Study on visualization of defect of internal elastic lamina of arterial wall for diagnosis of very early-stage atherosclerosis

动脉壁内弹力层缺损可视化诊断极早期动脉粥样硬化的研究

• 批准号: 23650298
• 负责人: KANAI Hiroshi
• 金额: $ 2.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650298/
• 关键词: 動脈硬化症; 医用超音波工学; 内弾性板欠損; 位相差トラッキング法; 表面粗さ推定; 位相差ﾄﾗｯｷﾝｸﾞ法; 非侵襲計測

It would be useful to measure the minute surface roughness of the carotid arterial wall to detect the endothelial damage in the early-stage of atherosclerosis. In conventional ultrasonography, the axial resolution of a B-mode image depends on the ultrasonic wavelength of 150 μm at 10 MHz. Therefore, the surface roughness caused by atherosclerosis in an early stage cannot be measured using a conventional B-mode image obtained by ultrasonography because the roughness is10-20 μm. We have realized accurate transcutaneous estimation of such a minute surface profile using the lateral motion of the carotid arterial wall, which is estimated by block matching of received ultrasonic signals. The proposed method was proved to be able to measure minute surface profile of about 10 μm by measuring a phantom, which had a saw tooth profile on its surface. Furthermore, the surface roughness of the carotid arterial walls of 10-50 μm were measured reproducibly for three healthy subjects (24-, 23-, and 23-year-old males).

测量颈动脉壁的微小表面粗糙度，以检测动脉粥样硬化的早期内皮损伤。在常规的超声检查中，B模式图像的轴向分辨率取决于10 MHz时150μm的超声波长度。因此，由于粗糙度为10-20μm，因此无法使用常规的B模式图像来测量早期动脉粥样硬化引起的表面粗糙度。我们已经使用颈动脉壁的侧向运动实现了对这种微小表面轮廓的准确估计，这是通过接收到的超声信号的块匹配来估算的。事实证明，所提出的方法能够通过测量幻影来测量约10μm的微小表面轮廓，该幻影在其表面上具有锯齿。此外，针对三个健康受试者（24岁，23岁和23岁的男性）重复测量了10-50μm的颈动脉壁的表面粗糙度。

项目成果

Noninvasive Measurement of Transient Change in Viscoelasticity Due to Flow-Mediated Dilation Using Automated Detection of Arterial Wall Boundaries

使用动脉壁边界自动检测无创测量血流介导扩张引起的粘弹性瞬态变化

• DOI: 10.1143/jjap.50.07hf08
• 发表时间: 2011
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: Kazuki Ikeshita;Hideyuki Hasegawa;and Hiroshi Kanai
• 通讯作者: and Hiroshi Kanai

Measurement of Displacement and Strain in Biological Tissue Generated by Ultrasound Dual Acoustic Radiation Force

超声双声辐射力产生的生物组织位移和应变的测量

• DOI: 10.1007/s10396-012-0372-9
• 发表时间: 2012
• 期刊: Journal of Medical Ultrasonics
• 影响因子: 1.8
• 作者: Jun Yamaguchi;Hideyuki Hasegawa;and Hiroshi Kanai
• 通讯作者: and Hiroshi Kanai

Minute Mechanical-Excitation Wave-Front Propagation in Human Myocardial Tissue

人体心肌组织中的微小机械激励波前传播

• 发表时间: 2011
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: Jun Yamaguchi;Hideyuki Hasegawa;and Hiroshi Kanai;Hiroshi Kanai and Motonao Tanaka
• 通讯作者: Hiroshi Kanai and Motonao Tanaka

Estimation of Radial Distribution of Ultrasound Scatterer Diameter for Assessment of Red Blood Cell Aggregation

超声散射直径径向分布的估计用于评估红细​​胞聚集

• 发表时间: 2012
• 作者: Nabilah Ibrahim;Hideyuki Hasegawa;and Hiroshi Kanai;高橋広樹，長谷川英之，金井 浩;小松洋介,長岡亮,太田信,船本健一,早瀬敏幸,金井浩,西條芳文;Nabilah Ibrahim，長谷川英之，金井 浩;Saijo Y.;森本拓朗，浪田健，加藤祐次，清水孝一;関 竜太郎，長谷川英之，金井 浩
• 通讯作者: 関 竜太郎，長谷川英之，金井 浩

内皮機能評価のための橈骨動脈壁粘弾性特性変化の高精度計測 Accurate Measurement of Transient Change in Viscoelasticity of Radial Arterial Wall for Evaluation of Endothelial Function

准确测量桡动脉壁粘弹性瞬态变化评价内皮功能

• 发表时间: 2011
• 作者: Horiguchi H;Yasunaga H;Hashimoto H;Ohe K.;池下和樹，長谷川英之，金井 浩
• 通讯作者: 池下和樹，長谷川英之，金井 浩