Magnetic Resonance Elastography

磁共振弹性成像

• 批准号: 10321678
• 负责人: Richard L. Ehman
• 金额: $ 39.75万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-05 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10321678
• 关键词: 3-Dimensional; Acoustics; Algorithms; Anisotropy; Awareness; Basic Science; Biological Markers; Biopsy; Brain; Brain Diseases; Breast; Cancer Detection; Cell physiology; Cells; Clinical Research; Complex; Computer software; Data; Data Set; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Engineering; Environment; Evaluation; Evolution; Fibrosis; Frequencies; Generations; Goals; Grant; Health; Hepatic; Image; Imaging Techniques; Imaging technology; Inflammation; Lighting; Liver; Liver Fibrosis; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mechanics; Medical; Medicine; Methods; Modality; Modeling; Modulus; Morphologic artifacts; Motion; Motivation; Muscle; Organ; Patient Care; Patients; Performance; Periodicity; Physiologic pulse; Pilot Projects; Population; Prevalence; Process; Property; Protocols documentation; Reproducibility; Research; Research Personnel; Resolution; Rheology; Role; System; Techniques; Technology; Testing; Time; Tissue Model; Tissues; Translating; Translations; Validation; Work; base; chronic liver disease; clinical application; clinical diagnostics; clinical practice; clinically relevant; computerized data processing; design; elastography; flexibility; geometric structure; image reconstruction; improved; in vivo; innovation; liver biopsy; mechanical properties; mechanotransduction; motion sensitivity; nanometer; noninvasive diagnosis; novel; public health relevance; quantitative imaging; response; technology development; tool; volunteer

 DESCRIPTION (provided by applicant): Many disease processes cause profound changes in the mechanical properties of tissue, providing motivation for developing technologies to measure these properties for diagnostic purposes. In addition, over the last decade there has been growing awareness of the importance of tissue matrix mechanics on cellular function. Cells react to the dynamic and static properties of their matrix environment through mechanotransduction and cytoskeletal remodeling. It is now known that mechanobiology has an important role in the origin and evolution of many disease processes, including fibrosis and cancer. The goal of this research is to develop advanced MRI-based technologies for quantitatively assessing the mechanical properties of tissue and to explore and translate high-impact clinical and research applications. MR Elastography (MRE) is based on the principle that propagating mechanical waves reflect the properties of their medium. Shear waves are generated in the body and imaged with MRI techniques that have the remarkable ability to depict cyclic motions as small as 100 nanometers. The data are processed with inversion algorithms to provide cross-sectional images quantitatively depicting mechanical properties such as the complex shear modulus. In the last grant cycle, the hepatic MRE technology developed under this grant was successfully translated into wide clinical practice and is now used in patient care at hundreds of medical facilities around the world. Liver fibrosis is an important health problem with a rising prevalence in the US population. For many patients, MRE provides a safer, more comfortable, and less expensive alternative to liver biopsy for diagnosing this condition. Research has revealed many other promising applications, including noninvasive diagnosis of fibrosis and inflammation in other organs, detection and characterization of malignancies, providing new biomarkers to assess brain disease, and as a tool in basic research mechanobiology at the tissue and organ scales. As in the last grant cycle, the primary focus of the work will continue to be advanced technology development, to enable further basic and clinical research in this promising field, as well as to conduct pilot studies to identify clincal applications, and to develop practical protocols that will allow validation and eventual translatio to MRE to clinical practice. The research plan involves theoretical work, basic MRI pulse sequence development, device engineering, and protocol testing studies with normal and patient volunteers. Innovative approaches will be implemented and evaluated for generating mechanical waves in tissue, acquiring image data, and processing to generate quantitative images depicting previously inaccessible biomarkers. These technologies will be integrated into protocols that can be shared with other investigators and used to explore the practicality and value of promising applications.

 描述（通过施用）：许多疾病在组织的机械性能中，衡量这些静脉曲张的目的。基于定量的技术评估组织的机械性能，将高影响力的临床和研究应用转化为100纳米。在上一个赠款周期中，UCH是肝脏的剪切量，在世界各地的数百个医疗机构中，都在使用AL的疗法。为研究提供了一种更安全，更舒适，更小的替代肝活检的替代方法，揭示了许多其他有前途的应用，对恶性肿瘤的检测和表征，提供了新的生物标志物来评估脑部疾病问题和器官量表。 Wilk的工作重点将继续是先进的技术开发，以便在此进行进一步的基础研究和临床研究，以确定clincal应用程序的实用方案。 ，涉及工作，基本的MRI脉冲发展和协议测试研究，并评估LL，并评估在以前无法访问的生物标志物中生成波浪。 。