Magnetic Resonance Elastography

磁共振弹性成像

• 批准号: 7232384
• 负责人: Richard L. Ehman
• 金额: $ 33.52万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-05 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232384
• 关键词: Accounting; Acoustics; Animals; Area; Body Regions; Breast; Clinical; Data; Device or Instrument Development; Diagnostic Imaging; Diagnostic Procedure; Diffuse; Disease; Elasticity; Engineering; Goals; Hand; Image; Imaging Device; Imaging Techniques; Investigation; Lesion; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mechanics; Methods; Motion; Normal tissue morphology; Palpation; Patients; Pattern; Physicians; Physiologic pulse; Pilot Projects; Process; Property; Prostate; Pulse taking; Research; Specimen; Techniques; Tissues; Touch sensation; Ultrasonography; Work; X-Ray Computed Tomography; human tissue; improved; mathematical algorithm; new technology; thyroid neoplasm; tool; tumor; volunteer

DESCRIPTION (provided by applicant): It has long been known that malignant tumors are often characterized by substantially different mechanical properties than surrounding normal tissue. This accounts for the efficacy of palpation as a clinical technique to detect cancer in accessible regions of the body. Indeed, most tumors of the thyroid, breast, and prostate are still first detected by this centuries-old diagnostic technique. Unfortunately, small or inaccessible lesions cannot be detected by touch, and conventional diagnostic imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) do not provide information that is in any way analogous. The goal of this proposal is to continue to develop and validate a diagnostic imaging technique for quantitatively delineating mechanical properties of tissues. The technique applies mechanical waves to tissue and measures regional elasticity by analyzing the pattern of wave propagation. A critical component of this approach is sensitive MRI method for directly observing propagating acoustic waves in tissue, using an MRI sequence with synchronous motion-sensitizing gradients. The central hypothesis of this work is that the proposed technique can be successfully implemented as a practical scientific and clinical tool and that it will be useful for detecting and characterizing focal and diffuse disea.se processes that may be difficult to investigate by other methods. The research plan includes investigations in the following areas (1) improving the MR acoustic wave imaging technique, (2) developing effective methods for applying acoustic waves to tissue, (3) devising mathematical algorithms for processing the wave data, and (4) conducting pilot studies of selected applications of the new technology. The research plan in this continuation will again encompass theoretical work, basic MRI pulse sequence development, device engineering, studies of animal and human tissue specimens, and trials with normal and patient volunteers. Further progress is expected to provide an increasingly useful imaging tool with capabilities to: (1) noninvasively "palpate by imaging" regions of the body that are beyond the reach of the physician's hand, (2) delineate tumors before they are large enough to detect by touch, (3) provide greater sensitivity for assessing changes in tissue elasticity, and (4) provide a useful new quantitative scientific tool for characterizing tissue.

描述（由申请人提供）： 早就知道，恶性肿瘤通常具有与周围正常组织的机械特性大幅不同的特征。这说明了触诊作为一种临床技术的功效，以检测人体可及区域的癌症。实际上，这种数百年历史的诊断技术仍首先检测到甲状腺，乳腺癌和前列腺的大多数肿瘤。不幸的是，无法通过触摸检测到小或无法访问的病变，而常规的诊断成像方法，例如超声波，计算机断层扫描（CT）和磁共振成像（MRI）均未提供任何类似方式的信息。该提案的目的是继续开发和验证一种诊断成像技术，以定量描述组织的机械性能。该技术将机械波应用于组织，并通过分析波传播的模式来测量区域弹性。这种方法的一个关键组成部分是使用具有同步运动敏感梯度的MRI序列直接观察组织中传播波的敏感MRI方法。这项工作的核心假设是，所提出的技术可以成功实现为一种实用的科学和临床工具，并且对于检测和表征焦点和分散脉冲的过程将很有用。SE的过程可能难以通过其他方法研究。该研究计划包括在以下领域进行的研究（1）改进MR声波成像技术，（2）开发用于将声波应用于组织的有效方法，（3）设计用于处理波数据的数学算法，以及（4）导电对新技术的选定应用的试点研究。该延续中的研究计划将再次涵盖理论工作，基本MRI脉冲序列开发，设备工程，动物和人体组织标本的研究以及与正常和患者志愿者的试验。预计进一步的进展将提供越来越有用的成像工具，具有以下能力：（1）身体的“通过成像”区域无创的“触诊”，它超出了医生手的触手可及，（2）在足够大以检测到足以检测到的肿瘤之前。通过触摸，（3）为评估组织弹性的变化提供了更大的敏感性，（4）为表征组织提供了有用的新定量科学工具。