It is hoped that the proposed program would provide a unique forum in which investigators involved with all aspects of cytokine characterization and response - from biochemists concerned with mechanisms behind signal transduction, to cell biologists interested in the pathways of differentiation, to cellular immunologists focussed in the diversity and reactivity of immune response networks, to clinicians interested in manipulation of host immune reactivity in health and disease - can meet to discuss the intricacies and similarities behind cytokine dependent immune response pathways.

也许免疫学中没有其他副特质进展得更快 在过去的十年中，细胞因子的分子表征 和他们的受体。 现在有无数定义的可溶性活动 被证明与离散基因产物有关 不仅控制免疫反应性的发展，而且控制维护 造血的各个方面。 注意继续集中 在该领域，由于许多细胞因子都已临时测试和 在临床上，已显示出对恢复的深远影响 并在许多临床条件下维持免疫功能。 最近，为特定细胞因子受体编码的几个基因 已经确定了。 通过继续应用遗传 工程学，几种受体的可溶性版本， 已显示出在体外和体内调节免疫反应性。 此外，阐明了细胞因子及其结构 受体已开放了该细胞生物学领域，作为一个无与伦比的系统 要研究信号转导和分子背后的机制 控制生长和分化。 尽管围绕细胞因子及其受体的最近活动是 在几次大型科学会议上的孤立研讨会的主题，没有一个 研讨会（节省国际淋巴动物研讨会，每次举行 三年，在欧洲和美国交替）致力于 从基本调查中对整个领域的深入审查和讨论 通过检查分子在临床研究中的影响。 它 希望该建议的计划将提供一个独特的论坛 参与细胞因子表征和 响应 - 来自与信号背后机制有关的生物化学家 转导向对途径感兴趣的细胞生物学家 分化，分化为细胞免疫学家，专注于多样性和 免疫反应网络的反应性，对感兴趣的临床医生 操纵宿主在健康和疾病中的免疫反应性 - 可以达到 讨论细胞因子依赖性免疫背后的复杂性和相似性 响应途径。