RETINAL SPECTROFLUOROMETER

视网膜荧光分光计

• 批准号: 6017020
• 负责人: Bruce M Ishimoto
• 金额: $ 37.59万
• 依托单位: OCUMETRICS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6017020
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; fluoresceins; fluorescence spectrometry; human subject; lipofuscin; portable biomedical equipment; retina; retinal pigment epithelium

DESCRIPTION: (Adapted from the Investigator's Abstract) Our goal is to develop a commercial instrument for measuring and characterizing intrinsic fluorescence (autofluorescence) in the retina. This instrument will make it possible to broaden the research connecting lipofuscin-the dominant retinal fluorophore-with aging, age related macular degeneration (AMD), and several juvenile retinal degenerations. Lipofuscin also is thought to reflect oxidative damage to the retina and its quantification would provide a cumulative index of oxidative damage to the retina. It will also be possible to measure macular pigment which is thought to have a protective role in ocular physiology. We see a market for such a device among retinal researchers and pharmaceutical companies. Furthermore, an instrument designed specifically for retinal spectrofluorometry will allow the study of other retinal fluorophores (collagen, drusen, flavi proteins) as well as open the possibility of quantitative studies using exogenous fluorescent markers (fluorescein, IDG, BPD, etc). Long term, we see the possibility that this technology could be used to screen for risk for AMD, and monitor the effectiveness of treatment. PROPOSED COMMERCIAL APPLICATION: The proposed commercial application is as a research instrument designed to measure lipofuscin concentrations in selected areas of the retina.

描述：（根据调查人员的摘要改编）我们的目标是开发 用于测量和表征内在荧光的商业仪器 （自动荧光）在视网膜中。该乐器将使 扩大连接脂肪霉素的研究 - 主要的视网膜 荧光团，衰老，与年龄相关的黄斑变性（AMD）和几个 少年视网膜变性。脂肪霉素也被认为反映了氧化 视网膜及其量化的损害将提供一个累积指数 视网膜的氧化损伤。也可以测量黄斑 颜料被认为在眼部生理中具有保护作用。 我们在视网膜研究人员和药品中看到了这种设备的市场 公司。此外，一种专门为视网膜设计的仪器 光谱荧光测定法将允许研究其他视网膜荧光团 （胶原蛋白，德鲁森，弗拉维蛋白），并打开可能性 使用外源荧光标记物（荧光素，IDG，， BPD等）。 长期，我们看到该技术可用于筛查的可能性 出于AMD的风险，并监控治疗的有效性。 拟议的商业应用： 拟议的商业应用是一种研究工具，旨在衡量 视网膜选定区域的脂肪霉素浓度。