Medical Imaging Technology Development Core

医学影像技术开发核心

基本信息

批准号：
10334983
负责人：
Hong Liu
金额：
$ 45.27万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-15 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10334983
关键词：
Address Algorithmic Software Area Biomedical Engineering Cancer Center Centers of Research Excellence Characteristics Cities Clinical Clinical Research Collaborations Collection Communities Computer Assisted Computer software Computers Consumption Custom Data Development Devices Doctor of Philosophy Educational workshop Emerging Technologies Engineering Equipment Evaluation Research Fluorescence Foundations Funding Future Goals Image Imaging Device Imaging Techniques Imaging technology Industry Infrastructure Interdisciplinary Study Laboratories Laboratory Research Leadership Learning Learning Module Libraries Machine Learning Medical Imaging Medical center Medicine Methods Mission Multimodal Imaging Oklahoma Outcome Patients Phase Phenotype Physicians Pilot Projects Reader Reading Research Research Personnel Research Project Grants Research Support Resource Sharing Resources Roentgen Rays Scheme Series Services Software Tools Solid Surveys System Testing Time Training Translational Research Universities Work X-Ray Medical Imaging anticancer research base college cost cost effective deep learning design digital pathology experience flexibility image processing imaging biomarker imaging facilities imaging informatics imaging modality imaging study improved informatics tool innovation interest machine learning model machine learning prediction meetings member new technology operation optical imaging programs quantitative imaging radiomics research and development synergism technology development tomography tool transfer learning translational cancer research tumor

项目摘要

ABSTRACT – Medical Imaging Technology Development Core The objective of the Medical Imaging Technology Development Core (MITDC) is to build an infrastructure to support research of the junior research project leaders (RPLs) and overarching goal of this COBRE. The Core will be built based on the OU Advanced Medical Imaging Center (OU-AMIC), which has been supported by both the Gallogly College of Engineering University of Oklahoma (OU) Norman campus and the Stephenson Cancer Center of OUHSC campus since 2012. OU-AIMC includes 5 research laboratories and an established network between the engineering and clinical expertise to facilitate the interdisciplinary research. OU-AIMC provides a solid foundation for this MITDC to provide important resource for RPLs and pilot project awardees of the COBRE. The MITDC Core has 3 Specific Aims. Aim 1: We will implement an interdisciplinary management plan to build an optimal infrastructure to support translational medical imaging related cancer research. The Core will be co- directed by an experienced engineer and a physician researcher. An advisory board of senior engineering and physician researchers will be established to guide the development and operation of the Core. Existing imaging equipment and other tools will be integrated to serve COBRE projects, along with equipment and services available by industry and clinical collaboration. Monthly brainstorming meetings, on demand tours, round table discussions, and biannual open house workshops will facilitate interaction between members of the Core and researchers on both OU Norman and OUHSC campuses. These activities will allow the Core to better understand researcher needs and provide opportunities for researchers to learn new imaging technologies that can benefit their research. Aim 2: We will design and develop a series of investigative imaging tools and testbeds to provide researchers fast and cost-effective methods to test their innovative research concepts. Using testbeds of new imaging modalities, the researchers will be able to acquire preliminary data to validate their hypotheses without the expensive and time-consuming development of a fully equipped laboratory. Based on the research areas of the initially selected RPL projects and other junior researchers in the COBRE pool, the testbeds will include, but are not limited to, phase-contrast X-ray imaging, X-ray fluorescence tomography, digital pathology scanners, and special optical imaging devices. Aim 3: We will build an integrated computer server/network and provide new computer-aided quantitative image feature analysis schemes and software to support the RPLs and other researchers to conduct large data and deep transfer learning-based Radiomics studies. This will improve the efficiency and consistency of developing and validating quantitative image markers and/or machine learning prediction models developed by different projects. In summary, MITDC will provide a unique research service and supporting capability to enhance the overarching goal of this COBRE. It will not merely be a collection of imaging equipment in a distinct space, it will also allow us to fully network our current research expertise to better support the translational cancer research using medical imaging technology to benefit patients in the future.

摘要 – 医学影像技术开发核心医学成像技术开发核心（MITDC）的目标是建立一个基础设施支持初级研究项目负责人 (RPL) 的研究以及 COBRE 核心的总体目标。将以OU高级医学影像中心（OU-AMIC）为基础建设，该中心得到了双方的支持俄克拉荷马大学加洛格利工程学院 (OU) 诺曼校区和史蒂芬森癌症中心自 2012 年起成为 OUHSC 校园中心。OU-AIMC 包括 5 个研究实验室和一个已建立的网络 OU-AIMC 为促进跨学科研究提供了工程和临床专业知识之间的联系。为 MITDC 为 RPL 和 COBRE 试点项目获奖者提供重要资源奠定了坚实的基础。 MITDC 核心有 3 个具体目标 1：我们将实施跨学科管理计划来建立。支持转化医学成像相关癌症研究的最佳基础设施将是共同的。由经验丰富的工程师和医师研究员指导。将设立医师研究人员来指导现有成像的开发和运营。将集成设备和其他工具以及设备和服务来为 COBRE 项目提供服务通过行业和临床合作提供每月头脑风暴会议、按需参观、圆桌会议。讨论和一年两次的开放日研讨会将促进核心成员和 OU 诺曼和 OUHSC 校区的研究人员这些活动将使核心更好地了解。研究人员需要并为研究人员提供学习新成像技术的机会，这些技术可以受益目标 2：我们将设计和开发一系列研究成像工具和测试平台，以提供研究人员使用新的测试平台快速且经济高效地测试他们的创新研究概念。成像方式，研究人员将能够获得初步数据来验证他们的假设，而无需基于研究领域的设备齐全的实验室的昂贵且耗时的开发。测试平台将包括最初选择的 RPL 项目和 COBRE 池中的其他初级研究人员，但是不限于相衬 X 射线成像、X 射线荧光断层扫描、数字病理扫描仪、目标3：我们将建立一个集成的计算机服务器/网络并提供。新的计算机辅助定量图像特征分析方案和软件以支持 RPL 和其他研究人员进行基于大数据和深度迁移学习的放射组学研究，这将改善放射组学研究。开发和验证定量图像标记和/或机器学习的效率和一致性综上所述，MITDC将提供独特的研究服务。和支持能力来增强 COBRE 的总体目标。它不仅仅是一个集合。成像设备在一个独特的空间，它也将使我们能够充分网络我们当前的研究专业知识，以更好地支持利用医学成像技术进行转化癌症研究，以造福未来的患者。