Combined OCT/US/PAT system for intravascular Imaging

用于血管内成像的组合 OCT/US/PAT 系统

• 批准号: 9042035
• 负责人: ZHONGPING CHEN
• 金额: $ 68.93万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9042035
• 关键词: Adopted; Adverse effects; Americas; Animal Model; Animals; Area; Arterial Fatty Streak; Arteriogram; Atherosclerosis; Blood Vessels; Blood coagulation; Blood flow; Brain Aneurysms; California; Cardiology; Cardiovascular Diseases; Carotid Arteries; Catheters; Cause of Death; Cells; Chemicals; Cholesterol; Clinical; Collaborations; Complication; Coronary artery; Developed Countries; Development; Diagnosis; Disease Progression; Early Diagnosis; Engineering; Exhibits; Family suidae; Fiber; Grant; Hospitals; Image; Imagery; Imaging Device; Imaging Techniques; In Vitro; Inflammatory; Institutes; Institution; Lasers; Lesion; Lipids; Modeling; Molecular; Molecular Structure; Monitor; Morbidity - disease rate; Myocardial Infarction; Nature; Optical Coherence Tomography; Oryctolagus cuniculus; Pathology; Patients; Physician Executives; Physicians; Prevention; Principal Investigator; Procedures; Progressive Disease; Research; Research Design; Research Personnel; Resolution; Resources; Rupture; Scientist; Speed; Staging; System; Technical Expertise; Technology; Testing; Thick; Thrombus; Time; Tissues; Transducers; Translations; Treatment Efficacy; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Universities; Washington; cardiovascular imaging; cost; density; imaging system; improved; in vivo; medical schools; monocyte; mortality; multimodality; nanosecond; outcome forecast; plaque lesion; prevent; prototype; public health relevance; signal processing; success; tomography; tool

 DESCRIPTION (provided by applicant): Atherosclerosis is a progressive disease that is characterized by the accumulation of lipids, cholesterol, fibrous constituents, monocytes, and various other inflammatory cells in the arterial wall. Atherosclerosis is one of the major causes of morbidity and mortality in developed countries. The major cause of deaths from heart attacks (86%) and brain aneurysm (45%) are due to "vulnerable plaques" that rupture suddenly and trigger a blood clot or thrombus that blocks blood flow. Early detection of plaque lesions is the first and necessary step in preventing the lethal consequences of atherosclerosis. Diagnosis of the latent vulnerability of a plaque lesion relies on both tissue structural and chemical compositions. Multimodality intravascular imaging that can provide both structure and molecular information will provide clinicians with a critically important tool for diagnosing vulnerable plaques, monitoring the progression of disease, and evaluating the efficacy of intervention. The broad, long term objective of this proposal is to develop an integrated multimodal intravascular imaging system that combines intravascular ultrasound (IVUS), optical coherence tomography (OCT), and photoacoustic tomography (PAT). The multimodal intravascular imaging system is unique in that it combines the advantages of high spatial resolution of OCT, broad imaging depth of US, and molecular contrast of PAT. The integrated IVUS/OCT/PAT will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques. The specific aims are: (1) Develop a high-speed nanosecond fiber laser centered at 1730 nm for PAT imaging with lipid contrast; (2) Develop an integrated IVUS/OCT/PAT imaging catheter; (3) Develop a multimodality imaging system that combines IVUS/OCT/PAT; (4) Demonstrate real-time in vivo multimodality imaging of cardiovascular plaques in rabbit and porcine animal models. The proposed research requires an interdisciplinary team of scientists, engineers, and clinicians. We have assembled such a team: OCT/PAT group (Dr. Chen from BLI at UCI); IVUS/PAT group (Drs. Zhou and Shung from NIH Transducer Resource Center at USC); and Interventional cardiology group (Dr. Patel from Dept. of Cardiology at UCI). The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398

 描述（由适用提供）：动脉粥样硬化是一种进行性疾病，其特征是脂质，胆固醇，纤维成分，单核细胞和其他各种炎症细胞在Art Wall中的积累。动脉粥样硬化是发达国家发病和死亡率的主要原因之一。心脏病发作（86％）和大脑动脉瘤（45％）导致死亡的主要原因是由于“脆弱的斑块”突然破裂并触发了阻塞血液流动的血凝块或血栓。早期发现牙菌斑病变是预防动脉粥样硬化的致命后果的第一步骤。斑块病变潜在脆弱性的诊断依赖于组织结构和化学成分。可以提供结构和分子信息的多模式性血管内成像，将为临床医生提供一种至关重要的易受损斑块的工具，监视该建议的广泛，长期的长期目标是开发一个集成的多模束内成像系统，该系统结合了脑内超声（IVUS），toctic coertorce（cot）和五十张。多模式的血管内成像系统是独一无二的，因为它结合了OCT高空间分辨率，广泛的成像深度和PAT的分子对比的优势。集成的IVUS/OCT/PAT将为实体人提供功能强大的工具，用于成像，诊断和管理脆弱的斑块。具体目的是：（1）开发一个以1730 nm为中心的高速纳米纤维激光器，用于与脂质对比度进行PAT成像； （2）开发一个集成的IVU/OCT/PAT成像导管； （3）开发一个组合IVUS/OCT/PAT的多模式成像系统； （4）展示了兔子和猪动物模型中心血管斑块的实时体内多模式成像。拟议的研究需要一个科学家，工程师和临床医生的跨学科团队。我们组建了这样的团队：OCT/PAT Group（UCI的Bli的Chen博士）； IVUS/PAT Group（USC的NIH Transducer资源中心的周博士和Shung博士）；和介入心脏病学小组（UCI心脏病学系的Patel博士）。拟议的研究预计将对心血管疾病的早期发现，预防和治疗产生重大影响。 PHS 398