High-resolution Elastographic Assessment of the Optic Nerve Head

视神经乳头的高分辨率弹性成像评估

• 批准号: 10162604
• 负责人: ZHONGPING CHEN
• 金额: $ 65.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162604
• 关键词: Acoustics; Address; Affect; Age; Aging; American; Area; Bilateral; Biomechanics; Blindness; Cadaver; Chairperson; Characteristics; Clinical; Complex; Country; Crystallization; Data; Development; Disease; Elements; Eye; Gender; Generations; Glaucoma; Goals; Human; Image; Imaging Device; Institutes; Lasers; Measures; Modeling; Neurophysiology - biologic function; Optic Disk; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Pathogenesis; Patients; Performance; Phase; Physiologic Intraocular Pressure; Principal Investigator; Property; Race; Radiation; Research; Resolution; Resources; Risk Factors; Scientist; Stress; System; Systems Analysis; Techniques; Testing; Tissues; Transducers; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Vascular System; aging population; base; blind; clinical practice; disorder risk; elastography; imaging capabilities; imaging modality; in vivo imaging; in vivo imaging system; mechanical properties; nanometer resolution; novel; preclinical imaging; prototype; success; tool

Abstract Glaucoma is a leading cause of irreversible blindness worldwide, affecting over 2.2 million Americans. With an aging population, it is estimated that by 2020 the number of people suffering glaucoma will reach 80 million worldwide, with 11 bilaterally blind. The goal of this study is to develop a novel tool for imaging and measuring elastic properties of the optic nerve head (ONH) and lamina cribrosa (LC) non-invasively. To address this goal, we propose to use phase-resolved OCT to detect small displacements induced by acoustic radiation force (ARF) in the ONH. We further propose to build a novel single crystal 2D array operating in the 4~10 MHz range to generate the ARF pushing force. We propose to use single crystal ultrasound transducers for increased sensitivity. The combined system will enable us to generate images depicting local displacements with nanometer resolution. Using state-of-the-art numerical models this data will be integrated with the complex tissue macro and microstructure to determine the anisotropic, inhomogeneous elastic properties of the tissues of the ONH with high resolution and sensitivity. This will allow us to characterize in detail the association between age, race and gender on the mechanical properties of the tissues of the ONH. Our Specific Aims are: Specific Aim 1: Develop single crystal 2D ultrasound array for ARF pushing force generation. Specific Aim 2: Develop an integrated 2D array ARF-Optical coherence elastography (OCE) system that enables coregistered OCT, US, and ARF-OCE imaging. Specific Aim 3: Develop and validate numerical models that integrate the experimental data from Aims 1 and 2 to determine the local mechanical properties of the LC and ONH. Specific Aim 4: Conduct ex-vivo elastography of human cadaveric and rabbit eyes to establish the capability and assess the performance of the ARF-OCE system to detect changes in ONH and LC tissue properties associated with age, gender and species. In human eyes, we will also determine differences due to race or disease and between regions of the ONH. Specific Aim 5: Demonstrate preclinical imaging capability with in-vivo imaging of LC and ONH in rabbit eyes using ARF-OCE system and optimize system for in-vivo imaging.

抽象的 青光眼是全球不可逆失明的主要原因，影响了超过220万美国人。与 人口老龄化，据估计，到2020年，患有青光眼的人数将达到8000万 在全球，双侧盲。这项研究的目的是开发一种新颖的工具，用于成像和测量 视神经头（ONH）和lamina cribrosa（LC）的弹性特性非侵入性。为了解决这个目标， 我们建议使用相位分辨的OCT来检测声音辐射引起的小位移 （ARF）在Onh中。我们进一步建议在4〜10 MHz范围内构建一个新型的单晶2D阵列 产生ARF推力。我们建议使用单晶超声传感器增加 灵敏度。合并的系统将使我们能够生成图像，描绘了与 纳米分辨率。使用最新的数值模型，此数据将与复杂 组织宏和微观结构，以确定组织的各向异性，不均匀的弹性特性 具有高分辨率和灵敏度的ONH。这将使我们能够详细描述协会 在年龄，种族和性别之间在ONH组织的机械性能上。我们的具体目的是： 特定目标1：开发单晶2D超声阵列以产生ARF。 特定目的2：开发一个集成的2D阵列ARF光学相干弹性（OCE）系统，该系统该系统 启用核心的OCT，US和ARF-OCE成像。 特定目标3：开发和验证数值模型，这些模型整合了目标1和 2确定LC和ONH的局部机械性能。 特定目的4：进行人类尸体和兔子眼的前体内弹性弹力来建立能力 并评估ARF-OCE系统的性能检测ONH和LC组织特性的变化 与年龄，性别和物种有关。在人眼中，我们还将确定由于种族或 疾病以及ONH区域之间。 特定目标5：通过LC和ONH的体内成像在兔子眼中演示临床前成像能力 使用ARF-OCE系统并优化用于体内成像的系统。

项目成果

Ultrasonic Microelastography to Assess Biomechanical Properties of the Cornea.

• DOI: 10.1109/tbme.2018.2853571
• 发表时间: 2019-03
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Qian X;Ma T;Shih CC;Heur M;Zhang J;Shung KK;Varma R;Humayun MS;Zhou Q
• 通讯作者: Zhou Q

Transcranial Focused Ultrasound for Noninvasive Neuromodulation of the Visual Cortex.

• DOI: 10.1109/tuffc.2020.3005670
• 发表时间: 2021-01
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Lu G;Qian X;Castillo J;Li R;Jiang L;Lu H;Kirk Shung K;Humayun MS;Thomas BB;Zhou Q
• 通讯作者: Zhou Q

Ultrasound Retinal Stimulation: A Mini-Review of Recent Developments.

• DOI: 10.1109/tuffc.2022.3220568
• 发表时间: 2022-12
• 期刊: IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
• 影响因子: 3.6
• 作者: Lu, Gengxi;Qian, Xuejun;Gong, Chen;Ji, Jie;Thomas, Biju B.;Humayun, Mark S.;Zhou, Qifa
• 通讯作者: Zhou, Qifa

Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.

• DOI: 10.1016/j.ultras.2020.106263
• 发表时间: 2021-03
• 期刊: Ultrasonics
• 影响因子: 4.2
• 作者: Qian X;Li R;Lu G;Jiang L;Kang H;Kirk Shung K;Humayun MS;Zhou Q
• 通讯作者: Zhou Q

2-D Ultrasonic Array-Based Optical Coherence Elastography.

• DOI: 10.1109/tuffc.2020.3033304
• 发表时间: 2021-04
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Kang H;Qian X;Chen R;Wodnicki R;Sun Y;Li R;Li Y;Shung KK;Chen Z;Zhou Q
• 通讯作者: Zhou Q