Biocontainment Research Support Service(s) Core-Optional

生物防护研究支持服务核心-可选

基本信息

批准号：
10792753
负责人：
Sixto Manuel Leal
金额：
$ 84.2万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10792753
关键词：
Air Alabama Anesthesia procedures Autopsy Avian Influenza Award Biomedical Research COVID-19 pandemic Cell Culture Techniques Cell Line Cell Separation Cells Clinical Collaborations Consultations Containment Core Facility Coronavirus Decontamination Development Diagnostic tests Drug Delivery Systems Encephalitis Viruses Equilibrium Equine Encephalomyelitis Equipment Evaluation Flow Cytometry Fostering Funding Genetically Modified Organisms Genotype High Resolution Computed Tomography Histoplasma Human Immune response Immunology In Vitro Individual Infection Institutional Review Boards Investments Laboratories Laboratory Research Light Liquid substance Lung Microbe Microbiology Microscopy Mission Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Nebulizer Organism Output Plaque Assay Positron-Emission Tomography Productivity Pulmonary function tests Recovery Research Research Infrastructure Research Support Resolution Resources Risk Sampling Scientist Senior Scientist Services Solid Strategic Planning System Technology Translating Translational Research Universities Variant Venezuelan Equine Encephalomyelitis Virus Work X-Ray Computed Tomography animal imaging biobank biodefense bioluminescence imaging career preparation chikungunya exhaust experimental study fluorescence imaging fungus future outbreak future pandemic genetically modified cells high resolution imaging high throughput screening imaging facilities imaging platform in vitro Assay in vivo in vivo imaging innovation insight live cell imaging medical countermeasure microbial new pandemic non-invasive imaging novel operation pandemic potential pandemic preparedness repaired research clinical testing single cell analysis single photon emission computed tomography skills tissue processing ultra high resolution

项目摘要

Project Summary/Abstract: Core 3 outlines a strategic plan to establish integrated core services within the UAB SEBLAB enabling safe and efficient use of the cutting edge scientific equipment recently funded by NIAID award 1G20AI167409-S1. This proposal establishes six functional integrated research cores within containment including: 1. Cell Culture core to maintain and generate novel cell lines, 2. Microbiology core to culture organisms, modify, and maintain stocks, 3. In vitro core to operate high resolution imaging and high-throughput screening platforms, 4. In vivo core to operate high complexity non-invasive imaging platforms, 5. Single Cell core to perform flow cytometry, cell sorting, and single cell partitioning, and 6. Pandemic Preparedness core to develop medical countermeasures and drive IRB-approved high containment research requiring clinical samples. Each core will be operated by a scientific research team, including the PI on this application, one senior scientist, and two junior scientists. This scientific team will work closely with UAB Core lab directors, Biosafety, and SEBLAB end users to optimize high containment research productivity.

项目摘要/摘要：核心3概述了在UAB Seblab中建立综合核心服务的战略计划实现了最近由NIAID资助的尖端科学设备的安全有效利用奖励1G20AI167409-S1。该建议建立了六个功能综合研究核心在控制内包括：1。细胞培养核维持和生成新的细胞系，2。微生物学对培养生物的核心，修饰和维持库存，3。在体外核心运行高分辨率成像和高通量筛选平台，4。在体内核心高度运行复杂性非侵入性成像平台，5。单细胞核进行流式细胞术，细胞分类和单细胞分配，以及6。大流行准备核心以发展医学对策并推动IRB批准的高遏制研究，需要临床样本。每个核心将由科学研究团队（包括此应用程序的PI）操作，一位高级科学家和两名初级科学家。这个科学团队将与UAB紧密合作核心实验室导演，生物安全和Seblab最终用户，以优化高遏制研究生产率。