Research on Cross-Sectional Imaging of Elasticity around Atherosclerotic Plaque with Transcutaneous Ultrasound

经皮超声对动脉粥样硬化斑块周围弹性的断面成像研究

• 批准号: 10650400
• 负责人: KANAI Hiroshi
• 金额: $ 2.24万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650400/
• 关键词: atherosclerosis; medical ultrasonics; elasticity; phased tracking; noninvasive measurement; tissue characterization; atheroma; bio-rheology; 心筋症; リアルタイム計測; 心筋viability; 循環器系定量診断

The phased tracking method is unique in its extremely higher spatial and temporal resolution. This report shows the cross sectional image of the elasticity around the atherosclerotic plaque with this phase tracking method using transcutaneous ultrasound.The minimum value of the measurable velocity is 0.5 mm/s and the time interval, ΔT, of integration is 222 μs. In this condition, the lowest value of the change in thickness is found to be about 0.1μm in the measurements using a water tank. Such a minute change in thickness cannot be measured by CT, MRI, or standard ultrasonic diagnostic equipment.By presetting multiple points with equal intervals of 375 μm in the arterial wall at the R-wave of the ECG, and applying the above method to each point, the change in thickness in each layer between the succeeding points is determined. The change in thickness of each layer from that at the R-wave is then converted into color maps and displayed. By the proposed procedure described above, the elastic modulus E of the human carotid artery is noninvasively evaluated for the five layers along the ultrasonic beam.By modifying the method and system described above so that the elastic modulus of each local point in the arterial wall and the atherosclerotic plaque is determined by controlling the position of the ultrasonic beam. The results are then converted into another color map representing local elasticity in the cross sectional image. The regional elasticity is measured at each point along the ultrasonic beams at 30 positions along the axial direction of the artery. The resolution in the depth direction and axial direction is 375 μm and 0.98 mm, respectively. The atherosclerotic plaque has been characterized as the compliant material interior surrounded by much elastic material. With extrapolation of the results in an in vitro study, we interpreted the surrounding thin layer as the fibrous cap of the plaque.

分阶段跟踪方法在其极高的空间和临时分辨率方面是独一无二的。该报告显示，使用经皮超声使用此相跟踪方法，在动脉粥样硬化斑块周围弹性的横截面图像。可测量速度的最小值为0.5 mm/s，整合的时间间隔为ΔT，ΔT，ΔT，ΔT为222μs。在这种情况下，使用水箱的测量值发现，厚度变化的最低值约为0.1μm。这种微小的厚度变化无法通过CT，MRI或标准超声诊断设备来测量。通过在ECG的R波的动脉壁中预设多个点相等的间隔为375μm，并将上述方法应用于每个点，请确定每个点的厚度变化。然后将每一层的厚度变化从R波处的变化转换为彩色图并显示。通过上述提出的步骤，对沿超声梁的五层进行了颈动作的弹性模量e，通过修改上述方法和系统，以使伪影壁中每个局部点的弹性模量和动态斑块的弹性模量通过控制超声波束的位置来确定。然后将结果转换为另一个代表横截面图像中局部弹性的颜色图。沿着动脉的轴向方向在30个位置沿着超声波束在每个点测量区域弹性。深度方向和轴向方向的分辨率分别为375μm和0.98 mm。动脉粥样硬化斑块已被描述为围绕许多弹性物质的符合材料内部。随着结果的推断，在一项体外研究中，我们将周围的薄层解释为斑块的纤维帽。

项目成果

H.Kanai,他3名: "Accuracy Evaluation in Ultrasonic-based Measurement of Microscopic Change in Thick-ness"Electronics Letters. 35. 949-950 (1999)

H. Kanai 等人：“基于超声波的厚度微观变化测量的精度评估”《电子快报》35. 949-950 (1999)。

Hiroshi Kanai, and Yoshiro Koiwa: "PARCORR-based Time-Dependent AR Spectrum Estimation of Heart Wall Vibrations" IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. E82-A・4(印刷中). (1999)

Hiroshi Kanai 和 Yoshiro Koiwa：“基于 PARCORR 的心壁振动的时间相关 AR 频谱估计”IEICE 电子、通信和计算机科学基础知识汇刊 E82-A·4（出版中）。

Hiroshi KANAI, Shigemitsu NAKAYA, Hideyuki HONDA, and Yoshiro KOIWA: "Noninvasive Estimation of Left-Ventricular End-Diastole Elasticity by Analyzing Heart Wall Vibrations"Electronics Letters. Vol. 35, No. 10. 765-766 (1999)

Hiroshi KANAI、Shigemitsu NAKAYA、Hideyuki HONDA 和 Yoshiro KOIWA：“通过分析心壁振动对左心室舒张末期弹性进行无创估计”电子快报。

長谷川英之,金井 浩,星宮 望,中鉢憲賢,小岩喜郎: "動脈壁の厚み変化波形の周波数解析" 日本音響学会誌. 54・7. 473-481 (1998)

Hideyuki Hasekawa、Hiroshi Kanai、Nozomu Hoshimiya、Kenken Chubachi、Yoshiro Koiwa：“动脉壁厚度变化波形的频率分析”日本声学学会杂志 54・7（1998）。

H.Kanai, Y.Koiwa, Y.Saito, I.Susukida, and M.Tanaka: "In vivo Measurement of Small Velocity Signals and Change in Thickness of the Heart Walls" Japanese Journal of Applied Physics. 38・5B(印刷中). (1999)

H.Kanai、Y.Koiwa、Y.Saito、I.Susukida 和 M.Tanaka：“小速度信号的体内测量和心壁厚度的变化”日本应用物理学杂志 38・5B（出版中） ））（1999）。