High-resolution Elastographic Assessment of the Optic Nerve Head

视神经乳头的高分辨率弹性成像评估

基本信息

批准号：
10162604
负责人：
ZHONGPING CHEN
金额：
$ 65.64万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10162604
关键词：
Acoustics Address Affect Age Aging American Area Bilateral Biomechanics Blindness Cadaver Chairperson Characteristics Clinical Complex Country Crystallization Data Development Disease Elements Eye Gender Generations Glaucoma Goals Human Image Imaging Device Institutes Lasers Measures Modeling Neurophysiology - biologic function Optic Disk Optical Coherence Tomography Optics Oryctolagus cuniculus Pathogenesis Patients Performance Phase Physiologic Intraocular Pressure Principal Investigator Property Race Radiation Research Resolution Resources Risk Factors Scientist Stress System Systems Analysis Techniques Testing Tissues Transducers Ultrasonic Transducer Ultrasonography United States National Institutes of Health Vascular System aging population base blind clinical practice disorder risk elastography imaging capabilities imaging modality in vivo imaging in vivo imaging system mechanical properties nanometer resolution novel preclinical imaging prototype success tool

项目摘要

Abstract Glaucoma is a leading cause of irreversible blindness worldwide, affecting over 2.2 million Americans. With an aging population, it is estimated that by 2020 the number of people suffering glaucoma will reach 80 million worldwide, with 11 bilaterally blind. The goal of this study is to develop a novel tool for imaging and measuring elastic properties of the optic nerve head (ONH) and lamina cribrosa (LC) non-invasively. To address this goal, we propose to use phase-resolved OCT to detect small displacements induced by acoustic radiation force (ARF) in the ONH. We further propose to build a novel single crystal 2D array operating in the 4~10 MHz range to generate the ARF pushing force. We propose to use single crystal ultrasound transducers for increased sensitivity. The combined system will enable us to generate images depicting local displacements with nanometer resolution. Using state-of-the-art numerical models this data will be integrated with the complex tissue macro and microstructure to determine the anisotropic, inhomogeneous elastic properties of the tissues of the ONH with high resolution and sensitivity. This will allow us to characterize in detail the association between age, race and gender on the mechanical properties of the tissues of the ONH. Our Specific Aims are: Specific Aim 1: Develop single crystal 2D ultrasound array for ARF pushing force generation. Specific Aim 2: Develop an integrated 2D array ARF-Optical coherence elastography (OCE) system that enables coregistered OCT, US, and ARF-OCE imaging. Specific Aim 3: Develop and validate numerical models that integrate the experimental data from Aims 1 and 2 to determine the local mechanical properties of the LC and ONH. Specific Aim 4: Conduct ex-vivo elastography of human cadaveric and rabbit eyes to establish the capability and assess the performance of the ARF-OCE system to detect changes in ONH and LC tissue properties associated with age, gender and species. In human eyes, we will also determine differences due to race or disease and between regions of the ONH. Specific Aim 5: Demonstrate preclinical imaging capability with in-vivo imaging of LC and ONH in rabbit eyes using ARF-OCE system and optimize system for in-vivo imaging.

抽象的青光眼是全球不可逆转失明的主要原因，影响超过 220 万美国人。与一个人口老龄化，预计到2020年青光眼患者将达8000万全球范围内有 11 名双眼失明者。本研究的目标是开发一种用于成像和测量的新型工具无创地检测视神经乳头 (ONH) 和筛板 (LC) 的弹性。为了实现这一目标，我们建议使用相位分辨 OCT 来检测声辐射力引起的小位移（ARF）在ONH。我们进一步建议构建一种在 4~10 MHz 范围内运行的新型单晶二维阵列产生ARF推力。我们建议使用单晶超声换能器来增加敏感性。组合系统将使我们能够生成描述局部位移的图像纳米分辨率。使用最先进的数值模型，这些数据将与复杂的组织宏观和微观结构，以确定组织的各向异性、不均匀弹性特性具有高分辨率和灵敏度的 ONH。这将使我们能够详细描述该协会的特征年龄、种族和性别对 ONH 组织机械性能的影响。我们的具体目标是：具体目标 1：开发用于 ARF 推力产生的单晶二维超声阵列。具体目标 2：开发集成的 2D 阵列 ARF 光学相干弹性成像 (OCE) 系统支持配准 OCT、US 和 ARF-OCE 成像。具体目标 3：开发并验证整合目标 1 和目标 1 的实验数据的数值模型 2 确定LC和ONH的局部机械性能。具体目标 4：对人体尸体和兔眼进行离体弹性成像以建立能力并评估 ARF-OCE 系统检测 ONH 和 LC 组织特性变化的性能与年龄、性别和物种有关。在人眼中，我们也会确定由于种族或疾病和 ONH 区域之间。具体目标 5：通过兔眼体内 LC 和 ONH 成像来展示临床前成像能力使用ARF-OCE系统并优化体内成像系统。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ultrasonic Microelastography to Assess Biomechanical Properties of the Cornea.

DOI：
10.1109/tbme.2018.2853571
发表时间：
2019-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
0
作者：
Qian X;Ma T;Shih CC;Heur M;Zhang J;Shung KK;Varma R;Humayun MS;Zhou Q
通讯作者：
Zhou Q

Transcranial Focused Ultrasound for Noninvasive Neuromodulation of the Visual Cortex.

DOI：
10.1109/tuffc.2020.3005670
发表时间：
2021-01
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Lu G;Qian X;Castillo J;Li R;Jiang L;Lu H;Kirk Shung K;Humayun MS;Thomas BB;Zhou Q
通讯作者：
Zhou Q

Ultrasound Retinal Stimulation: A Mini-Review of Recent Developments.

DOI：
10.1109/tuffc.2022.3220568
发表时间：
2022-12
期刊：
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
影响因子：
3.6
作者：
Lu, Gengxi;Qian, Xuejun;Gong, Chen;Ji, Jie;Thomas, Biju B.;Humayun, Mark S.;Zhou, Qifa
通讯作者：
Zhou, Qifa

Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.