CONFERENCE ON PROTEIN FOLDING AND DESIGN

蛋白质折叠和设计会议

• 批准号: 3435122
• 负责人: CHARLES Frederick FOX
• 金额: $ 0.3万
• 依托单位: KEYSTONE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-15 至 1992-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435122
• 关键词: meeting /conference /symposium; protein folding; protein structure function

How do proteins fold into their unique three-dimensional structures? How does the three dimensional structure of a protein give rise to function? Can proteins be designed, either from first principles or through reconstruction of natural protein substructures? Can low molecular weight and highly stable mimics of natural proteins be designed? This meeting will describe progress towards understanding these questions that lie at the heart of modern molecular biology. In-recent years folding motifs have been recognized in a variety of gene regulatory proteins, and their structures are being determined by a combination of predictive methods, NMR, and crystallography. Considerable progress with the folding problem has been made in vitro studies as well as whole cells. Enormous progress has been made in understanding the structures and functions of membrane proteins. We have begun to study and manipulate the repertoire of biological molecular recognition using immunoglobulins and related molecules. This meeting should bring together chemists, molecular biologists, and cellular biologists to review recent advances in these areas, and discuss the future of this multidisciplinary field.

蛋白质如何折叠成独特的三维结构？如何 蛋白质的三维结构是否产生功能？ 可以从第一原理或通过 自然蛋白质亚结构的重建？可以低分子量 设计天然蛋白质的高度稳定模仿？这次会议 将描述了解这些问题的进度 现代分子生物学的心脏。 折叠折叠图案 在各种基因调节蛋白中都得到了认可，它们 结构是通过预测方法的组合来确定的 NMR和晶体学。 折叠问题的进展很大 已经在体外研究和全细胞中进行了。 巨大的进步 已经在理解膜的结构和功能方面做出了 蛋白质。 我们已经开始研究和操纵 使用免疫球蛋白和相关的生物分子识别 分子。 这次会议应该汇集化学家，分子 生物学家和蜂窝生物学家回顾这些最新进展 区域，讨论这个多学科领域的未来。