RETINAL SPECTROFLUOROMETER

视网膜荧光分光计

• 批准号: 2651389
• 负责人: Bruce M Ishimoto
• 金额: $ 9.21万
• 依托单位: OCUMETRICS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1999-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651389
• 关键词: biomedical equipment development; clinical biomedical equipment; fluorescence; human subject; lipofuscin; microspectrophotometry; retina

DESCRIPTION: The investigator goal is to develop a commercial instrument for measuring and characterizing intrinsic fluorescence (autofluorescence) in the retina. This instrument will make it possible to broaden the research connecting lipofuscin - the dominant retinal fluorophore - with aging, age related macular degeneration (AMD), and several juvenile retina degenerations. Lipofuscin also is thought to reflect oxidative damage to the retina and its quantification would provide a cumulative index of oxidative damage to the retina. The Pi sees a market for such a device among retinal researchers and pharmaceutical companies. Furthermore, an instrument designed specifically for retinal spectrofluorometry will allow the study of other retial fluorophores (collagen, drusen, flavi proteins) as well as open the possibility of quantitative studies using exogenous fluorescent markers (fluorescein , ICG, BPD, etc). PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：研究者的目标是开发广告 用于测量和表征内在荧光的仪器 （自动荧光）在视网膜中。 该乐器将使之可能 扩大连接脂肪霉素的研究 - 主要的视网膜 荧光团 - 随着年龄相关的黄斑变性（AMD），并且 几个少年视网膜变性。 脂肪霉素也被认为 反映对视网膜的氧化损害，其定量将 为视网膜提供氧化损伤的累积指数。 pi 在视网膜研究人员和 制药公司。 此外，一种设计的乐器 专门用于视网膜光谱法将允许研究 其他保留荧光团（胶原蛋白，drusen，Flavi蛋白）以及 使用外源荧光开放定量研究的可能性 标记（荧光素，ICG，BPD等）。 拟议的商业应用程序：不可用