Conflict of Interest in Clinical Practice Guideline Development

临床实践指南制定中的利益冲突

• 批准号: 7785880
• 负责人: SUSAN Lee NORRIS
• 金额: $ 30.03万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7785880
• 关键词: Conflict; Interest; Clinical; Practice; Guideline

DESCRIPTION (provided by applicant): The proposed research seeks to examine the relationship between financial conflicts of interest and recommendations in clinical practice guidelines. This application outlines an approach to describe the current level of industry relationships in an important segment of practice guidelines, specifically those on glycemic control in diabetes. We will examine the impact of industry relationships on the quality and specific recommendations in these practice guidelines. The specific aims are to: 1) assess the quality of the comparative effectiveness systematic reviews upon which practice guidelines for the pharmacotherapy of glycemic control in diabetes were based; 2) determine the quality and robustness of practice guidelines; 3) describe the financial relationships with industry among practice guideline sponsors and authors; and 4) examine relationships between industry, guideline authors and sponsors, and guideline recommendations. We will identify all relevant practice guidelines in the National Guidelines Clearinghouse,(tm) obtain the comparative effectiveness reviews upon which each practice guideline was based, and assess the quality of these reviews. The quality of each practice guideline will be assessed and we will independently generate recommendations using the underlying comparative effectiveness reviews for each guideline and an explicit framework. We will then compare the recommendations in the original practice guideline with our recommendations to assess the robustness of each recommendation. The frequency and type of financial relationships with industry for the authors and sponsor of each guideline will be identified, and we will examine the associations between those relationships and the quality and robustness of the practice guidelines. We will then examine the impact of financial relationships with industry on the percentage of pro-industry recommendations. Healthcare providers and patients must trust the information that they are provided with. Conflicts of interest can bias that information, which breaks that trust, decreases the credibility of the research or guidelines, and may ultimately lead to suboptimal patient care or even harm. Understanding the impact of industry relationships will help guideline sponsors to develop appropriate policies for managing conflict of interest.

描述（由申请人提供）：拟议的研究旨在检查利益冲突与临床实践指南中的建议之间的关系。该应用程序概述了一种在重要部分的实践指南中，特别是糖尿病血糖控制的方法中描述当前行业关系水平的方法。我们将研究这些实践指南中行业关系对质量和特定建议的影响。具体目的是：1）评估比较有效性的系统评价的质量，糖尿病中血糖控制药物的实践指南是基于哪些； 2）确定实践指南的质量和鲁棒性； 3）描述实践指南发起人和作者之间与行业的财务关系； 4）检查行业，指南作者和赞助商以及指南建议之间的关系。 我们将在国家准则交换所中确定所有相关实践指南，（TM）获得每个实践指南所基于的比较有效性审查，并评估这些评论的质量。将评估每个实践指南的质量，我们将使用每个指南和明确框架的基本比较有效性审查独立生成建议。然后，我们将将原始实践指南中的建议与我们的建议进行比较，以评估每个建议的鲁棒性。将确定与行业的财务关系的频率和类型，并确定每个准则的作者和赞助商，我们将研究这些关系之间的关联以及实践指南的质量和鲁棒性。然后，我们将研究与行业的财务关系对亲业建议百分比的影响。医疗保健提供者和患者必须信任提供的信息。利益冲突可能会偏向于破坏信任的信息，从而降低了研究或准则的信誉，并最终可能导致次优的患者护理甚至伤害。了解行业关系的影响将有助于指南发起人制定适当的政策来管理利益冲突。