Adipose Tissue and Metabolic Health

脂肪组织和代谢健康

• 批准号: 10391373
• 负责人: Thale Cross Jarvis
• 金额: $ 1.68万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391373
• 关键词: Academia; Adipocytes; Adipose tissue; Biology; Cells; Collaborations; Colorado; Development; Endocrine; Epidemic; Etiology; Fatty acid glycerol esters; Fishes; Health; Hormones; Immune; Industry; Inflammation; Inflammatory; Knowledge; Lipids; Location; Mentors; Metabolic; Metabolic Diseases; Metabolism; Methodology; MicroRNAs; Modeling; Obesity; Outcome; Physiology; Research; Research Personnel; Science; Scientist; Tissue Expansion; Vesicle; adipocyte biology; clinical practice; cytokine; design; exosome; fly; improved; insight; interest; pandemic disease; paracrine; peptide hormone; posters; programs; prospective; response; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Adipose Tissue and Metabolic Health, organized by Drs. Jacqueline M. Stephens and Antonio J. Vidal-Puig. The conference will be held in Keystone, Colorado from February 6-9, 2022. Like the Obesity and Type 2 epidemics, our understanding of adipocytes and adipose tissue biology continues to expand. Substantial research advances have led to new insights into the contributions of adipose tissue to normal physiology and obesity-related complications, which places adipocyte biology at the epicenter of a global pandemic of metabolic diseases. This Keystone Symposia conference will consider the locations and functions of different adipose tissue depots, as well as recent studies that use stable isotopies to provide insight into how formation and turnover of adipocytes contributes to metabolic disease. The secretory capacities of adipose tissue will be covered in several different sessions including Influences of Adipose Tissue Immune Cells and New Adipose Tissue Products-Exosomes and Lipid Containing Vesicle. Arguably one of the most significant discoveries in the last two decades of adipocyte research, is that adipocytes not only release endocrine hormones, but fat cells and adipose tissue secrete a variety of effectors, including exosomes, miRNA, lipids, inflammatory cytokines, and peptide hormones that act in both paracrine and endocrine capacities to impact local and systemic metabolic responses. Hence, talks on inflammation, metabolically healthy fat, and adipose tissue expansion are also covered in this program. In addition, this conference will also include a session on alternate models (flies, fish, and worms) that are currently used to study adipose tissue and metabolic diseases. Overall, the program for this conference will be highly informative to research scientists in academia and industry who have an interest in the contribution of adipose tissue to metabolic disease states.

抽象的 请求支持题为“脂肪组织和代谢健康”的 Keystone 研讨会， 由博士组织。杰奎琳·M·斯蒂芬斯和安东尼奥·J·维达尔-普伊格。会议将在基斯通举行， 科罗拉多州，2022 年 2 月 6 日至 9 日。 与肥胖和 2 型流行病一样，我们对脂肪细胞和脂肪组织生物学的理解仍在继续 扩大。大量的研究进展使我们对脂肪组织对健康的贡献有了新的认识。 正常生理和肥胖相关并发症，这将脂肪细胞生物学置于一个中心 代谢性疾病的全球流行。本次 Keystone 研讨会将考虑地点和 不同脂肪组织库的功能，以及最近使用稳定同位素的研究 深入了解脂肪细胞的形成和周转如何导致代谢疾病。秘书室 脂肪组织的能力将在几个不同的会议中讨论，包括脂肪组织的影响 免疫细胞和新的脂肪组织产品——外泌体和含脂囊泡。可以说是其中之一 过去二十年脂肪细胞研究中最重要的发现是，脂肪细胞不仅释放 内分泌激素，但脂肪细胞和脂肪组织分泌多种效应物，包括外泌体， 在旁分泌和内分泌中发挥作用的 miRNA、脂质、炎症细胞因子和肽激素 影响局部和全身代谢反应的能力。因此，从代谢角度讨论炎症 该计划还涵盖健康脂肪和脂肪组织扩张。此外，本次大会还将 还包括关于目前用于研究脂肪的替代模型（苍蝇、鱼和蠕虫）的会议 组织和代谢疾病。总体而言，本次会议的计划对于研究来说将提供丰富的信息 对脂肪组织对代谢的贡献感兴趣的学术界和工业界科学家 疾病状态。