Medical Imaging Technology Development Core

医学影像技术开发核心

• 批准号: 10573274
• 负责人: Hong Liu
• 金额: $ 45.46万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-15 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573274
• 关键词: Address; Algorithmic Software; Area; Biomedical Engineering; Cancer Center; Centers of Research Excellence; Characteristics; Cities; Clinical; Clinical Research; Collaborations; Collection; Communities; Computer Assisted; Computer software; Computers; Consumption; Custom; Data; Dedications; Development; Devices; Doctor of Philosophy; Educational workshop; Emerging Technologies; Engineering; Equipment; Evaluation Research; Fluorescence; Foundations; Funding; Future; Goals; Image; Imaging Device; Imaging Techniques; Imaging technology; Industry; Infrastructure; Interdisciplinary Study; Laboratories; Laboratory Research; Leadership; Learning; Learning Module; Libraries; Machine Learning; Medical Imaging; Medical Informatics; Medical center; Medicine; Methods; Mission; Multimodal Imaging; Oklahoma; Outcome; Patients; Phase; Phenotype; Physicians; Pilot Projects; Reader; Reading; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Roentgen Rays; Scheme; Series; Services; Software Tools; Solid; Surveys; System; Testing; Time; Training; Translational Research; Universities; Work; X-Ray Medical Imaging; anticancer research; college; cost; cost effective; deep learning; design; digital pathology; experience; flexibility; image processing; imaging biomarker; imaging facilities; imaging informatics; imaging modality; imaging study; improved; informatics tool; innovation; interest; machine learning model; machine learning prediction; meetings; member; new technology; operation; optical imaging; programs; quantitative imaging; radiomics; research and development; synergism; technology development; tomography; tool; transfer learning; translational cancer research; tumor; Address; Algorithmic Software; Area; Biomedical Engineering; Cancer Center; Centers of Research Excellence; Characteristics; Cities; Clinical; Clinical Research; Collaborations; Collection; Communities; Computer Assisted; Computer software; Computers; Consumption; Custom; Data; Dedications; Development; Devices; Doctor of Philosophy; Educational workshop; Emerging Technologies; Engineering; Equipment; Evaluation Research; Fluorescence; Foundations; Funding; Future; Goals; Image; Imaging Device; Imaging Techniques; Imaging technology; Industry; Infrastructure; Interdisciplinary Study; Laboratories; Laboratory Research; Leadership; Learning; Learning Module; Libraries; Machine Learning; Medical Imaging; Medical Informatics; Medical center; Medicine; Methods; Mission; Multimodal Imaging; Oklahoma; Outcome; Patients; Phase; Phenotype; Physicians; Pilot Projects; Reader; Reading; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Roentgen Rays; Scheme; Series; Services; Software Tools; Solid; Surveys; System; Testing; Time; Training; Translational Research; Universities; Work; X-Ray Medical Imaging; anticancer research; college; cost; cost effective; deep learning; design; digital pathology; experience; flexibility; image processing; imaging biomarker; imaging facilities; imaging informatics; imaging modality; imaging study; improved; informatics tool; innovation; interest; machine learning model; machine learning prediction; meetings; member; new technology; operation; optical imaging; programs; quantitative imaging; radiomics; research and development; synergism; technology development; tomography; tool; transfer learning; translational cancer research; tumor

