Developmental fMRI Study of Alcohol Use in Adolescence

青春期饮酒的发育功能磁共振成像研究

基本信息

批准号：
8741110
负责人：
DIANA H FISHBEIN
金额：
$ 15.05万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8741110
关键词：
13 year old Accounting Adolescence Adolescent Adult Adverse effects Affective Aggressive behavior Alcohol abuse Alcohol consumption Alcoholism Alcohols Amygdaloid structure Anterior Area Behavioral Belief Brain Characteristics Cognitive Data Collection Decision Making Deltastab Development Dose Drug abuse Drug usage Emotional Emotions Ensure Exhibits Exposure to Family Frequencies Functional Magnetic Resonance Imaging Grant Growth Heavy Drinking Illicit Drugs Impairment Insula of Reil Intervention Investigation Lead Longitudinal Studies Measures Mediator of activation protein Modeling Nature Neurocognitive Neurodevelopmental Deficit Neurons Neurotoxins Pathway interactions Pattern Pharmaceutical Preparations Prefrontal Cortex Process Prospective Studies Recording of previous events Regulation Research Risk Risk Factors Sampling Self-control as a personality trait Social Behavior Social support Socioeconomic Status Structure Synapses Tobacco Tobacco use Ventral Striatum Youth adolescents with alcohol use disorders alcohol effect alcohol expectancy alcohol misuse alcohol response alcohol use disorder alcohol use initiation binge drinking blood oxygen level dependent chronic alcohol ingestion cognitive function cohesion cohort drinking early alcohol use emerging adult falls inattention interest neurodevelopment parental monitoring peer influence programs prospective relating to nervous system response scaffold skills therapy design underage drinking white matter

项目摘要

DESCRIPTION (provided by applicant): Alcohol use is primarily initiated during vulnerable developmental years when white matter tracts arborize within the prefrontal cortex (PFC), and between the PFC, anterior cingulate, ventral striatum and limbic (affective) structures, and significant synaptic pruning occurs. This neuronal fine-tuning establishes the scaffolding for the progressive neurodevelopment of executive cognitive and emotional regulatory functions that are critical for emotional and behavioral self-control. The vulnerability of this process in adolescence may explain findings of impairments in adolescents with alcohol use problems and in adults with a history of chronic alcohol use that began in adolescence; early alcohol use and heavy episodic drinking in adolescence may lead to long-term neural and behavioral developmental consequences. Also unknown is whether some of the neurodevelopmental delays and deficits associated with alcohol use actually predate use, thereby increasing propensity to misuse alcohol. And as precursor conditions, they may be particularly susceptible to further damage in response to the continued use of alcohol. No study to date has attempted to track neurodevelopmental precursors and the changes in these processes resulting from varying levels of alcohol use throughout adolescence. The proposed 5-year prospective longitudinal fMRI study seeks to identify functional neuroanatomical substrates of neurodevelopmental liability to initiate and escalate alcohol use and chart the progressive nature of neurocognitive change as a consequence of varying levels of alcohol use during adolescence. This study will also, in effect, isolate the potential dose-dependent neurodevelopmental consequences of alcohol use from precursor conditions. Alcohol and drug-"na¿ve" 11- to 13-year-olds will be prescreened for characteristics predictive of alcohol problems to ensure that a sufficient number of youth (final n=154) will exhibit initiation and varying levels of escalation of drinking during the course of the study. Three 16 month waves of data collection will be conducted. Neurocognitive markers of developmental deficits and delays (e.g., inattention, risky decision making, emotional dysregulation) have been associated with alcohol, tobacco, and other drug use in previous research conducted by the study team and others, thus laying the groundwork for a longitudinal investigation of neurocognitive vulnerability factors in initiation and escalation of alcohol use and its potential effects (e.g., Brown & Tapert, 2004; Fishbein et al., 2005a,b; Giancola et al., 1996; Sher et al., 1997; Tarter et al., 2004; Zeigler et al., 2005). In all analyses, adjustments will be made for concurrent use of tobacco and other drugs, SES, IQ, parental alcohol and drug abuse, and other relevant covariates, such as aggression, alcohol expectancies, normative beliefs about alcohol, social supports, and deviance. Overall, the proposed study has implications for understanding underlying mechanisms in the development of maladaptive social behaviors that increase risk for alcohol initiation and escalation and suggest specific strategies for interventions that strengthen these functions, thereby altering the developmental trajectory for at-risk adolescents.

描述（由申请人提供）：在脆弱的发育年份中，饮酒是原始的，在前额叶皮层（PFC）内的白质区域，Anderior cingularate，腹侧纹状体和边缘（情感）结构（情感）结构，以及重要的PTIC PTIC PTIC培养这种神经元的微调建立了渐进式的渐进性。对情感自我控制至关重要的行政人员的神经发育可能会在青少年中解释有酒精使用问题的青少年的脆弱性ssocits的缺陷与酒精相关联，因此，涉及滥用酒精的倾向，响应于继续使用酒精。神经发育的神经解剖学底物和饮酒和图表的升级。条件。 Ve“ 11至13岁的人将被预先筛选出来的酒精问题，以确保在研究过程中表现出令人难以置信的麻木n = 154），并表现出饮酒的升级水平。三个16个16个月的发育浪潮赤字和延误（例如，风险，冒险，有风险的造成，情绪失调）与研究团队和其他人进行的可行性研究中的酒精，烟草和其他药物使用有关，因此是对神经认知脆弱性的纵向研究的基础启动和升级的因素。 Zeigler等人。具体增强这些功能。