Serum fatty acids and ischemic stroke in women

女性血清脂肪酸与缺血性中风

• 批准号: 7470251
• 负责人: Ka Kahe
• 金额: $ 26.33万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470251
• 关键词: Acids; Animals; Arachidonic Acids; Arteries; Arteriosclerosis; Atherosclerosis; Biological; Biological Markers; Blood Pressure; Blood specimen; Clinical; Coronary heart disease; Data; Databases; Development; Dietary Fats; Eicosapentaenoic Acid; Epidemiologic Studies; Etiology; Fatty Acids; Fatty acid glycerol esters; Funding; Goals; Infarction; Intake; Ischemic Stroke; Knowledge; Life Style; Linoleic Acids; Linolenic Acids; Lipoproteins; Measurement; Myristic Acids; Nested Case-Control Study; Nutrient; Observational Study; Omega-3 Fatty Acids; Omega-6 Fatty Acids; Palmitic Acids; Pathogenesis; Patient Self-Report; Pattern; Play; Postmenopause; Public Health; Rate; Risk; Risk Factors; Role; Saturated Fatty Acids; Serum; Stroke; Testing; Trans Fatty Acids; Vascular Diseases; Woman; Women' s Health; blood lipid; case control; cerebral artery; disorder risk; elaidic acid; prospective; tool

DESCRIPTION (provided by applicant): While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Particularly, atherosclerosis may only be involved in large artery infarction, and other risk factors such as blood pressure may play more important role in stroke development However, data on the associations of fatty acids and ischemic stroke and its subtypes including lacunar (small artery), atherosclerotic (large artery) and cardioembolic infarction are lacking. The general goal of this study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women. A prospective nested case-control study of 971 ischemic stroke cases and 971 matched controls in the Women's Health Initiative (WHI) Observational Study is proposed to achieve the objectives. Two major endeavors are planned for the proposed project: 1) assess serum fatty acids composition with previously collected and stored blood specimens; and 2) perform the statistical analyses, which undertake the specific aims and hypothesis. The proposed study will fill the gap in knowledge regarding associations of fatty acids and subtypes of ischemic stroke. Findings from this project will potentially help identify people at high risk of ischemic stroke as well as clarify possible differences between fatty acids and risk of ischemic stroke versus risk of CHD. The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes. PUBLIC HEALTH RELEVANCE: The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes.

描述（由申请人提供）：虽然冠心病 (CHD) 和缺血性中风有一些共同的主要危险因素，但有关膳食脂肪和血管疾病风险的有限流行病学数据表明，脂肪酸与缺血性中风的关联与与 CHD 的关联不同。脂肪类型与冠心病之间已建立的关联似乎不适用于缺血性中风。对这一矛盾观察结果的一种解释性假设是，不同类型的脑动脉中的动脉硬化具有不同的因果模式。特别是，动脉粥样硬化可能只涉及大动脉梗塞，而血压等其他危险因素可能在中风发展中发挥更重要的作用。然而，有关脂肪酸与缺血性中风及其亚型（包括腔隙性中风（小动脉）、缺乏动脉粥样硬化（大动脉）和心源性梗塞。本研究的总体目标是检查绝经后妇女血清脂肪酸与缺血性中风及其亚型风险之间的关联。为了实现这些目标，建议对妇女健康倡议 (WHI) 观察研究中的 971 例缺血性中风病例和 971 例匹配对照进行前瞻性巢式病例对照研究。该项目计划进行两项主要工作：1）利用先前收集和储存的血液样本评估血清脂肪酸组成； 2) 进行统计分析，以实现特定的目标和假设。拟议的研究将填补有关脂肪酸与缺血性中风亚型关联的知识空白。该项目的研究结果可能有助于识别缺血性中风高风险人群，并阐明脂肪酸与缺血性中风风险与先天性心脏病风险之间可能存在的差异。拟议的研究旨在检查中风风险增加的绝经后女性中血清脂肪酸与缺血性中风及其亚型风险之间的关联。这是调查绝经后妇女中风风险的及时且经济的方法。这项研究产生的数据应该为缺血性中风的病因学提供新的信息，并为饮食原因的新探索提供数据。公共健康相关性：拟议的研究旨在检查中风风险增加的绝经后女性中血清脂肪酸与缺血性中风及其亚型风险之间的关联。这是调查绝经后妇女中风风险的及时且经济的方法。这项研究产生的数据应该为缺血性中风的病因学提供新的信息，并为饮食原因的新探索提供数据。