MAGNETIC RESONANCE ELASTOGRAPHY

磁共振弹性成像

• 批准号: 2896180
• 负责人: Richard L. Ehman
• 金额: $ 28.97万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-05 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896180
• 关键词: animal tissue; bioimaging /biomedical imaging; clinical research; diagnosis design /evaluation; elasticity; human subject; human tissue; image processing; magnetic resonance imaging; neoplasm /cancer diagnosis

It has long been known that malignant tumors are often characterized by substantially different mechanical properties than surrounding normal tissue. This accounts for the efficacy of palpation as a clinical technique to detect cancer in accessible regions of the body. Indeed, most tumors of the thyroid, breast, and prostate are still first detected by this centuries-old diagnostic technique. Unfortunately, small or inaccessible lesions cannot be detected by touch, and conventional diagnostic imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) do not provide information that is in any way analogous. The goal of this proposal is to develop and validate a diagnostic imaging technique for quantitatively delineating mechanical properties of tissues. The proposed technique applies mechanical waves to tissue and measures regional elasticity by analyzing the pattern of wave propagation. A critical component of this new technique is a recently-developed method for directly observing propagating acoustic waves in tissue, using an MRI sequence with synchronous motion-sensitizing gradients. The central hypothesis of this work is that the proposed technique can be successfully implemented as a clinical tool and that it will be useful for detecting and characterizing focal and diffuse disease processes that may be difficult to investigate by other methods. The research plan includes investigations in the following areas (I) improving the MR acoustic wave imaging sequence, (2) developing effective methods for applying acoustic waves to tissue, (3) refining the required image processing methods, (4) studying the potential of the technique for tissue characterization, and (5) implementing the technique in human studies. The methods will encompass theoretical work, basic MRI pulse sequence development, device engineering, studies of animal and human tissue specimens, and trials with normal and patient volunteer's, special emphasis on optimizing the technique for breast cancer detection. If the research is successful, it will yield a new diagnostic imaging tool that may: (I) provide a means to noninvasively "palpate by imaging" regions of the body that are beyond the reach of the physician's hand, (2) delineate tumors before they are large enough to detect by touch, (3) provide greater sensitivity for assessing changes in tissue elasticity, and (4) provide a useful new quantitative tool for characterizing tissue.

长期以来一直知道恶性肿瘤通常是特征的 与周围的机械性能实质上不同 正常组织。这说明了触诊的功效 检测到可访问区域的癌症的临床技术 身体。确实，甲状腺，乳房和前列腺的大多数肿瘤是 仍然被这种数百年历史的诊断技术检测到。 不幸的是，无法检测到小或无法及的病变 触摸和常规的诊断成像方法，例如 超声，计算机断层扫描（CT）和磁共振成像 （MRI）请勿以任何方式提供信息。 该建议的目的是开发和验证诊断 定量描绘机械的成像技术 组织的特性。提出的技术适用机械 通过分析，波浪向组织并测量区域弹性 波传播的模式。这个新的关键组成部分 技术是最近开发的直接观察方法 使用与 同步运动敏化梯度。中心假设 这项工作是提出的技术可以成功 作为临床工具实施，它将对 检测和表征局灶性和弥漫性疾病过程 这可能很难通过其他方法进行研究。 研究计划包括在以下领域进行调查（i） 改善MR声波成像序列，（2） 将声波应用于组织的有效方法，（3） 完善所需的图像处理方法，（4）研究 该技术的组织表征的潜力，（5） 在人类研究中实施该技术。方法将 包括理论工作，基本MRI脉冲序列发展， 设备工程，动物和人体组织标本的研究， 以及正常和患者志愿者的试验，特别强调 优化乳腺癌检测技术。 如果研究成功，它将产生新的诊断 可能的成像工具：（i）提供一种无创的手段 通过成像“身体的区域都无法触及 医师的手，（2）在足够大之前描绘肿瘤 通过触摸检测，（3）为评估提供了更大的灵敏度 组织弹性的变化，（4）提供了有用的新 用于表征组织的定量工具。