Simultanous Measurement of Velocity Signals at Multiple Points in the Heart Wall for Noninvasive Evaluation of Left Ventricular Inner Pressure and Elastic Modulus

同时测量心壁多点速度信号，无创评估左心室压力和弹性模量

• 批准号: 12650416
• 负责人: KANAI Hiroshi
• 金额: $ 2.62万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650416/
• 关键词: heart diseases; Medical ultrasonics; eigenvibration; phased tracking method; noninvasive measurement; tissue characterization; left ventricular inner pressure; vibration measurement

Myocardial motion exhibits frequency components of up to 100 Hertz as found by a phased tracking method. To simultaneously measure the rapid and minute velocity signals at multiple points along the surface of the left ventricle (LV), in this study, conventional ultrasonic diagnosis equipment was modified to allow 10 scan lines from a sector scanner to be arbitrarily selected in real time for analysis. By considering the maximum value of the velocity in the heart wall and the maximum depth from the chest surface, the number of transmission directions of the ultrasonic pulses should be carefully confirmed to be 10 to avoid aliasing, which is much less than the number employed in conventional tissue Doppler imaging (TDI). By applying the system, the velocity signals at about 240 points in the heart walls were simultaneously measured for three healthy volunteers. During a short period of 35 ms around end-diastole, the velocity signals varied spatially in the heart wall. At the end of systo … More le, in the wavelets near the base of the interventricular septum (IVS), the slow pulse continued for about 30 ms just before the radiation timing of the second heart sound. Then, a steep pulse occurred just at the timing of the closure of the aortic valve. The steep pulse at the base preceded that at the apex by several milliseconds. By Fourier transforming each wavelet, the spatial distribution of the phase of the steep pulsive components were clearly displayed. By applying the measurement method to two patients with aortic stenosis (AS) , irregular vibration signals, which correspond to the murmur of the heart sound, could be directly detected during ejection period. In conventional TDI, only the large slow movements due to the heartbeat are displayed, while these rapid and minute velocity components cannot be displayed. In this study, moreover, the phase components were detected for the first time from each of the velocity signals simultaneously measured at multiple points along the 10 scan lines. This measurement and method of analysis offer potential for new diagnostic techniques in cardiac dysfunction. Less

通过分阶段跟踪方法发现，心肌运动表现出高达100赫兹的频率成分。为了同时测量沿左通气表面（LV）的多个点处的快速和微小速度信号，在这项研究中，修改了常规的超声波诊断设备，以实时从扇区扫描仪中进行10次扫描线，以实时选择。通过考虑心脏壁中速度的最大值和胸表面的最大深度，应仔细确认超声波脉冲的传输方向的数量为10，以避免混音，这远小于常规组织多普勒成像（TDI）中使用的数量。通过应用系统，简单地为三名健康志愿者测量了心脏壁中约240点的速度信号。在末端末端末端的短时间35毫秒内，速度信号在心脏壁上在空间上变化。在Systo的末尾……更多的LE，在室内隔膜底部附近的小波中（IVS），在第二心脏声音的辐射时机之前，缓慢的脉冲持续了约30毫秒。然后，在主动脉瓣关闭的时机上发生了钢脉冲。底座的钢脉冲在顶点处的几毫秒。通过傅立叶变换每个小波，清楚地显示了钢脉冲分量相位的空间分布。通过将测量方法应用于两名正向狭窄（AS）的患者，可以在弹出期间直接检测到与心脏声音的杂音相对应的不规则振动信号。在常规的TDI中，仅显示由于心跳而引起的较大慢速运动，而这些快速和微小的速度组件无法显示。此外，在这项研究中，第一次从每个速度信号沿着10个扫描线以多个点测量的每个速度信号首次检测到相分量。这种测量和分析方法为心脏功能障碍中新的诊断技术提供了潜力。较少的

项目成果

H.Hasegawa, H.Kanai, Y.Koiwa: "Modified Phased Tracking Method for Measurement of Change in Thickness of Arterial Wall"Japanese Journal of Applied Physics. 41(印刷中). (2002)

H.Hasekawa、H.Kanai、Y.Koiwa：“用于测量动脉壁厚度变化的改进的阶段性跟踪方法”，日本应用物理学杂志 41（出版中）。

M.Watanabe,H.Kanai: "Optimization of Focal Position of Ultrasonic Beam in Measurement of Small Change in Thickness of Arterial Wall"Japanese Journal of Applied Physics. 40(印刷中). (2001)

M. Watanabe、H. Kanai：“动脉壁厚度微小变化测量中超声波束焦点位置的优化”，《日本应用物理学杂志》40（出版中）。

H.Kanai, Y.Koiwa: "Myocardial Rapid Velocity Distribution"Ultrasound in Medicine and Biology. 27. 481-498 (2001)

H.Kanai，Y.Koiwa：医学和生物学中的“心肌快速速度分布”超声。

Masaru Watanabe, Hiroshi Kanai: ""Optimization of Focal Position of Ultrasonic Beam in Measurement of Small Change in Arterial Wall Thickness,""Japanese Journal of Applied Physics. Vol. 40, Part1, No. 5B. 3918-3921

Masaru Watanabe、Hiroshi Kanai：“动脉壁厚度微小变化测量中超声波束焦点位置的优化”，《日本应用物理学杂志》。

小林,金井,大橋,鈴木: "音・振動による診断工学"コロナ社. 202 (2000)

Kobayashi、Kanai、Ohashi、Suzuki：“使用声音和振动的诊断工程”Coronasha 202 (2000)。