Residential Radon Exposure and Stroke Risk: the REGARDS Study

住宅氡暴露和中风风险：REGARDS 研究

• 批准号: 10599123
• 负责人: Ka Kahe
• 金额: $ 61.26万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599123
• 关键词: Adult; African American; African American population; Air; American; Ancillary Study; Area; Arteries; Attention; Biological Markers; Blood; Blood Pressure; Blood Vessels; Brain; C-reactive protein; Carcinogens; Cardiovascular Diseases; Cardiovascular system; Caucasians; Cause of Death; Child; Classification; Country; County; Data; Diet; Disease; Environment; Environmental Risk Factor; Event; Exposure to; Factor VIII; Female; Fibrin fragment D; Gases; General Population; Geographic Factor; Geography; Goals; Health; Health care facility; Hemostatic Agents; Home; Hour; Household; Human; Hypertension; Individual; Infection; Inflammation; Inflammatory; Inhalation; International Agency for Research on Cancer; Ischemic Stroke; Life Style; Link; Lipids; Lung; Malignant neoplasm of lung; Measures; Metabolic Diseases; Minor; Modernization; Oxidative Stress Induction; Participant; Pathologic; Pattern; Penetration; Prevention; Publishing; Race; Radioactive; Radium; Radon; Random Allocation; Reactive Oxygen Species; Reasons for Geographic And Racial Differences in Stroke; Research; Research Personnel; Resistance; Risk; Risk Factors; Smoking; Stream; Stroke; Time; Tissues; Tobacco smoking behavior; United States Environmental Protection Agency; Variant; Veins; absorption; aged; burden of illness; cardiovascular disorder risk; cohort; design; disability; geographic difference; health care quality; insight; low socioeconomic status; male; modifiable risk; mortality; never smoker; particle; population based; randomized, clinical trials; stroke risk

Stroke remains a major cause of death and disability in the U.S. Identifying modifiable risk factors to develop effective prevention is the best strategy for reducing the burden of this disease. Racial and geographic variations in stroke mortality has been observed in the U.S. for decades. However, the reasons for these variations are still unclear. The impact of radon exposure in relation to human health has been increasingly recognized. Radon is a colorless, odorless, radioactive gas, formed through the radioactive decay of radium- 226, which enters homes, and other buildings, through cracks and penetrations in the building substructure. Radon has been classified as a human lung carcinogen by the International Agency for Research on Cancer since 1988. Recently, some studies conducted in countries outside the U.S. have linked radon, even at low levels of exposure, to the risk of stroke. In the U.S., county-level radon exposure has been associated with elevated mortality from cardiovascular and metabolic diseases. The overarching goal of this project is to examine the association between radon exposure and stroke risk and to investigate whether geographic variation of radon concentration is related to the distribution of stroke rate in the U.S. Specifically, we will examine radon exposure at both county- and household-level in relation to the risk of ischemic stroke. In addition, we will explore the underlying mechanisms by linking radon exposure to blood pressure, hypertension, lipid profile, and hemostatic and inflammatory biomarkers. Radon exposure is rising steadily within the modern North American residential environment. The proposed study will be the first to assess radon exposure and stroke risk in the U.S. general population, including both male and female African Americans and Caucasians. Since randomized clinical trial on radon exposure is not feasible, findings from this project will provide insights into the racial and geographic variations of stroke rate in the U.S. and possibly identify a potential modifiable risk factor for stroke.

中风仍然是美国死亡和残疾的主要原因 确定可改变的风险因素 有效预防是减轻该疾病负担的最佳策略。种族和地理 几十年来，美国一直观察到中风死亡率的变化。然而，造成这些现象的原因 变化仍不清楚。氡气暴露对人体健康的影响日益凸显 认可。氡气是一种无色、无味的放射性气体，由镭的放射性衰变形成。 226，它通过建筑物下部结构的裂缝和渗透进入住宅和其他建筑物。 氡气已被国际癌症研究机构列为人类肺癌致癌物 自 1988 年以来。最近，在美国以外的国家进行的一些研究已将氡气联系起来，即使在低浓度 暴露水平，增加中风的风险。在美国，县级氡气暴露与 心血管和代谢疾病的死亡率升高。该项目的总体目标是 检查氡暴露与中风风险之间的关联，并调查地理因素是否 氡气浓度的变化与美国的中风率分布有关。具体来说，我们将 检查县级和家庭一级的氡暴露与缺血性中风风险的关系。在 此外，我们将通过将氡暴露与血压联系起来来探索潜在的机制， 高血压、血脂、止血和炎症生物标志物。氡气暴露量稳步上升 现代北美居住环境。拟议的研究将是第一个评估氡气的研究 美国普通人群（包括男性和女性非裔美国人）的暴露和中风风险 白种人。由于氡暴露的随机临床试验不可行，该项目的结果将 深入了解美国中风发生率的种族和地理差异，并可能确定一个 中风的潜在可改变危险因素。