A Low-Cost Wearable Connected Health Device for Monitoring Environmental Pollution Triggers of Asthma in Communities with Health Disparities

一种低成本可穿戴互联健康设备，用于监测健康差异社区中哮喘的环境污染诱因

• 批准号: 10601615
• 负责人: Krishna Naishadham
• 金额: $ 29.19万
• 依托单位: WI-SENSE, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601615
• 关键词: Address; Adult; Affect; African American; African American population; Age; Air; Air Pollutants; Air Pollution; American; Area; Asthma; Atmosphere; Bluetooth; Calibration; Cellular Phone; Chemicals; Chronic Obstructive Pulmonary Disease; Code; Collaborations; Color; Communities; Data; Detection; Devices; Diagnosis; Disease; Disparity population; Distant; Electronics; Elements; Environmental Exposure; Environmental Monitoring; Environmental Pollution; Ethnic Origin; Exhibits; Exposure to; Gases; Generations; Goals; Health; Health Care Costs; Healthcare Systems; Height; Heterogeneity; Housing; Humidity; Incidence; Industrialization; Institutional Racism; Intuition; Lab On A Chip; Laboratories; Measurement; Measures; Minority; Monitor; Morbidity - disease rate; Motor Vehicles; Nitrogen Dioxide; Outcome; Ozone; Participant; Particulate Matter; Patients; Persons; Phase; Physicians; Pilot Projects; Policies; Pollution; Population; Populations at Risk; Poverty; Public Health Schools; Race; Racial Segregation; Reaction Time; Reporting; Reproducibility; Research; Research Project Grants; Resistance; Respiratory Disease; Risk; Self Care; Self Management; Semiconductors; Signal Transduction; Site; Socioeconomic Status; Source; Spatial Distribution; Spirometry; Surface; Symptoms; Temperature; Testing; Time; Transportation; United States; Universities; Wrist; airway inflammation; asthma exacerbation; asthmatic patient; battery life; cohort; conditioning; connected health; cost; design; electronic sensor; empowerment; environmental monitoring device; fine particles; health disparity; improved; indexing; innovation; integrated circuit; metal oxide; metropolitan; microsensor; miniaturized sensor; mortality; patient home care; personal exposure monitor; pollutant; portability; power consumption; prototype; psychosocial stressors; pulmonary function; recruit; residential segregation; respiratory health; response; sensor; sensor technology; sex; signal processing; smartphone application; socioeconomics; volatile organic compound; wearable device; wearable sensor technology; wireless

Project Abstract Asthma affects 25 million Americans, and chronic obstructive pulmonary disease (COPD) affects 16 million, together costing 130 billion USD annually to the US healthcare system. Asthma is more prevalent in African American population (10.6%) than white population (7.7%). Poverty level has an impact as well, with twice as much asthma incidence in people below 100% of the poverty threshold as compared to people above 450% of the threshold. Racial-ethnic and socioeconomic health disparities in the US due to air pollution exposure are well documented and have persisted despite overall decreases in ozone and particulate matter pollution. This disproportionate exposure reflects generations of discriminatory practices including racially-segregated residential policies that result in communities of color being more frequently located near major sources of air pollution, both industrial and transportation-related. The proposed research project seeks to address health disparities related to air pollution by enabling self-monitoring of environmental triggers of asthma and other respiratory diseases, so that the patients are empowered for self-management of their disease. This study will develop and test a wearable sensor array with a small form-factor for monitoring personal exposure to several important air pollutants, and then pilot this device in a small panel of African-American adults with physiciandiagnosed asthma. The device will be sensitive to a variety of primary and secondary pollutants from both motorvehicle traffic and industrial emissions. It will employ metal oxide semiconductor sensors to measure ozone, nitrogen dioxide, and volatile organic compounds as well as relative humidity and ambient temperature. The device will be able to connect to Bluetooth-enabled smartphones for data logging and display purposes, yet it will be small enough to be worn on the wrist. We will validate the utility of this device for improving health by recruiting 20 African-American adults who live in the Atlanta area and have been diagnosed with asthma. These participants will use the device to monitor their air pollution exposure for one month. During this month, they will also measure their lung function twice per day using a small commercially-available spirometer that we will provide them. We will develop a smartphone application that will clearly display air quality data in an intuitive color-coded display. The app will also include lung function data from spirometry in a percent-predicted score relative to expected values based on age, height, sex and race. The overall goal of this project is to demonstrate the feasibility of a wearable device to assist in the identification of air pollution-related asthma triggers and to empower asthma patients to improve their health by reducing exposure.

项目摘要 哮喘影响 2500 万美国人，慢性阻塞性肺病 (COPD) 影响 1600 万美国人， 美国医疗保健系统每年总共花费 1300 亿美元。哮喘在非洲更为流行 美国人口（10.6%）高于白人人口（7.7%）。贫困水平也有影响，贫困程度是贫困水平的两倍 与贫困线 450% 以上的人群相比，贫困线 100% 以下的人群哮喘发病率更高 阈值。由于空气污染暴露，美国的种族民族和社会经济健康差异很大 尽管臭氧和颗粒物污染总体下降，但该现象仍然存在。这 不成比例的接触反映了几代人的歧视性做法，包括种族隔离 导致有色人种社区更频繁地位于主要空气源附近的住宅政策 与工业和交通相关的污染。拟议的研究项目旨在解决健康问题 通过自我监测哮喘和其他疾病的环境诱因，消除与空气污染相关的差异 呼吸系统疾病，使患者能够自我管理疾病。这项研究将 开发和测试具有小外形尺寸的可穿戴传感器阵列，用于监测个人接触多种物质的情况 重要的空气污染物，然后在一小群患有医生诊断为哮喘的非裔美国成年人中试用该设备。该装置将对机动车交通和工业排放中的各种一次和二次污染物敏感。它将采用金属氧化物半导体传感器来测量臭氧， 二氧化氮和挥发性有机化合物以及相对湿度和环境温度。这 设备将能够连接到支持蓝牙的智能手机以进行数据记录和显示，但它 尺寸足够小，可以戴在手腕上。我们将验证该设备在改善健康方面的效用 招募 20 名居住在亚特兰大地区并被诊断患有哮喘的非裔美国成年人。这些 参与者将使用该设备监测他们一个月的空气污染暴露情况。在这个月里，他们将 还使用我们将使用的小型商用肺活量计每天测量两次他们的肺功能 提供他们。我们将开发一款智能手机应用程序，以直观的方式清晰地显示空气质量数据 颜色编码显示。该应用程序还将包括来自肺活量测定的肺功能数据的百分比预测分数 相对于基于年龄、身高、性别和种族的预期值。该项目的总体目标是展示 可穿戴设备协助识别与空气污染相关的哮喘诱因的可行性 使哮喘患者能够通过减少接触来改善他们的健康。