Optimizing a mindful intervention for urban minority youth via stress physiology

通过压力生理学优化对城市少数民族青年的正念干预

基本信息

批准号：
10475371
负责人：
DIANA H FISHBEIN
金额：
$ 50.47万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-17 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475371
关键词：
Adolescence Adolescent Adult Affect Affective Affective Symptoms Arousal Baltimore Behavior Behavioral Biofeedback Brain Characteristics Cities Clinical Data Development Disadvantaged Disease Economics Emotional Exhibits Foundations Future Galvanic Skin Response Goals High School Student Household Intervention Investigation Knowledge Laboratories Life Low income Measurable Measures Mediating Mediation Mediator of activation protein Meditation Mind-Body Intervention Modeling Mood Disorders Neighborhoods Neuronal Plasticity Nonprofit Organizations Outcome Participant Pathway interactions Pattern Personal Satisfaction Phase Physiological Physiology Population Population Group Poverty Pre-Post Tests Process Psychophysiology Randomized Randomized Controlled Trials Recording of previous events Recovery Reporting Research Risk Role Sampling Schools Services Stress Students Subgroup Syndrome System Target Populations Trauma Traumatic Stress Disorders Work Youth acceptability and feasibility active control acute stress age group attentional control base biological adaptation to stress body system clinically relevant coping cost demographics design emotion regulation experience externalizing behavior follow-up functional outcomes heart rate variability high school improved inner city innovation insight interest intervention effect maltreatment mindfulness mindfulness intervention neuroimaging neurophysiology novel poor communities post intervention preservation programs recruit response sex stress management stress reactivity stress symptom teacher trauma exposure trauma symptom traumatic stress urban minority vulnerable adolescent

项目摘要

PROJECT SUMMARY The proposed R61/R33 phased study aims to elucidate the physiological stress mechanisms underlying effects of a mindfulness program designed to target youth at risk for externalizing, affective and traumatic stress disorders by virtue of significant environmental disadvantage. Adolescents for each phase will be recruited from schools serving high poverty neighborhoods in Baltimore City where adversity and experiences of trauma and maltreatment are common. The intervention is currently being implemented in a few Baltimore City schools and other settings by the Holistic Life Foundation, Inc. (HLF), a non-profit organization with a lengthy track record of providing mindfulness-based programming (breath work and meditation) to impoverished youth. Both empirical and anecdotal reports of significant change in emotion regulation have been reported with this intervention, yet similar to most mindfulness programs, mechanisms of effects have not yet been delineated, particularly in disadvantaged youth. Our primary mechanism of interest is stress physiology, as measured by heart rate variability (HRV) and skin conductance response (SCR) during acute stress, a central component of emotion regulation and implicated in relevant clinical syndromes (e.g., externalizing behaviors, affective disorders).To identify the characteristics of youth that predict intervention response (moderation) and the stress-related pathways through which positive outcomes are achieved (mediation), we propose to conduct two RCTs with the ultimate goal to maximally improve externalizing behaviors and affective and traumatic disorders in at-risk youth. In the R61, we will intensively measure mechanistic effects of the mindfulness program to establish its effects in a conceptually appropriate population. Students in 4 Baltimore City High Schools will be randomized to treatment and active control conditions (N=160 students) and assessed at baseline, post-intervention and follow-up. Stress physiological profiles that improve in response to intervention will be identified. In the R33, we will conduct a larger RCT (8 schools, N=240) with assignment either to the mindfulness program or the mindfulness program plus an enhancement—HRV biofeedback—shown to independently exert effects on stress responses. Comparisons will be made between conditions and then a mediation model will be applied to the intervention condition exhibiting maximal effects to determine whether positive change in stress physiology explains improvements in outcomes. This sequence of studies will characterize participants who are maximally impacted by mindfulness and will differentiate between treatment conditions, leading to more efficient and effective targeting and scaling. In so doing, this research will break new ground in the rapidly growing field of youth mindfulness-based interventions by identifying key physiological mechanisms of effect for common mindfulness practices.

项目概要拟议的 R61/R33 阶段性研究旨在阐明潜在的生理应激机制旨在针对面临外化、情感和创伤风险的青少年的正念计划的效果每个阶段的青少年都会因显着的环境劣势而出现应激障碍。从为巴尔的摩市的高贫困社区服务的学校招募，那里有逆境和经历目前，巴尔的摩的一些地区正在实施这种干预措施。城市学校和其他机构由 Holistic Life Foundation, Inc. (HLF) 提供，这是一个非盈利组织，提供基于正念的编程（呼吸工作和冥想）的长期记录实证和轶事报告都表明，贫困青年的情绪调节发生了显着变化。已经有这种干预措施的报道，但与大多数正念项目类似，效果机制还没有尚未明确，特别是在弱势青年中。我们感兴趣的主要机制是压力生理学，通过心率变异性 (HRV) 和急性应激期间的皮肤电导反应（SCR），是情绪调节和与相关临床综合征（例如外化行为、情感障碍）有关。识别预测干预反应（适度）和压力相关途径的青少年特征通过这取得了积极的成果（调解），我们建议进行两项随机对照试验，最终结果是目标是最大限度地改善高危青少年的外化行为以及情感和创伤性障碍。 R61，我们将集中测量正念计划的机械效应，以确定其在概念上适当的人群。 4 所巴尔的摩市高中的学生将被随机分配接受治疗。和主动控制条件（N = 160 名学生），并在基线、干预后和随访时进行评估。在 R33 中，我们将确定因干预而改善的应激生理特征。进行更大规模的 RCT（8 所学校，N=240），分配给正念项目或正念计划加上增强功能——HRV生物反馈——被证明可以独立地对将在条件之间进行比较，然后应用中介模型。表现出最大效果的干预条件，以确定应激生理学是否发生积极变化这一系列研究将描述谁的效果最大。受到正念的影响，并将区分治疗条件，从而提高效率和通过这样做，这项研究将在快速发展的领域开辟新天地。通过确定影响常见问题的关键生理机制，开展基于青少年正念的干预措施正念练习。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Implementing Adolescent Wellbeing and Health Programs in Schools: Insights from a Mixed Methods and Multiple Informant Study.

DOI：
10.1007/s11121-022-01481-2
发表时间：
2023-05
期刊：
PREVENTION SCIENCE
影响因子：
3.5
作者：
Dariotis, Jacinda K;Mabisi, Keren;Jackson-Gordon, Rachel;Yang, Nan;Rose, Emma Jane;Mendelson, Tamar;Fishbein, Diana H
通讯作者：
Fishbein, Diana H