Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support

提高 SEBLAB 研究生产力、运营和核心实验室支持

基本信息

批准号：
10792750
负责人：
Sixto Manuel Leal
金额：
$ 269.17万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10792750
关键词：
Air Alabama Avian Influenza Award Biomedical Research COVID-19 pandemic Cell Culture Techniques Cell Line Cell Separation Cells Collaborations Containment Core Facility Coronavirus Decontamination Development Encephalitis Viruses Equilibrium Equine Encephalomyelitis Equipment Flow Cytometry Fostering Funding Histoplasma Human Resources In Vitro Individual Information Technology Institution Investments Laboratories Laboratory Research Leadership Maintenance Microbiology Mycobacterium tuberculosis National Institute of Allergy and Infectious Disease Occupational Medicine Organism Output Police Productivity Recovery Research Research Support Risk Scientist Security Services Solid Specialist Specimen Strategic Planning System Technology Training Training Programs Translating Translational Research Universities Venezuelan Equine Encephalomyelitis Work animal resource biobank biodefense career preparation chikungunya exhaust fungus future outbreak high resolution imaging high throughput screening imaging platform in vivo innovation laboratory facility medical countermeasure medical specialties new pandemic non-invasive imaging novel operation pandemic potential pandemic preparedness programs repaired research facility skills symposium training opportunity webinar

项目摘要

Project Summary The UAB Southeastern Biocontainment Laboratory (SEBLAB) is one of 12 Regional Biocontainment Laboratories (RBL) established by NIAID to advance BSL-3 research and pandemic preparedness. In continuous operation since 2009, NIAID award 1G20AI167409-01 enabled the repair of natural wear and tear on non- scientific equipment and essential upgrades to air balance, exhaust, energy recovery, and decontamination systems. Subsequently, NIAID award 1G20AI167409-S1 enabled the acquisition of cutting edge scientific equipment. The current proposal outlines a strategic plan to safely and effectively translate these investments into increased research productivity and innovative ground-breaking scientific discoveries. Core-1 outlines facility operations support, personnel support, and replacement of essential basic scientific equipment required for SEBLAB to foster safe and productive high containment research programs. Core-2 seeks to support a solid and effective biosafety workforce, external training opportunities, and development and implementation of high quality internal training programs critical to the safe execution of high containment research. Core-3 outlines a strategic plan to establish integrated core services within containment enabling the safe and efficient use of cutting edge technologies, optimized research productivity, and ground-breaking scientific innovation/s. Upon completion, this project will achieve the following: 1) Support SEBLAB facility operational expenses; 2) Fund the leadership, administrative, and technical staff required to operate this high complexity facility, 3) Replace existing basic scientific equipment, 4) Support high quality BSL-3 biosafety training, 5) Establish integrated research cores within high containment, 6) Optimize and boost SEBLAB scientific research productivity, 7) Foster RBL/NBL network collaboration, and 8) Fund and maintain a highly skilled BSL-3 scientific workforce ready to rapidly respond at the frontline of emerging pandemic threats.

项目概要 UAB 东南生物防护实验室 (SEBLAB) 是 12 个区域生物防护实验室之一 NIAID 建立的实验室 (RBL) 旨在推进 BSL-3 研究和大流行病防范。连续中自 2009 年运行以来，NIAID 奖 1G20AI167409-01 能够修复非科学设备和空气平衡、排气、能量回收和净化的必要升级系统。随后，NIAID 奖项 1G20AI167409-S1 使得获得尖端科学设备。当前的提案概述了安全有效地转化这些投资的战略计划提高研究生产力和创新突破性科学发现。核心 1 概述设施运营支持、人员支持以及必要的基本科学设备的更换 SEBLAB 致力于促进安全且高效的高遏制研究项目。 Core-2 寻求支持一个坚实的和有效的生物安全劳动力、外部培训机会以及高水平的开发和实施高质量的内部培训计划对于安全执行高遏制研究至关重要。 Core-3 概述了制定战略计划，在遏制范围内建立综合核心服务，以便安全有效地利用尖端技术、优化的研究生产力和突破性的科学创新。之上完成后，该项目将实现以下目标： 1) 支持 SEBLAB 设施运营费用； 2) 资助运营这个高度复杂的设施所需的领导、行政和技术人员，3) 替换现有的基础科学设备，4) 支持高质量的 BSL-3 生物安全培训，5) 建立综合研究高遏制内的核心，6) 优化和提高 SEBLAB 科学研究生产力，7) 促进 RBL/NBL 网络协作，以及 8) 资助并维持一支高技能的 BSL-3 科学队伍，做好准备在新出现的流行病威胁的第一线迅速做出反应。