An Investigation on Noninvasive Measurement of Transmural Distribution of Myocardial Systolic Function and Diastolic Properties Using Ultrasound

超声无创测量心肌收缩功能和舒张功能透壁分布的研究

• 批准号: 15300177
• 负责人: KANAI Hiroshi
• 金额: $ 10.62万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15300177/
• 关键词: Ultrasonic Doppler method; Local change in thickness; Myocardial contraction; relaxation; Myocardial motility; Spectrum analysis; Color-coded display; Tissue Characterization; phased tracking method; 医用超音波工学; 心臓壁弾性特性; 非侵襲計測; 組織性状診断; 心臓壁粘性特性 /

For the serious heart diseases, the different transmural layers of the myocardium have transmural heterogeneity with respect to the strength of contraction. A method for measuring such transmural heterogeneity with sufficient spatial resolution has never been developed. In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. Moreover, a novel method for measuring the myocardial viscoelasticity was developed and its principle was confirmed by the basic experiments and in vivo experiments as follows :1.In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed.2.Based on the basic experiments using a spherical shell made of silicone rubber, which physical parame … More ters are known, as a heart-mimicking phantom, the accuracy of the measurement of the developed method was confirmed.3.Moreover, this study developed the following novel method for noninvasively measuring the myocardial viscoelasticity at the beginning of diastole and for imaging the transmural heterogeneity in the propagation of the elastic waves. The method was applied to healthy subjects and patients with heart diseases. By this method, a velocity signal of the heart wall can be successfully detected with sufficient reproducibility. In this study, the pulsive waves were measured almost simultaneously at about 160 points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions, obtained by the Fourier transform of the measured waves, clearly revealed wave propagation along the heart wall for the first time. Based on this phenomenon, we developed a means to measure the myocardial viscoelasticity in vivo using the model of the Lamb wave propagation in a viscoelastic plate. This method has a potential to noninvasively evaluate the myocardial viscoelasticity. Less

对于严重的心脏病，心肌的不同透明层相对于收缩强度具有变革性异质性。从未开发出一种用足够的空间分辨率测量这种变革性异质性的方法。在这项研究中，通过评估厚度的变化或速度的变化及其测量系统，通过评估厚度的变化或速度的变化来无创测量的方法。此外，开发了一种测量心肌粘弹性的新方法，并通过基本实验和体内实验证实了它的原理，如下所示：1。在这项研究中，一种无创测量的方法，用于对基本厚度或在厚度上的变化来评估其在厚度上的变化。确认了由硅胶橡胶制成的球形壳，该材料的物理材料……更多的ters被称为令人心碎的幻影，确认了开发方法的测量的准确性。3。此外，此外，这项研究开发了以下新颖的方法，用于在糖尿病的开始时对心肌粘附性进行非侵袭性测量，以实现杂物性的弹性效应，以实现跨度的黑质率。该方法应用于健康的受试者和心脏病患者。通过这种方法，可以通过足够的可重复性成功检测到心脏壁的速度信号。在这项研究中，以足够高的框架速率同时测量脉冲波几乎同时测量的160点。通过测量波的傅立叶变换获得的连续空间相分布，首次沿着心脏壁清楚地揭示了波的传播。基于这种现象，我们开发了一种使用粘弹板中羔羊波传播的模型在体内测量心肌粘弹性的方法。该方法具有非侵入性评估心肌粘弹性的潜力。较少的

项目成果

K.Michishita, H.Hasegawa, H.Kanai: "Ultrasonic Measurement of Minute Displacement of Object Cyclically Actuated by Acoustic Radiation Force"Japanese Journal of Applied Physics. 42. 4608-4612 (2003)

K.Michishita、H.Hasekawa、H.Kanai：“声辐射力循环驱动物体微小位移的超声波测量”日本应用物理学杂志。

H.Kanai, Y.Koiwa, S.Katsumata, N.Izumi, M.Tanaka: "Measurement of rapid variation in ultrasound backscattering during change in thickness of tissue phantom"Japanese Journal of Applied Physics. 42. 3239-3245 (2003)

H.Kanai、Y.Koiwa、S.Katsumata、N.Izumi、M.Tanaka：“组织模型厚度变化期间超声反向散射快速变化的测量”日本应用物理学杂志。

超音波を用いた対象物の局所ひずみ発生装置

使用超声波的物体局部应变发生器

• 发表时间: 2004

H.Kanai, H.Hasegawa, M.Ichiki, F.Tezuka, Y.Koiwa: "Elasticity Imaging of Atheroma with Transcutaneous Ultrasound -Preliminary Study-"Circulation. 107. 3018-3021 (2003)

H.Kanai、H.Hasekawa、M.Ichiki、F.Tezuka、Y.Koiwa：“经皮超声对动脉粥样硬化的弹性成像 - 初步研究 -”循环。

International Congress Series State of the Art : Ultrasonics in Medicine

国际大会系列最新技术：超声医学

• 发表时间: 2004
• 作者: Hiroshi Kanai;Hideyuki Hasegawa;Nozomi Nakagawa
• 通讯作者: Nozomi Nakagawa