Magnetic Resonance Elastography in Breast Cancer

乳腺癌的磁共振弹性成像

• 批准号: 6522702
• 负责人: Richard L. Ehman
• 金额: $ 29.49万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-08 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6522702
• 关键词: bioimaging /biomedical imaging; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; female; human subject; magnetic resonance imaging; noninvasive diagnosis; phantom model; women's health

DESCRIPTION (Provided by Applicant): Mortality from breast cancer is stage-dependent and thus, early detection is vital if we are to make progress addressing the burden of this disease. Imaging methods such as mammography have made a ma contribution in the early diagnosis of breast cancer. Yet is clear that the standard imaging techniques have significant limitations in detecting the earliest changes of breast cancer and in distinguishing benign condition from important premalignant and malignant disease. Based on the remarkable efficacy of simple palpation as a clinical tool for detecting cancer in accessible parts of the body, it has long been recognized that a sensitive, imaging-based method, capable of assessing viscoelastjc properties of tissue, might offer considerable potential for discriminating malignant from benign tissues. The goal of this research is to develop a practical noninvasive MRJ-based method for quantitatively evaluating the mechanical properties of breast tissues. We call this technique magnetic resonance elastography (MRE). Preliminary development of MRE in our laboratory has demonstrated the feasibility of quantitatively imaging the large differences in the elastic properties of normal and cancerous breast tissues in vivo. The specific aims of this proposal are (1) to further develop the MR elastography technology for pre imaging and (2) to assess the potential of this new imaging technique to differentiate breast malignancies fr non-malignant lesions. The MRE technique is implemented on a standard MRI scanner. Therefore it is readily combined in the same examination with standard contrast-enhanced MRI protocols for breast cancer imaging. This research-will provide the first substantial body of quantitative, spatially-resolved data describing the viscoelastic properties of benign and malignant breast tissues in vivo. The planned technical development work and pilot studies will provide critical prerequisites for determining the advisability and most efficient design of a future clinical trial to test the value of MRE for distinguishing benign from malignant breast masses.

描述（由申请人提供）：乳腺癌的死亡率是 依赖阶段，因此，如果我们要取得进步，早期检测至关重要 解决这种疾病的负担。乳房X线摄影等成像方法具有 在乳腺癌的早期诊断中做出了MA贡献。但是很清楚 标准成像技术在检测中具有重大局限性 乳腺癌最早的变化和区分良性状况 来自重要的预疾病和恶性疾病。 基于简单触诊作为临床工具的显着功效 在身体的可及部位检测癌症，长期以来已经认识到它 一种能够评估Viscoelastjc的敏感，基于成像的方法 组织的特性，可能会提供巨大的区分潜力 来自良性组织的恶性肿瘤。这项研究的目的是开发 实用无创的基于MRJ的方法，用于定量评估 乳房组织的机械性能。我们称这种技术磁性 共振弹性图（MRE）。 MRE在我们的实验室的初步发展 已经证明了定量成像大的可行性 正常乳腺组织和癌性乳腺组织弹性特性的差异 体内。 该提案的具体目的是（1）进一步发展MR 预先成像和（2）评估这一潜力的弹性技术 新成像技术可区分乳房恶性肿瘤。 病变。 MRE技术是在标准MRI扫描仪上实施的。因此 在同一检查中很容易与标准对比度增强的MRI合并 乳腺癌成像的方案。这项研究将提供第一个 大量的定量，空间分辨的数据描述了 体内良性和恶性乳腺组织的粘弹性。这 计划的技术发展工作和试点研究将提供关键 确定建议的可取性和最有效设计的先决条件 未来的临床试验，以测试MRE的良性和区分良性的价值 恶性乳房肿块。