FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology

FASEB 夏季研究会议，肺表面活性剂：分子和细胞生物学

• 批准号: 7161264
• 负责人: Samuel Hawgood
• 金额: $ 3.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161264
• 关键词: cell biology; meeting /conference /symposium; molecular biology; pulmonary surfactants; travel

DESCRIPTION (provided by applicant): The overall objective of this conference is to provide a forum for the exchange of new and cutting-edge information regarding the basic molecular and cellular biology of fetal lung development and differentiation of surfactant producing cells, mechanisms in the regulation of synthesis, trafficking and secretion of surfactant lipids and proteins. The conference also will emphasize the pathophysiology of the surfactant system, with regard to protein misfolding and disease, lung injury and repair. We believe that this meeting is unique and highly important, because in addition to inviting speakers who are recognized experts in the surfactant field, we have included renowned experts working in different but related areas to provide in-depth information on topics of stem cell biology and organogenesis, protein misfolding, organelle biogenesis and trafficking and host defense. The specific topics covered include: 1. Genetic control of lung development 2. Organelle biogenesis and the pathophysiology that results from structural alterations of surfactant proteins in human lung diseases. 3. Regulation of lung epithelial plasticity, regeneration, and repair. 4. Molecular pathogenesis of human lung diseases associated with abnormal lung development of mutations in the surfactant proteins. 5. Collectins and mucosal host defense. 6. Design of novel surfactant-based therapeutics.

描述（由申请人提供）： 本次会议的总体目标是提供一个交流新的和前沿信息的论坛，涉及胎肺发育和表面活性剂产生细胞分化的基本分子和细胞生物学，表面活性剂合成、运输和分泌的调节机制。表面活性剂脂质和蛋白质。会议还将强调表面活性剂系统的病理生理学，涉及蛋白质错误折叠和疾病、肺损伤和修复。我们相信这次会议是独特且非常重要的，因为除了邀请表面活性剂领域公认的专家发言外，我们还邀请了在不同但相关领域工作的知名专家，以提供有关干细胞生物学和干细胞生物学等主题的深入信息。器官发生、蛋白质错误折叠、细胞器生物发生和运输以及宿主防御。 涵盖的具体主题包括： 1. 肺发育的基因控制 2. 人类肺部疾病中表面活性蛋白结构改变导致的细胞器生物发生和病理生理学。 3.肺上皮可塑性、再生和修复的调节。 4. 与表面活性蛋白突变的肺发育异常相关的人类肺部疾病的分子发病机制。 5. 集合素和粘膜宿主防御。 6.新型表面活性剂疗法的设计。