Multiparametric Tissue Characterization for Breast Cancer Screening Using Transmission and Reflection Ultrasound Tomography

使用透射和反射超声断层扫描进行乳腺癌筛查的多参数组织表征

• 批准号: 10675896
• 负责人: Rehman Ali
• 金额: $ 6.91万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675896
• 关键词: 3-Dimensional; Acoustics; Algorithms; Breast; Breast Cancer Detection; Breast Cancer Early Detection; Breast cancer metastasis; Callback; Cancer Detection; Detection; Disease; Early Diagnosis; Equation; Exposure to; FDA approved; Goals; Health Care Costs; Healthcare Systems; Image; Ionizing radiation; Knowledge; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Ultrasonography; Mammography; Measures; Methods; Modeling; Morphologic artifacts; Nonionizing Radiation; Patient Care; Patients; Performance; Physiologic pulse; Property; Radiation; Research; Resolution; Roentgen Rays; Screening for cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Speed; System; Techniques; Technology; Testing; Tissue Expansion; Tissue Model; Tissue imaging; Tissues; Translating; Ultrasonic wave; Ultrasonography; United States; Water; Woman; Work; World Health Organization; X-Ray Tomography; acoustic imaging; attenuation; bone; breast imaging; cancer biomarkers; cancer diagnosis; cost; density; diagnostic value; early detection biomarkers; imaging capabilities; imaging modality; improved; malignant breast neoplasm; migration; reconstruction; screening; sound; three-dimensional modeling; tomography; transmission process; ultrasound

PROJECT SUMMARY/ABSTRACT Breast cancer is the most diagnosed cancer in women in the United States and the most commonly occurring cancer worldwide according to the World Health Organization. The primary screening method for non-palpable breast cancers is X-ray mammography, which uses ionizing radiation and often has low sensitivity and specificity in dense breasts. Ultrasound tomography offers a low-cost alternative to X-ray mammography that can image the breast based on its acoustic properties and enable early cancer detection and diagnosis, while avoiding the potentially harmful effects of ionizing radiation. Currently, ultrasound tomography of the breast generally relies primarily on the transmission of ultrasound through the tissue to reconstruct underlying tissue properties such as sound speed and attenuation. However, a significant gap in our knowledge is the simultaneous modeling of signals transmitted through the tissue and signals reflected from the tissue to estimate these tissue properties. Combining transmission and reflection information from an ultrasound tomography system will enable accurate estimation of difficult-to-measure tissue properties such as the mass density. Furthermore, the addition of reflection information may enable tissue characterization in acoustically challenging cases where transmission information is less reliable (e.g., transmission through bone, partial angle tomography). I propose to improve the robustness of ultrasound transmission tomography by incorporating reflection information and enable the estimation of mass density. In order to expand the capabilities of the ultrasound tomography system I aim to: extend transmission tomography to three dimension in order account for out-of-plane scattering (Aim 1); develop algorithms to simultaneously reconstruct the sound speed, acoustic attenuation, and mass density of tissue using the complete transmission and reflection information acquired by an ultrasound tomography system (Aim 2); and develop sound speed reconstruction algorithms solely based on the reflected ultrasound signal, which will also benefit the applications of handheld pulse-echo ultrasound (Aim 3). These aims will improve our understanding of acoustic models applicable to ultrasound signals in both transmission and reflection as well as how these models may be inverted to reconstruct accurate and spatially resolved images of tissue properties. Expanding the tissue characterization capabilities of ultrasound tomography will enable a multi-parametric approach for the detection and characterization of breast cancer using a non-ionizing radiation imaging modality. Improving the robustness of ultrasound tomography in acoustically challenging cases will also enable cancer detection outside of the breast and may further enable detection of breast cancer metastasis. The proposed work will broadly benefit the ultrasound imaging field by improving our tissue modeling and characterization capabilities and enabling the early detection of disease based on acoustic tissue properties.

项目概要/摘要 乳腺癌是美国女性中诊断最多的癌症，也是最常见的癌症 根据世界卫生组织的数据，全球范围内都有癌症发生。初步筛选方法 不可触及的乳腺癌是 X 射线乳房X线照相术，它使用电离辐射，并且通常具有低 致密乳房的敏感性和特异性。超声波断层扫描提供了 X 射线的低成本替代方案 乳房X线照相术可以根据其声学特性对乳房进行成像并实现早期癌症检测 和诊断，同时避免电离辐射的潜在有害影响。目前，超声 乳房断层扫描通常主要依赖于超声波通过组织的传输 重建底层组织特性，例如声速和衰减。然而，存在显着差距 我们的知识是对通过组织传输的信号和反射的信号进行同步建模 从组织来估计这些组织特性。结合来自的传输和反射信息 超声断层扫描系统将能够准确估计难以测量的组织特性，例如 质量密度。此外，添加反射信息可以实现组织表征 声学上具有挑战性的情况，其中传输信息不太可靠（例如，通过骨骼传输， 部分角度断层扫描）。我建议提高超声透射断层扫描的鲁棒性 通过合并反射信息并能够估计质量密度。 为了扩展超声断层扫描系统的功能，我的目标是： 扩展传输 三维断层扫描，以考虑面外散射（目标 1）；开发算法 使用以下方法同时重建声速、声衰减和组织质量密度 超声断层扫描系统获取完整的透射和反射信息（目标2）；和 开发仅基于反射超声信号的声速重建算法，这也将 有利于手持式脉冲回波超声的应用（目标 3）。这些目标将增进我们的理解 适用于超声波信号传输和反射的声学模型以及这些模型如何 可以反转模型以重建组织特性的准确且空间分辨的图像。扩展 超声断层扫描的组织表征能力将使多参数方法成为可能 使用非电离辐射成像方式检测和表征乳腺癌。改善 超声断层扫描在声学上具有挑战性的情况下的稳健性也将有助于癌症检测 乳房外部，可以进一步检测乳腺癌转移。拟议的工作将 通过提高我们的组织建模和表征能力，使超声成像领域广泛受益 并能够根据声学组织特性实现疾病的早期检测。