Research on diastolic properties of the myocardium by imaging propagation of shear wave along heart wall

剪切波沿心壁传播成像研究心肌舒张特性

• 批准号: 17206043
• 负责人: KANAI Hiroshi
• 金额: $ 32.45万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17206043/
• 关键词: Heart diseases; Medical ultrasonics; Myocardial elasticity; Phased tracking method; Noninvasive measurement; Tissue characterization; Myocardial viscosity; Lamb wave propagation; 動脈硬化症; 動脈壁弾性特性; 心臓壁粘性特性; 心臓疾患; 心臓壁弾性特性

By ultrasonic measurement of the myocardial motion, we have already found that pulsive waves are spontaneously excited by aortic-valve closure at end-systole. Since myocardial viscoelasticity is essential in the evaluation of heart diastolic properties, this study makes the physiological phenomenon to be measured noninvasively measured in vivo as follows:1 Using a sparse sector scan, the pulsive waves were measured almost simultaneously at several thousand points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions clearly revealed wave propagation along the heart wall. The phase velocity of the wave is determined for each frequency component. By comparing the dispersion of the phase velocity with the theoretical one of the Lamb wave, which propagates along the viscoelastic plate immersed in blood, the instantaneous viscoelasticity is determined noninvasively.2 We realized the principle of the measurement in a clinical ultrasonic diagn … More ostic system.3 By actuating a small pulse in an elastic spherical shell, which was made as a model of the heart, we confirmed that the viscoelasticity of the spherical shell can be measured with an error less than 10% of the viscoelasticity measured by the mechanical test.4 By applying the developed method to 5 healthy subjects, we confirmed the sufficient reproducibility of the propagation velocity of the pulsive wave among the consecutive cardiac cycles.5 We confirmed that the difference among the viscoelasticity values estimated from the 5 subjects is less than 20% and the transient of the viscoelasticity just after the aortic valve closure is similar. The viscoelasticity estimates are similar to those measured for the canine heart wall in literature.6 By applying the method to 10 patients with old myocardial infarction, we found that the amplitude and the propagation speed were decreased in each of the diseased areas. These results correspond to that obtained by using the longitudinal waves in literature.7 In conclusion, based on the new findings, we developed a means to measure the myocardial viscoelasticity in vivo. These clinical results indicate that the method has a potential for noninvasively revealing myocardial heterogeneity. Less

通过让Allydy发现脉冲波是通过主动脉瓣闭合在D-螺旋中自发激发的。在高级帧速率上，连续的相位分布清楚地揭示了沿着Hea Rt壁的波动，通过沿粘弹性板层延伸的每个频率分量确定了每种频率的波速度。在血液中，瞬时粘膜是非侵入性的。2我们意识到了测量仪超声乳头的原理……更多的骨质系统。3通过促进弹性球形，我们确认了弹性的弹性。可以用误差少于通过机械测试测量的误差的10％。4通过开发的方法，可以在5个健康受试者中使用脉冲波的传播速度足以确认，这证实了5个受试者之间的差异是在主动脉瓣关闭后，粘弹性少于20％，粘层是对文献中犬心脏壁测量的粘弹性。6在每个患病的EAS中，这些结果都与文献中的纵向波相对应。具有无创的心肌异质性

项目成果

Modification of the phased-tracking method for reduction of artifacts in estimated artery wall deformation

• DOI: 10.1109/tuffc.2006.145
• 发表时间: 2006-11-01
• 期刊: IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
• 影响因子: 3.6
• 作者: Hasegawa, Hideyuki;Kanai, Hiroshi
• 通讯作者: Kanai, Hiroshi

Improved Imaging of the Carotid Artery in the Short-axis Plane by a Mechanical Scanning Ultrasonic Probe

通过机械扫描超声探头改进颈动脉短轴平面成像

• 发表时间: 2007
• 期刊: Journal of Medical Ultrasonics 34
• 作者: R. Inada;Y. Nakamura;A. Oota,;Kazuki Kudo
• 通讯作者: Kazuki Kudo

Investigation of frequency characteristics in cutting of soft tissue using prototype ultrasonic knives

• DOI: 10.1143/jjap.46.4793
• 发表时间: 2007-07-01
• 期刊: JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS
• 作者: Ebina, Kosuke;Hasegawa, Hideyuki;Kanai, Hiroshi
• 通讯作者: Kanai, Hiroshi

Assessment of Vibration of the Myocardium

心肌振动的评估

• 发表时间: 2006
• 作者: S. Kidera;T. Sakamoto and T. Sato;Hiroshi Kanai
• 通讯作者: Hiroshi Kanai

A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes

• DOI: 10.1016/j.atherosclerosis.2006.11.020
• 发表时间: 2008-01-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Okimoto, Hisashi;Ishigaki, Yasushi;Oka, Yoshitomo
• 通讯作者: Oka, Yoshitomo