Trace mineral levels, the trajectory of cognitive decline and telomere attrition

微量矿物质水平、认知能力下降和端粒磨损的轨迹

• 批准号: 9332844
• 负责人: Ka Kahe
• 金额: $ 105.3万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9332844
• 关键词: Adult; Affect; African American; Aging; American; Ancillary Study; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Arsenic; Biological Markers; Blood; Cadmium; Caucasians; Cells; Chromosomes; Cognition; Cognitive; Data; Diet; Disease; Elements; Foundations; Funding; Future; General Population; Health; Heavy Metals; Heritability; Homeostasis; Human; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Learning; Length; Leukocytes; Link; Literature; Magnesium; Measurement; Measures; Mercury; Metal exposure; Micronutrients; Minerals; Nutritional; Participant; Persons; Physiological Processes; Play; Population; Prevention; Prevention strategy; Public Health; Race; Research; Risk; Role; Sampling; Selenium; Serum; Stroke; Trace Elements; United States National Institutes of Health; Urine; Visit; age effect; aged; base; cofactor; cognitive function; cohort; epidemiology study; follow-up; geographic difference; healthy aging; high risk; immune function; improved; interest; lifestyle factors; mortality; population based; pre-clinical; prevent; racial difference; remediation; repository; sex; study population; telomere

Studies indicate that a satisfactory content of some micronutrients within the cells maintains several immune functions, anti-inflammatory and anti-oxidant activities, which together may play a pivotal role in reducing the effects of aging. In contrast, although the underlying mechanisms are unclear, studies have linked some heavy metal exposure to cognitive decline, which is clearly associated with aging. Despite this, there remains a critical gap in the literature on how trace minerals, both nutritious elements and heavy metals, affect cognitive health. In particular, data directly relating trace mineral levels to cognitive decline are lacking. In addition, leukocyte telomere length (TL) has been consistently shown to have a direct relation with mortality and aging- related diseases in epidemiological studies, and is thus considered to be a biomarker of aging. TL has also been linked to cognitive function in different populations. Although TL is heritable, it can be modified by a host of environmental variables. Thus, identifying modifiable factors that may slow or prevent TL attrition would certainly have a major public health impact, as possible interventions are likely to be most effective during the early stages of preclinical disease. The overall objective of this project is to examine the longitudinal associations between trace mineral levels and cognitive decline and TL. Specifically, we will examine the trace mineral concentrations measured in urine or serum in relation to the trajectory of cognitive decline, as well as TL, and telomere attrition in a sub-cohort (n=2,391) of participants randomly selected from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, an ongoing US national population-based, general population cohort of 30,239 African American and Caucasian adults, aged 45 and older at baseline (2003-2007). The proposed study will help to identify at-risk Americans for cognitive decline and/or the consequences of aging. For nutritious minerals, information generated from this study will be useful for future interventions to maintain a homeostasis of micronutrients in relation to healthy aging; and for the toxic ones at low-to-moderate exposure level, knowledge gained will serve as a scientific foundation for remediation and prevention strategies to improve cognitive health or slow down the consequences of aging.

研究表明，细胞内某些微量营养素的含量令人满意，可以维持多种免疫功能 功能、抗炎和抗氧化活性，它们共同可能在减少 衰老的影响。相比之下，尽管根本机制尚不清楚，但研究已将一些重要的机制联系起来。 接触金属会导致认知能力下降，这显然与衰老有关。尽管如此，仍然存在 关于微量矿物质（营养元素和重金属）如何影响认知的文献中存在关键差距 健康。特别是，缺乏将微量矿物质水平与认知能力下降直接相关的数据。此外， 白细胞端粒长度（TL）已被一致证明与死亡率和衰老有直接关系 流行病学研究中的相关疾病，因此被认为是衰老的生物标志物。 TL也有 与不同人群的认知功能有关。虽然TL是可遗传的，但它可以被宿主修改 环境变量。因此，识别可能减缓或防止 TL 流失的可修改因素将 肯定会对公共卫生产生重大影响，因为可能的干预措施可能在 临床前疾病的早期阶段。该项目的总体目标是研究纵向 微量矿物质水平与认知能力下降和 TL 之间的关联。具体来说，我们将检查痕迹 尿液或血清中测量的矿物质浓度与认知能力下降的轨迹相关，以及 从原因中随机选择的参与者子队列 (n=2,391) 中的 TL 和端粒磨损 中风的地理和种族差异 (REGARDS) 研究是一项正在进行的基于美国全国人口的研究， 一般人群队列由 30,239 名基线年龄为 45 岁及以上的非裔美国人和白人成年人组成 （2003-2007）。拟议的研究将有助于识别有认知能力下降和/或认知能力下降风险的美国人 衰老的后果。对于营养矿物质，本研究产生的信息将对未来有用 维持与健康老龄化相关的微量营养素稳态的干预措施；对于有毒的 低到中度暴露水平，所获得的知识将作为补救和治疗的科学基础 改善认知健康或减缓衰老后果的预防策略。