Research and Development of Medical Ultrasonic Equipment with Realtime Control of Ultrasonic Beam

超声束实时控制医用超声设备的研发

• 批准号: 10555134
• 负责人: KANAI Hiroshi
• 金额: $ 5.63万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10555134/
• 关键词: atherosclerosis; medical ultrasonics; elasticity; phased tracking; noninvasive measurement; tissue characterization; atheroma; bio-rheology; レオロジー

We have already developed a new method for accurately tracking the movement of the heart wall and arterial wall based on both the phase and magnitude of the demodulated signals to determine the instantaneous position of an object. In this research, a real-time system for measuring change in the thickness of the myocardium and the arterial wall is presented. In this system, an analytic signal from the standard ultrasonic diagnostic equipment is A/D converted at a sampling frequency of 1 MHz. By pipelining and parallel processing using four high-speed digital signal processing (DSP) chips, the above developed method is realized in real time. The tracking results for both sides of the heart/arterial wall are superimposed on the M (motion)-mode image in the work-station (WS) and the thickness changes of the heart/arterial wall are also displayed in real time. By this system, velocity signals, that is, the instantaneous movement of the heart/arterial wall with small amplitudes less than several micrometers on the motion resulting from a heartbeat with large amplitude of several millimeters, can be successfully detected in real time with sufficient reproducibility in the frequency range up 80Hz. From the regional change in thickness of the heart wall, spatial distribution of myocardial motility and contractility can be evaluated. For the arterial wall, its elasticity can be evaluated by referring to the blood pressure. In in vivo experiments, the rapid response of the change in wall thickness of the carotid artery to the dose of the nitroglycerine (NTG) is evaluated. This new real-time system offers potential for quantitative diagnosis of myocardial motility, early-stage atherosclerosis, and the transient evaluation of the rapid response of the cardiovascular system to physiological stress.

我们已经开发了一种新方法，可以根据解调信号的相位和大小来准确跟踪心脏壁和动脉壁的运动，以确定物体的瞬时位置。在这项研究中，提出了一种实时系统，用于测量心肌和动脉壁的厚度变化。在该系统中，来自标准超声诊断设备的分析信号的A/D为1 MHz的采样频率转换。通过使用四个高速数字信号处理（DSP）芯片进行管道和并行处理，上述方法是实时实现的。心脏/动脉壁两侧的跟踪结果叠加在工作站（运动）模式图像（WS）中，心脏/动脉壁的厚度变化也被实时显示。通过该系统，速度信号，即心脏/动脉壁的瞬时运动，其幅度小于小于几微米，这是由于心跳引起的，幅度很大，几毫米，可以实时成功地检测到足够的可重复性。在80Hz的频率范围内。从心脏壁厚度的区域变化中，可以评估心肌运动和收缩性的空间分布。对于动脉壁，可以通过参考血压来评估其弹性。在体内实验中，评估了颈动脉壁厚厚度对硝酸甘油（NTG）剂量的快速反应。这种新的实时系统为心肌运动，早期动脉粥样硬化以及心血管系统对生理压力的快速反应的瞬时评估提供了定量诊断的潜力。

项目成果

Hiroshi KANAI, Yoshiro KOIWA: "PARCORR-Based Time-Dependent AR Spectrum Estimation of Heart Wall Vibration"IEICE Transactions on Fundamental of Electronics, Communications and Computer Sciences. Vol. E82-A, No. 4. 572-579 (1999)

Hiroshi KANAI、Yoshiro KOIWA：“基于 PARCORR 的心壁振动的时间相关 AR 频谱估计”IEICE 电子、通信和计算机科学基础交易。

Hiroshi KANAI: "Spectrum Analysis of Sound and Vibration"Corona Publishing Co., Ltd.. 1-328 (1999)

Hiroshi KANAI：《声音和振动的频谱分析》Corona Publishing Co., Ltd.. 1-328 (1999)

H.Hasegawa,H.Kanai,N.Hoshimiya,N.Chubachi,and Y.Koiwa:"“Accuracy Evaluation in Measurement of a Small Change in the Thickness of Arterial Walls and the Measurement of Elasticity of the Human Carotid Artery,"" Japanese Journal of Applied Physics. 37・5B. 31

H.Hasekawa、H.Kanai、N.Hoshimiya、N.Chubachi 和 Y.Koiwa：“动脉壁厚度微小变化测量和人体颈动脉弹性测量的准确性评估”日本应用物理学杂志。37・5B。

中屋,金井,中鉢,本田,小岩: "超音波で計測した心臓壁微小振動の解析による左室拡張末期圧と心筋弾性値の非侵襲的計測"医用電子と生体工学. 37. 1-8 (1999)

Nakaya、Kanai、Cubachi、Honda、Koiwa：“通过分析超声测量的心壁微小振动来非侵入性测量左心室舒张末期压力和心肌弹性”《医疗电子与生物工程》37. 1-8 (1999)。 ）

Hiroshi KANAI, Yoshiro KOIWA, Yoshiko SAITO, Ikuk SUSUKIDA, and Motonao TANAKA: "In vivo Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls"Japanese Journal of Applied Physics. vol. 38, part 1, No. 5B. 3403-3408 (1999)

Hiroshi KANAI、Yoshiro KOIWA、Yoshiko SAITO、Ikuk SUSUKIDA 和 Motonao TANAKA：“小速度信号的体内测量和心壁厚度的变化”日本应用物理学杂志。