Phase resolved ARF optical coherence elastography for intravascular imaging

用于血管内成像的相分辨 ARF 光学相干弹性成像

• 批准号: 10670744
• 负责人: ZHONGPING CHEN
• 金额: $ 75.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670744
• 关键词: Acoustics; Acute Coronary Event; Adipose tissue; Algorithms; American; Animal Disease Models; Animal Model; Arterial Fatty Streak; Arteries; Basic Science; Benchmarking; Biomechanics; Blood Vessels; Calibration; Cardiology; Cardiovascular Diseases; Cardiovascular system; Catheters; Cause of Death; Cessation of life; Characteristics; Chemicals; Clinical; Consultations; Development; Diagnosis; Disease Management; Disease Progression; Distal; Early Diagnosis; Elasticity; Evaluation; Funding; Histologic; Image; Imaging Techniques; Imaging technology; Lasers; Length; Lesion; Light; Maps; Measurement; Medical Device; Methods; Modality; Monitor; Morphologic artifacts; Morphology; Motion; Near-Infrared Spectroscopy; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Outcome; Pathogenesis; Pathologist; Penetration; Persons; Phase; Physicians; Procedures; Property; Protocols documentation; Radiation; Resolution; Risk; Roentgen Rays; Rupture; Safety; Scanning; Scheme; Source; Speed; Stress; System; Techniques; Technology; Therapeutic Intervention; Time; Tissues; Ultrasonics; Ultrasonography; United States; Validation; Visualization; Work; atherosclerotic plaque rupture; clinical translation; cost; design and construction; elastography; human error; imaging modality; imaging probe; imaging system; improved; in vivo; in vivo imaging; instrument; meter; multimodality; optical imaging; plaque lesion; porcine model; tool; ultrasound; Acoustics; Acute Coronary Event; Adipose tissue; Algorithms; American; Animal Disease Models; Animal Model; Arterial Fatty Streak; Arteries; Basic Science; Benchmarking; Biomechanics; Blood Vessels; Calibration; Cardiology; Cardiovascular Diseases; Cardiovascular system; Catheters; Cause of Death; Cessation of life; Characteristics; Chemicals; Clinical; Consultations; Development; Diagnosis; Disease Management; Disease Progression; Distal; Early Diagnosis; Elasticity; Evaluation; Funding; Histologic; Image; Imaging Techniques; Imaging technology; Lasers; Length; Lesion; Light; Maps; Measurement; Medical Device; Methods; Modality; Monitor; Morphologic artifacts; Morphology; Motion; Near-Infrared Spectroscopy; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Outcome; Pathogenesis; Pathologist; Penetration; Persons; Phase; Physicians; Procedures; Property; Protocols documentation; Radiation; Resolution; Risk; Roentgen Rays; Rupture; Safety; Scanning; Scheme; Source; Speed; Stress; System; Techniques; Technology; Therapeutic Intervention; Time; Tissues; Ultrasonics; Ultrasonography; United States; Validation; Visualization; Work; atherosclerotic plaque rupture; clinical translation; cost; design and construction; elastography; human error; imaging modality; imaging probe; imaging system; improved; in vivo; in vivo imaging; instrument; meter; multimodality; optical imaging; plaque lesion; porcine model; tool; ultrasound

PROJECT SUMMARY Cardiovascular disease is responsible for 1 in 4 deaths, or 650,000 Americans, every year. It is the leading cause of death in the United States. Ruptured atherosclerotic plaques are the main cause of acute coronary events, and it is of lethal consequence. Clinically, early detection of the latent vulnerability of plaques is the first line of defense against such deadly circumstances, and it relies on visualizing both tissue structural and biomechanical properties. Accurate characterization of a plaque lesion can facilitate better treatment management by further our understanding in the disease progression. The long-term objective of this proposal is to develop a multimodal intravascular imaging system that combines optical coherence tomography (OCT), ultrasound imaging (US), and shear-wave-based optical coherence elastography (OCESW) for studying and characterizing plaque vulnerability. The proposed system, IVOCT-US-OCESW, is built upon the ARF-OCE technology developed in the preceding proposal, with several significant technical advancements that will further facilitate its clinical translation. The proposed IVOCT-US- OCESW system unifies the high spatial resolution and extended penetration depth of the 1.7-µm OCT, the broad imaging depth of US, and the enhanced biomechanical contrast of OCESW. It will provide physicians a powerful clinical instrument for studying, diagnosing, and managing vulnerable plaques. The multimodal probe only requires a single disposable guide wire and catheter, thereby reducing the costs, procedure length, associated risks, and X-ray exposure. Our specific aims are to: 1) Design and construct a multimodal IVOCT-US-OCESW imaging probe; 2) Develop the IVOCT-US-OCESW system featuring a 4-MHz, 1.7-µm laser; 3) Establish a scanning protocol and algorithms for biomechanical property quantification; 4) Demonstrate the efficacy of the proposed system in normal and diseased animal models. We expect the development of the proposed high-speed, high-penetration-depth, and high-sensitivity IVOCT-US-OCESW system and probe to have significant impact to both basic science and clinical understanding of plaque pathogenesis. This will enhance the clinicians’ ability to identify vulnerable lesions, tailor interventional therapy, and monitor disease progression. More importantly, it will be a powerful tool that provides a quantitative means to benchmark and evaluate new medical devices and therapies.

项目摘要 每年，心血管疾病造成4分之一的死亡或65万美国人。是 美国的主要死亡原因。破裂的动脉粥样硬化斑块是急性的主要原因 冠状动脉事件，这是致命的后果。临床上，斑块的潜在脆弱性早期检测 是针对这种致命情况的第一道防线，它依赖于可视化两个组织结构 和生物力学特性。牙菌斑病变的准确表征可以促进更好的治疗 通过进一步理解疾病进展，管理。 该提议的长期目标是开发一种多模式的血管内成像系统 结合了光学相干断层扫描（OCT），超声成像（美国）和基于剪切波的光学 相干弹性图（OCESW）用于研究和表征斑块脆弱性。提出的系统， ivoct-us-ocesw，建立在上述建议中开发的ARF-OCE技术的基础上，有几个 重大的技术进步将进一步促进其临床翻译。提出的ivoct-us- OCESW系统统一了1.7 µm OCT的高空间分辨率和延长的穿透深度， 我们的成像深度以及OCESW的生物力学对比增强。它将为医生提供强大的 用于研究，诊断和管理脆弱斑块的临床工具。仅多模式探针 需要单个一次性导管和导管，从而降低成本，过程长度，相关 风险和X射线暴露。我们的具体目的是：1）设计和构建多模式IVOCT-US-OCESW 成像探针； 2）开发具有4 MHz，1.7 µm激光器的IVOCT-US-OCESW系统； 3）建立一个 用于生物力学性质定量的扫描协议和算法； 4）证明 在正常和解散的动物模型中提议的系统。 我们期望提出的高速，高渗透深度和高敏敏感的发展 IVOCT-US-OCESW系统和探测器对基础科学和临床理解都有重大影响 斑块发病机理。这将增强临床医生识别脆弱病变的能力，裁缝 治疗并监测疾病进展。更重要的是，它将是一个强大的工具，可以提供定量 意味着基准和评估新的医疗设备和疗法。