Combined OCT/US/PAT system for intravascular Imaging

用于血管内成像的组合 OCT/US/PAT 系统

基本信息

批准号：
8871465
负责人：
ZHONGPING CHEN
金额：
$ 67.77万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8871465
关键词：
Adopted Adverse effects Americas Animal Model Animals Area Arterial Fatty Streak Arteriogram Atherosclerosis Blood Vessels Blood coagulation Blood flow Brain Aneurysms California Cardiology Cardiovascular Diseases Carotid Arteries Catheters Cause of Death Cells Chemicals Cholesterol Clinical Collaborations Complication Coronary artery Developed Countries Development Diagnosis Disease Progression Early Diagnosis Engineering Exhibits Family suidae Fiber Grant Hospitals Image Imagery Imaging Device Imaging Techniques In Vitro Inflammatory Institutes Institution Lasers Lesion Lipids Modeling Molecular Molecular Structure Monitor Morbidity - disease rate Myocardial Infarction Nature Optical Coherence Tomography Oryctolagus cuniculus Pathology Patients Physician Executives Physicians Prevention Principal Investigator Procedures Progressive Disease Research Research Design Research Personnel Resolution Resources Rupture Scientist Speed Staging System Technical Expertise Technology Testing Thick Thrombus Time Tissues Transducers Translations Treatment Efficacy Ultrasonic Transducer Ultrasonography United States National Institutes of Health Universities Washington cardiovascular imaging cost density imaging system improved in vivo medical schools monocyte mortality multimodality nanosecond outcome forecast plaque lesion prevent prototype public health relevance signal processing success tomography tool

项目摘要

DESCRIPTION (provided by applicant): Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due to "vulnerable plaques" that rupture suddenly and trigger a blood clot or thrombus that blocks blood flow. Early detection of plaque lesions is the first and necessary step in preventing the lethal consequences of atherosclerosis. Diagnosis of the latent vulnerability of a plaque lesion relies on both tissue structural and chemical compositions. Multimodality intravascular imaging that can provide both structure and molecular information will provide clinicians with a critically important tool for diagnosing vulnerable plaques, monitoring the progression of disease, and evaluating the efficacy of intervention. The broad, long term objective of this proposal is to develop an integrated multimodal intravascular imaging system that combines intravascular ultrasound (IVUS), optical coherence tomography (OCT), and photoacoustic tomography (PAT). The multimodal intravascular imaging system is unique in that it combines the advantages of high spatial resolution of OCT, broad imaging depth of US, and molecular contrast of PAT. The integrated IVUS/OCT/PAT will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques. The specific aims are: (1) Develop a high-speed nanosecond fiber laser centered at 1730 nm for PAT imaging with lipid contrast; (2) Develop an integrated IVUS/OCT/PAT imaging catheter; (3) Develop a multimodality imaging system that combines IVUS/OCT/PAT; (4) Demonstrate real-time in vivo multimodality imaging of cardiovascular plaques in rabbit and porcine animal models. The proposed research requires an interdisciplinary team of scientists, engineers, and clinicians. We have assembled such a team: OCT/PAT group (Dr. Chen from BLI at UCI); IVUS/PAT group (Drs. Zhou and Shung from NIH Transducer Resource Center at USC); and Interventional cardiology group (Dr. Patel from Dept. of Cardiology at UCI). The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398

描述（由申请人提供）：动脉粥样硬化是一种进行性疾病，其特征在于动脉壁中脂质、胆固醇、纤维成分、单核细胞和各种其他炎症细胞的积累。动脉粥样硬化是发病和死亡的主要原因之一。发达国家心脏病（86%）和脑动脉瘤（45%）死亡的主要原因是“易损斑块”突然破裂。早期检测斑块病变是预防动脉粥样硬化致命后果的第一步，也是必要的一步。斑块病变潜在脆弱性的诊断依赖于组织结构和化学成分。可以提供结构和分子信息的血管内成像将为诊断易损斑块、监测疾病进展和评估干预效果提供极其重要的工具。该提案的广泛、长期目标是开发一种方法。集成多模态血管内成像系统，结合了血管内超声（IVUS）、光学相干断层扫描（OCT）和光声断层扫描（PAT）多模态血管内成像系统的独特之处在于它结合了OCT空间分辨率高、成像深度宽的优点。集成的 IVUS/OCT/PAT 将为医生提供强大的成像、诊断和易损斑块管理工具。（1）开发以1730 nm为中心的高速纳秒光纤激光器，用于脂质对比PAT成像；（3）开发集成IVUS/OCT/PAT成像导管；（3）开发结合IVUS/OCT/的多模态成像系统； PAT；（4）在兔子和猪动物模型中展示心血管斑块的实时体内多模态成像我们已经组建了一个由科学家、工程师和狂热分子组成的跨学科团队。团队：OCT/PAT 组（UCI BLI 的 Chen 博士）；IVUS/PAT 组（USC NIH 传感器资源中心的 Zhou 和 Shung 博士）；以及介入心脏病学组（UCI 心脏病学系的 Patel 博士）； ) ) 预计这项研究将对心血管疾病的早期检测、预防和治疗产生重大影响。