An Investigation on Noninvasive Measurement of Transmural Distribution of Myocardial Systolic Function and Diastolic Properties Using Ultrasound

超声无创测量心肌收缩功能和舒张功能透壁分布的研究

• 批准号: 15300177
• 负责人: KANAI Hiroshi
• 金额: $ 10.62万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15300177/
• 关键词: Ultrasonic Doppler method; Local change in thickness; Myocardial contraction; relaxation; Myocardial motility; Spectrum analysis; Color-coded display; Tissue Characterization; phased tracking method; 医用超音波工学; 心臓壁弾性特性; 非侵襲計測; 組織性状診断; 心臓壁粘性特性 /

For the serious heart diseases, the different transmural layers of the myocardium have transmural heterogeneity with respect to the strength of contraction. A method for measuring such transmural heterogeneity with sufficient spatial resolution has never been developed. In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. Moreover, a novel method for measuring the myocardial viscoelasticity was developed and its principle was confirmed by the basic experiments and in vivo experiments as follows :1.In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed.2.Based on the basic experiments using a spherical shell made of silicone rubber, which physical parame … More ters are known, as a heart-mimicking phantom, the accuracy of the measurement of the developed method was confirmed.3.Moreover, this study developed the following novel method for noninvasively measuring the myocardial viscoelasticity at the beginning of diastole and for imaging the transmural heterogeneity in the propagation of the elastic waves. The method was applied to healthy subjects and patients with heart diseases. By this method, a velocity signal of the heart wall can be successfully detected with sufficient reproducibility. In this study, the pulsive waves were measured almost simultaneously at about 160 points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions, obtained by the Fourier transform of the measured waves, clearly revealed wave propagation along the heart wall for the first time. Based on this phenomenon, we developed a means to measure the myocardial viscoelasticity in vivo using the model of the Lamb wave propagation in a viscoelastic plate. This method has a potential to noninvasively evaluate the myocardial viscoelasticity. Less

对于心脏内收缩/放松的异质性，厚度的厚度速度的变化及其测量方法是开发了一种新颖的方法，并开发了一种测量粘膜的新方法在体内实验如下：1。在这项研究中，开发了一种测量心脏内收缩/松弛厚度或在二维ATS测量系统中的速度的方法。2。基于使用由硅胶橡胶制成的基本实验基于基本实验，哪个物理参数...被称为心动幻象方法的更多ters。在弹性波的传播中。沿着充分的H帧速率沿着心脏壁。此方法有可能评估Myocoelastics

项目成果

K.Michishita, H.Hasegawa, H.Kanai: "Ultrasonic Measurement of Minute Displacement of Object Cyclically Actuated by Acoustic Radiation Force"Japanese Journal of Applied Physics. 42. 4608-4612 (2003)

K.Michishita、H.Hasekawa、H.Kanai：“声辐射力循环驱动物体微小位移的超声波测量”日本应用物理学杂志。

H.Kanai, Y.Koiwa, S.Katsumata, N.Izumi, M.Tanaka: "Measurement of rapid variation in ultrasound backscattering during change in thickness of tissue phantom"Japanese Journal of Applied Physics. 42. 3239-3245 (2003)

H.Kanai、Y.Koiwa、S.Katsumata、N.Izumi、M.Tanaka：“组织模型厚度变化期间超声反向散射快速变化的测量”日本应用物理学杂志。

超音波を用いた対象物の局所ひずみ発生装置

使用超声波的物体局部应变发生器

• 发表时间: 2004

H.Kanai, H.Hasegawa, M.Ichiki, F.Tezuka, Y.Koiwa: "Elasticity Imaging of Atheroma with Transcutaneous Ultrasound -Preliminary Study-"Circulation. 107. 3018-3021 (2003)

H.Kanai、H.Hasekawa、M.Ichiki、F.Tezuka、Y.Koiwa：“经皮超声对动脉粥样硬化的弹性成像 - 初步研究 -”循环。

International Congress Series State of the Art : Ultrasonics in Medicine

国际大会系列最新技术：超声医学

• 发表时间: 2004
• 作者: Hiroshi Kanai;Hideyuki Hasegawa;Nozomi Nakagawa
• 通讯作者: Nozomi Nakagawa