MAGNETIC RESONANCE ELASTOGRAPHY

磁共振弹性成像

• 批准号: 2896180
• 负责人: Richard L. Ehman
• 金额: $ 28.97万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-05 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2896180
• 关键词: animal tissue; bioimaging /biomedical imaging; clinical research; diagnosis design /evaluation; elasticity; human subject; human tissue; image processing; magnetic resonance imaging; neoplasm /cancer diagnosis

It has long been known that malignant tumors are often characterized by substantially different mechanical properties than surrounding normal tissue. This accounts for the efficacy of palpation as a clinical technique to detect cancer in accessible regions of the body. Indeed, most tumors of the thyroid, breast, and prostate are still first detected by this centuries-old diagnostic technique. Unfortunately, small or inaccessible lesions cannot be detected by touch, and conventional diagnostic imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) do not provide information that is in any way analogous. The goal of this proposal is to develop and validate a diagnostic imaging technique for quantitatively delineating mechanical properties of tissues. The proposed technique applies mechanical waves to tissue and measures regional elasticity by analyzing the pattern of wave propagation. A critical component of this new technique is a recently-developed method for directly observing propagating acoustic waves in tissue, using an MRI sequence with synchronous motion-sensitizing gradients. The central hypothesis of this work is that the proposed technique can be successfully implemented as a clinical tool and that it will be useful for detecting and characterizing focal and diffuse disease processes that may be difficult to investigate by other methods. The research plan includes investigations in the following areas (I) improving the MR acoustic wave imaging sequence, (2) developing effective methods for applying acoustic waves to tissue, (3) refining the required image processing methods, (4) studying the potential of the technique for tissue characterization, and (5) implementing the technique in human studies. The methods will encompass theoretical work, basic MRI pulse sequence development, device engineering, studies of animal and human tissue specimens, and trials with normal and patient volunteer's, special emphasis on optimizing the technique for breast cancer detection. If the research is successful, it will yield a new diagnostic imaging tool that may: (I) provide a means to noninvasively "palpate by imaging" regions of the body that are beyond the reach of the physician's hand, (2) delineate tumors before they are large enough to detect by touch, (3) provide greater sensitivity for assessing changes in tissue elasticity, and (4) provide a useful new quantitative tool for characterizing tissue.

众所周知，恶性肿瘤通常具有以下特征： 其机械性能与周围环境截然不同 正常组织。这解释了触诊作为一种方法的功效。 检测可及区域癌症的临床技术 身体。事实上，大多数甲状腺、乳腺和前列腺肿瘤都是 仍然是通过这种具有数百年历史的诊断技术首次检测到的。 不幸的是，小的或难以接近的病变无法通过 触摸和传统的诊断成像方法，例如 超声波、计算机断层扫描 (CT) 和磁共振成像 （MRI）不提供任何类似的信息。 该提案的目标是开发和验证诊断方法 定量描绘机械结构的成像技术 组织的特性。所提出的技术应用机械 波到组织并通过分析来测量区域弹性 波传播的模式。这个新产品的一个重要组成部分 技术是最近发展起来的直接观察方法 使用 MRI 序列在组织中传播声波 同步运动敏感梯度。中心假设为 这项工作是所提出的技术可以成功 作为一种临床工具实施，它将有助于 检测和表征局灶性和弥漫性疾病过程 通过其他方法可能很难调查。 研究计划包括以下几个方面的研究（一） 改进MR声波成像序列，（2）开发 将声波应用于组织的有效方法，(3) 细化所需的图像处理方法，（4）研究 该技术在组织表征方面的潜力，以及 (5) 在人类研究中实施该技术。这些方法将 包括理论工作、基本 MRI 脉冲序列开发、 设备工程、动物和人体组织标本的研究、 以及对正常和患者志愿者的试验，特别强调 优化乳腺癌检测技术。 如果研究成功，将产生新的诊断方法 成像工具可以：（I）提供一种非侵入性“触诊”的方法 通过对身体无法到达的区域进行成像” 医生的手，（2）在肿瘤足够大之前勾勒出肿瘤的轮廓 通过触摸检测，(3) 提供更高的评估灵敏度 组织弹性的变化，以及（4）提供了一种有用的新方法 用于表征组织的定量工具。