Microbial Iron Acquisition: Investigations of Amphiphilic Siderophores

微生物铁的获取：两亲性铁载体的研究

基本信息

批准号：
1059067
负责人：
Alison Butler
金额：
$ 44.76万
依托单位：
University of California-Santa Barbara
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至 2015-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1059067&HistoricalAwards=false
关键词：
Microbial Iron Acquisition Investigations Amphiphilic

项目摘要

This award in the Chemistry of Life Processes (CLP) program supports work by Professor Alison Butler at the University of California, Santa Barbara to carry out fundamental studies on the process of iron acquisition by bacteria that is mediated by siderophores. Nearly all bacteria require iron to grow. Siderophores are low molecular mass chelating ligands produced by bacteria that coordinate Fe(III) with very high affinity and facilitate iron uptake by the bacterium. Marine bacteria often produce suites of amphiphilic siderophores that vary in the nature of the fatty acid tail. The interactions of the amphiphilic siderophores, their self-assembled structures and the bacteria will be probed to investigate whether the amphiphilic character of these siderophores confers a distinct molecular advantage for microbial iron acquisition.This project supports the education and training of graduate and undergraduate students in a highly interdisciplinary research project in a manner that will serve to broaden and deepen the level of research training. Some marine bacteria grow on petroleum hydrocarbons as their sole source of carbon and energy; yet before bacteria can begin to oxidize hydrocarbons, they must first acquire iron for growth and then for assimilation into the key enzymes. Thus understanding how oil-degrading bacteria acquire the essential nutrient, iron, would benefit efforts to enhance microbial hydrocarbon oxidation of environmental concern.

该奖项在《生命过程》（CLP）计划（CLP）计划中支持加利福尼亚大学圣塔芭芭拉分校的艾莉森·巴特勒教授的工作，以对由Siderophores介导的细菌进行铁的进程进行基础研究。几乎所有细菌都需要铁生长。铁载体是由细菌产生的低分子质量螯合配体，该配体与非常高的亲和力配合Fe（III），并促进细菌的铁吸收。海洋细菌通常会产生两亲性铁载体的套件，在脂肪酸尾巴的性质上有所不同。两亲性铁载体的相互作用，它们的自组装结构和细菌将被探测，以调查这些铁载体的两亲性特征是否赋予了微生物习得的独特分子优势。该项目支持研究和培训研究生和培训的研究生和培训。一个高度的跨学科研究项目，该项目将扩大和加深研究培训水平。一些海洋细菌在石油烃上生长，作为其唯一的碳和能源来源。然而，在细菌可以开始氧化碳氢化合物之前，它们必须首先获得铁以生长，然后将其同化为关键酶。因此，了解降解细菌如何获得必需的营养素铁将有益于增强微生物碳氢化合物氧化环境关注的努力。