ABSTRACT – Medical Imaging Technology Development Core The objective of the Medical Imaging Technology Development Core (MITDC) is to build an infrastructure to support research of the junior research project leaders (RPLs) and overarching goal of this COBRE. The Core will be built based on the OU Advanced Medical Imaging Center (OU-AMIC), which has been supported by both the Gallogly College of Engineering University of Oklahoma (OU) Norman campus and the Stephenson Cancer Center of OUHSC campus since 2012. OU-AIMC includes 5 research laboratories and an established network between the engineering and clinical expertise to facilitate the interdisciplinary research. OU-AIMC provides a solid foundation for this MITDC to provide important resource for RPLs and pilot project awardees of the COBRE. The MITDC Core has 3 Specific Aims. Aim 1: We will implement an interdisciplinary management plan to build an optimal infrastructure to support translational medical imaging related cancer research. The Core will be co- directed by an experienced engineer and a physician researcher. An advisory board of senior engineering and physician researchers will be established to guide the development and operation of the Core. Existing imaging equipment and other tools will be integrated to serve COBRE projects, along with equipment and services available by industry and clinical collaboration. Monthly brainstorming meetings, on demand tours, round table discussions, and biannual open house workshops will facilitate interaction between members of the Core and researchers on both OU Norman and OUHSC campuses. These activities will allow the Core to better understand researcher needs and provide opportunities for researchers to learn new imaging technologies that can benefit their research. Aim 2: We will design and develop a series of investigative imaging tools and testbeds to provide researchers fast and cost-effective methods to test their innovative research concepts. Using testbeds of new imaging modalities, the researchers will be able to acquire preliminary data to validate their hypotheses without the expensive and time-consuming development of a fully equipped laboratory. Based on the research areas of the initially selected RPL projects and other junior researchers in the COBRE pool, the testbeds will include, but are not limited to, phase-contrast X-ray imaging, X-ray fluorescence tomography, digital pathology scanners, and special optical imaging devices. Aim 3: We will build an integrated computer server/network and provide new computer-aided quantitative image feature analysis schemes and software to support the RPLs and other researchers to conduct large data and deep transfer learning-based Radiomics studies. This will improve the efficiency and consistency of developing and validating quantitative image markers and/or machine learning prediction models developed by different projects. In summary, MITDC will provide a unique research service and supporting capability to enhance the overarching goal of this COBRE. It will not merely be a collection of imaging equipment in a distinct space, it will also allow us to fully network our current research expertise to better support the translational cancer research using medical imaging technology to benefit patients in the future.

摘要 - 医学成像技术开发核心 医学成像技术开发核心（MITDC）的目的是建立一个基础设施 支持初级研究项目领导者（RPLS）和该毛绒的总体目标的研究。核心 将基于OU高级医学成像中心（OU-AMIC）建造，这两者都支持 俄克拉荷马州工程大学盖洛格利大学（OU）诺曼校园和斯蒂芬森癌症 自2012年以来，OUHSC校园中心。OU-AIMC包括5个研究实验室和一个已建立的网络 在工程和临床专业知识之间，以促进跨学科研究。 OU-AIMC提供了 该MITDC的​​坚实基础为Cobre的RPL和试点项目获奖者提供重要资源。 MITDC核心具有3个具体目标。目标1：我们将实施跨学科管理计划来建立 一种支持翻译医学成像相关的癌症研究的最佳基础设施。核心将是共同的 由经验丰富的工程师和物理研究人员执导。高级工程咨询委员会和 将建立物理研究人员来指导核心的开发和运作。现有成像 设备和其他工具将被整合以提供山脉项目以及设备和服务 可通过行业和临床合作获得。每月头脑风暴会议，按需旅行，圆桌会议 讨论和双年度开放日研讨会将有助于核心成员之间的互动 OU Norman和OUHSC校园的研究人员。这些活动将使核心能够更好地理解 研究人员需要并为研究人员提供机会学习可以受益的新成像技术 他们的研究。目标2：我们将设计并开发一系列调查成像工具和测试床以提供 研究人员快速且具有成本效益的方法来测试其创新研究概念。使用新的测试床 成像方式，研究人员将能够获取初步数据以验证其假设而没有 设备齐全的实验室的昂贵且耗时的开发。基于 最初选定的RPL项目和毛绒池中的其他初级研究人员，测试床将包括但 不限于相位对比X射线成像，X射线荧光断层扫描，数字病理学扫描仪， 和特殊的光学成像设备。 AIM 3：我们将构建一个集成的计算机服务器/网络并提供 新的计算机辅助定量图像特征分析方案和软件，以支持RPL和其他 研究人员进行大型数据和深度转移学习的放射线学研究。这将改善 开发和验证定量图像标记和/或机器学习的效率和一致性 由不同项目开发的预测模型。总而言之，MITDC将提供独特的研究服务 并支持增强该鞋底总体目标的能力。这不仅是 在独特空间中的成像设备，它还可以使我们能够完全建立我们当前的研究专业知识以更好 使用医学成像技术支持翻译癌症研究，以使患者受益。