Trace element levels and risk of stroke

微量元素水平与中风风险

• 批准号: 8665933
• 负责人: Ka Kahe
• 金额: $ 51.06万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-17 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665933
• 关键词: Adult; African American; Air Pollution; Alabama; Area; Arkansas; Arsenic; Atherosclerosis; Attention; Biological; Cadmium; Cardiovascular Diseases; Caucasians; Caucasoid Race; Centers for Disease Control and Prevention (U.S.); Characteristics; Child; China; Chronic Disease; Code; Cohort Studies; Communities; Congestive; Country; Data; Development; Diet; Disease; Economics; Elements; Environmental Risk Factor; Epidemiology; General Population; Geographic Locations; Health; Health care facility; Healthcare; Human; Hypertension; Incidence; Individual; Infection; Inflammation; Ischemic Stroke; Length; Life; Life Style; Lipids; Literature; Louisiana; Magnesium; Maps; Measures; Mercury; Minor; Mississippi; Modification; North Carolina; Nutritional; Participant; Pattern; Peripheral Vascular Diseases; Persons; Physiological Processes; Play; Poverty; Race; Reasons for Geographic And Racial Differences in Stroke; Regulation; Research; Research Personnel; Risk; Role; Rural; Sampling; Selenium; Serum; Sex Characteristics; Smoking; Soil; South Carolina; Specimen; Stroke; Taiwan; Tennessee; Testing; Trace Elements; United States National Aeronautics and Space Administration; Urine; Vascular Diseases; Water; aged; base; blood pressure regulation; cofactor; cohort; density; environmental intervention; geographic difference; lifestyle intervention; low socioeconomic status; mortality; population based; prospective; racial difference; repository; residence; selenium deficiency; sex; social; study characteristics

DESCRIPTION (provided by applicant): Despite minor geographic shifts, the "Stroke Belt", a region of highest stroke mortality in the Southeastern US identified a half century ago, still persists today. Recent studies have found that the stroke mortality is also higher among children in the Southeast, thus environmental factors have been hypothesized contributing to the "Stroke Belt" in addition to other hypotheses on lifestyle and social-economic status. For decades, it has been demonstrated outside the US that geographic variations in trace elements may play critical roles in the development of cardiovascular diseases. However, the geographic variation of trace element levels in relation to stroke risk remains unclear. The overall objectives of this project ae to examine the associations between trace element levels and stroke risk and to investigate whether geographic variation of trace element levels is related to the "Stroke Belt". We propose a case-cohort study, which will include incident ischemic stroke cases (n=~620) and a sub-cohort (n=~2500) of non-stroke cases randomly sampled within region-race-sex stratum from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, an ongoing US national population-based, general population cohort of 30,239 African American and Caucasian adults, aged 45 and older at baseline (2003-2007). The proposed study will focus on arsenic, cadmium, mercury, magnesium and selenium. Specifically, we will characterize the distribution of trace element levels measured in urine or serum according to demographic and geographic characteristics of study participants; and to examine prospective associations between trace element levels and risk of stroke. This research will help identify at-risk individuals for stroke, thus providing important data identifying whether stroke risk can be reduced by dietary, supplemental, lifestyle or environmental interventions that modify trace element patterns.

描述（由申请人提供）：尽管地理上发生了微小的变化，半个世纪前确定的美国东南部中风死亡率最高的“中风带”今天仍然存在。最近的研究发现，东南部儿童的中风死亡率也较高，因此除了生活方式和社会经济地位的其他假设外，还假设环境因素导致“中风带”。几十年来，在美国以外的地区已经证明，微量元素的地理差异可能在心血管疾病的发展中发挥关键作用。然而，与中风风险相关的微量元素水平的地理差异仍不清楚。该项目的总体目标是检查微量元素水平与中风风险之间的关联，并调查微量元素水平的地理变化是否与“中风带”相关。我们提出了一项病例队列研究，其中包括缺血性卒中病例（n=~620）和非卒中病例亚队列（n=~2500），这些病例是在区域-种族-性别阶层中随机抽取的，原因如下：中风的地理和种族差异 (REGARDS) 研究是一项正在进行的美国全国人口一般人群队列，共有 30,239 名 45 岁的非裔美国人和白种人成年人和基线年龄（2003-2007 年）。拟议的研究将重点关注砷、镉、汞、镁和硒。具体来说，我们将根据研究参与者的人口和地理特征来描述尿液或血清中测得的微量元素水平的分布；并检查微量元素水平与中风风险之间的前瞻性关联。这项研究将有助于识别中风风险个体，从而提供重要数据，以确定是否可以通过改变微量元素模式的饮食、补充剂、生活方式或环境干预措施来降低中风风险。