Climate Change Effects on Pregnancy via a Traditional Food

气候变化通过传统食物对怀孕的影响

• 批准号: 10822202
• 负责人: Contessa Ricci
• 金额: $ 7.65万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-02 至 2027-01-01
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10822202
• 关键词: Accounting; Acute; Address; Adult; Affect; Behavioral; Chinook Salmon; Climate; Collaborations; Communities; Complex; Conceptions; Consumption; Core Facility; Custom; Data; Development; Diet; Dietary History; Educational workshop; Environment; Environmental Risk Factor; Exposure to; Fatty Acids; Food; Gestational Diabetes; Goals; Habits; Health; Hour; Human; Indigenous; Individual; Influentials; Isotopes; Knowledge; Laboratories; Link; Literature; Longevity; Machine Learning; Maternal Health; Mercury; Methods; Modeling; Mothers; Museums; Neighborhood Health Center; Nutritional; Outcome; Pacific Northwest; Participant; Persons; Play; Population; Pregnancy; Pregnancy Outcome; Prenatal Nutrition; Prenatal care; Prospective Studies; Questionnaires; Recurrence; Research; Research Training; Risk; Risk Factors; Role; Salmon; Scientist; Security; Series; Source; Specimen; Stratification; Surveys; System; Techniques; Technology; Temperature; Testing; Time; Training; Training Programs; Tribes; Underserved Population; Universities; Validation; Vulnerable Populations; Washington; Work; adverse pregnancy outcome; career networking; climate change; climate impact; cohort; experimental study; food consumption; food insecurity; food quality; food security; health disparity; improved; innovation; interdisciplinary approach; meetings; migration; modifiable risk; mother nutrition; nutrition; offspring; pregnant; resilience; skills; social health determinants; trait

PROJECT SUMMARY Impacts of climate change on traditional food systems is of great concern for Indigenous health and currently has unknown consequences for pregnancy. Maternal diet and nutrition are highly influential in pregnancy outcome and can affect the short- and long-term health of both mothers and offspring. Yet, while changing climate regimes have documented influences on food availability and quality, there is substantial underappreciation for the environments from which foods consumed during pregnancy are sourced. Certain adverse pregnancy outcomes (APOs) have been linked to maternal diet and nutrition, and Indigenous and First Nations groups have overall higher rates of APOs. Though maternal diet and nutrition have been identified as a potential target for improving health disparities, there is a paucity of literature concerning nutrition during pregnancy in Indigenous First Nations mothers. The research proposed will help fill this critical knowledge gap by identifying how climate-driven changes in the environment can influence the nutritional quality of a traditional food source, and how this may determine Indigenous maternal health outcomes. We approach investigating this in two Specific Aims using wild Pacific salmon consumption in pregnant First Nations peoples situated within the Pacific Northwest, USA because Pacific salmon are highly sensitive to environmental factors, and many Indigenous First Nations peoples within this region have been consuming Pacific salmon as a vital traditional food from time immemorial. In Specific Aim 1, we will establish effects of climate change on Pacific salmon nutritional content by: 1) investigating historical changes in nutritional metrics of museum specimen in relation to historical temperatures; and 2) experimental validation of nutritional changes through exposure of Pacific salmon to elevated temperatures. In Specific Aim 2, we will determine if Pacific salmon nutritional content contributes to pregnancy outcome by surveying Pacific salmon consumption in pregnant First Nations individuals, and using super learners (machine learning technology) to: 1) develop a model describing the relationship between Pacific salmon-specific nutritional contributions to maternal diet and pregnancy outcome; and 2) apply the model developed to manipulated data to test if changes in Pacific salmon-specific nutritional contributions to diet can influence pregnancy outcome. The research will be carried out with community health centers at Washington State University, and in close collaboration with regional Tribes and Nations. I will have access to state-of-the-art core facilities and laboratory spaces for this work and will be guided by experts in the skills and techniques that I will gain training in. To enrich my research training, I will be attending various workshops, seminar series, and scientific meetings to expand my professional network and prepare me as I transition to an independent scientist. Together, the research and training program developed will enhance the innovative potential of my future research and support my long-term goal of promoting climate resilience and addressing health disparities in vulnerable and underserved populations.

项目概要 气候变化对传统粮食系统的影响引起了原住民健康的高度关注，目前 对怀孕有未知的后果。母亲的饮食和营养对怀孕影响很大 结果并可能影响母亲和后代的短期和长期健康。然而，在改变的同时 气候制度对粮食供应和质量的影响已被记录在案， 对怀孕期间食用食物的来源环境认识不足。肯定 不良妊娠结局 (APO) 与母亲的饮食和营养以及土著和第一 国家集团的 APO 比例总体较高。尽管母亲的饮食和营养已被确定为 作为改善健康差距的潜在目标，有关营养问题的文献很少 原住民母亲怀孕。拟议的研究将有助于填补这一关键知识 通过确定气候驱动的环境变化如何影响营养质量来消除差距 传统食物来源的影响，以及这如何决定土著孕产妇健康结果。我们 使用怀孕期间食用野生太平洋鲑鱼的方法在两个具体目标中对此进行调查 位于美国太平洋西北部的民族，因为太平洋鲑鱼对 环境因素，以及该地区的许多原住民一直在消费 太平洋鲑鱼自古以来就是重要的传统食品。在具体目标 1 中，我们将确定以下效果： 气候变化对太平洋鲑鱼营养成分的影响：1）调查营养指标的历史变化 博物馆标本与历史气温的关系； 2）营养成分的实验验证 太平洋鲑鱼暴露在高温下会发生变化。在具体目标 2 中，我们将确定是否 通过调查太平洋鲑鱼的消费量，太平洋鲑鱼的营养成分有助于妊娠结局 在怀孕的原住民中，并使用超级学习者（机器学习技术）来：1）开发 描述太平洋鲑鱼特定营养对母亲饮食的贡献与 妊娠结局； 2）应用针对操纵数据开发的模型来测试太平洋是否发生变化 饮食中鲑鱼特有的营养成分会影响妊娠结局。研究将进行 与华盛顿州立大学的社区卫生中心合作，并与区域 部落和国家。我将能够使用最先进的核心设施和实验室空间来开展这项工作，并且 将由专家指导我将获得培训的技能和技术。为了丰富我的研究培训，我 将参加各种研讨会、研讨会系列和科学会议，以扩展我的专业知识 网络并为我过渡到独立科学家做好准备。研究和培训相结合 制定的计划将增强我未来研究的创新潜力并支持我的长期目标 促进气候适应能力并解决弱势和服务不足人群的健康差距。